Protein: HCH1
Hsp90 co-chaperone HCH1 (High-copy Hsp90 suppressor protein 1)

Gene: HCH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 57
UniProt ID: P53834

Gene Ontology (top 5):
GO:0001671 - ATPase activator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

393125

HSP82
ATP-dependent molecular chaperone HSP82

7

11

Small-scale

0.952

High

579836

HSC82
ATP-dependent molecular chaperone HSC82

6

11

Small-scale

0.934

High

923777

AHA1
Hsp90 co-chaperone AHA1

3

1

Small-scale

0.814

High

850128

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

806330

KOG1
Target of rapamycin complex 1 subunit KOG1

1

1

High-throughput

0.552

High

527334

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.552

High

545786

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.552

High

742107

HSP7F
Heat shock protein homolog SSE1

2

7

High-throughput

0.552

High

776627

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.518

High

791977

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.518

High

449159

CALM
Calmodulin

1

0

High-throughput

0.513

High

923087

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

923771

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

790366

STT4
Phosphatidylinositol 4-kinase STT4

1

0

High-throughput

0.493

High

818692

GPP2
Glycerol-1-phosphate phosphohydrolase 2

1

0

High-throughput

0.493

High

923774

RUB1
NEDD8-like protein RUB1

1

0

High-throughput

0.493

High

923773

ULP1
Ubiquitin-like-specific protease 1

1

2

High-throughput

0.481

High

923776

RIO1
Serine/threonine-protein kinase RIO1

1

1

Small-scale

0.481

High

383825

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.479

High

435262

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

455189

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

503167

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

512571

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

674755

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

707808

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

747503

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

802304

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

874450

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

923772

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

923775

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

741042

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

825707

SPO22
Sporulation-specific protein 22

1

0

Small-scale

0.458

High

365139

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.445

High

367087

ATPB
ATP synthase subunit beta, mitochondrial

1

4

High-throughput

0.445

High

394783

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

486273

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.445

High

524741

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.445

High

592411

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.445

High

597232

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.445

High

598896

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

2

High-throughput

0.445

High

734166

EF2
Elongation factor 2

1

2

High-throughput

0.445

High

740199

RPN2
26S proteasome regulatory subunit RPN2

1

4

High-throughput

0.445

High

752575

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

802671

YHI0
Putative proline--tRNA ligase YHR020W

1

2

High-throughput

0.445

High

803637

RPN1
26S proteasome regulatory subunit RPN1

1

4

High-throughput

0.445

High

816341

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.445

High

819413

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

836823

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.445

High

358300

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

439391

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.426

High

779087

EF1G2
Elongation factor 1-gamma 2

1

0

High-throughput

0.426

High

796168

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.426

High

575489

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

2

High-throughput

0.407

High

597526

EF3A
Elongation factor 3A

1

4

High-throughput

0.407

High

603523

VATA
V-type proton ATPase catalytic subunit A

1

6

High-throughput

0.407

High

836072

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.407

High

849538

GCN20
Protein GCN20

1

3

High-throughput

0.407

High


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Last updated: 11Aug2025