Protein: HSP90
Heat shock protein 90 (Abnormal dauer formation protein 21)

Gene: HSP90, hsp-90
Organism: Caenorhabditis elegans
Interactions: 48
UniProt ID: Q18688

Gene Ontology (top 5):
GO:0002119 - nematode larval development
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

145623

CDC37
Probable Hsp90 co-chaperone cdc37

6

13

Small-scale

0.941

High

195281

STIP1
Stress-induced-phosphoprotein 1

3

20

Small-scale

0.875

High

1166194

HSP90
Heat shock protein 90

3

17

Small-scale

0.861

High

634984

DAF1
Cell surface receptor daf-1

1

17

Small-scale

0.740

High

482115

HSP1
Heat shock protein hsp-1

1

12

Small-scale

0.724

High

1043383

SPK1
Serine/threonine-protein kinase spk-1

1

20

High-throughput

0.698

High

113696

G5EG62
UNC-45

3

20

Small-scale

0.689

High

895876

DAF4
Cell surface receptor daf-4

1

17

Small-scale

0.656

High

94757

E0R7L7
Serine/threonine specific protein phosphatases domain-containing protein

1

9

Small-scale

0.647

High

233841

O45418
peptidylprolyl isomerase

1

20

Small-scale

0.647

High

113946

G5EGG2
Homolog of S. Pombe Rad

3

13

High-throughput

0.635

High

1166201

Q21829
ATP-dependent DNA helicase II subunit 2

3

4

High-throughput

0.635

High

196616

NHR51
Nuclear hormone receptor family member nhr-51

1

20

High-throughput

0.625

High

1165099

PK1
Serine/threonine-protein kinase pak-1

1

20

Small-scale

0.621

High

1166206

Q93168
Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein

1

11

Small-scale

0.618

High

386950

MYO4
Myosin-4

2

4

Small-scale

0.611

High

1166196

Q18949
SGS domain-containing protein

1

9

Small-scale

0.579

High

1084001

LE756
Protein let-756

1

2

Small-scale

0.573

High

304306

PPN1
Papilin

1

3

High-throughput

0.541

High

853054

SMA4
Dwarfin sma-4

1

1

High-throughput

0.541

High

1018819

U2AF2
Splicing factor U2AF 65 kDa subunit

1

6

High-throughput

0.541

High

1166205

KARG2
Probable arginine kinase ZC434.8

1

2

High-throughput

0.541

High

912479

PFD6
Probable prefoldin subunit 6

1

0

Small-scale

0.529

High

1166199

Q20308
Nicotinamide N-methyltransferase

1

0

High-throughput

0.518

High

1166211

TYDP2
5'-tyrosyl-DNA phosphodiesterase

1

0

High-throughput

0.518

High

1166210

NHR67
Nuclear hormone receptor family member nhr-67

1

14

High-throughput

0.494

High

195999

O17218
Ribosomal Protein, Small subunit

1

2

High-throughput

0.494

High

72222

A8WIR1
Ribosomal Protein, Small subunit

1

2

High-throughput

0.481

High

113275

G5EFG1
PDZ and LIM domain protein Zasp

1

2

High-throughput

0.481

High

109958

G5EBS4
DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein

1

1

High-throughput

0.479

High

110977

G5ECM4
GTL-1

1

1

High-throughput

0.479

High

759950

GLH1
ATP-dependent RNA helicase glh-1

1

3

High-throughput

0.479

High

1036319

SMA2
Dwarfin sma-2

1

1

High-throughput

0.479

High

1166195

BTF3
Transcription factor BTF3 homolog

1

4

Small-scale

0.479

High

1166200

SYMC
Methionine--tRNA ligase, cytoplasmic

1

10

Small-scale

0.479

High

1166209

Q9TXM1
Uncharacterized protein

1

1

High-throughput

0.479

High

1166202

Q21875
SWIM-type domain-containing protein

1

0

Small-scale

0.460

High

1166203

RBGPR
Rab3 GTPase-activating protein regulatory subunit

1

0

High-throughput

0.458

High

113403

G5EFL5
PDZ and LIM domain protein Zasp

1

2

High-throughput

0.457

High

1166207

Q9GRZ9
Ribosome-binding protein 1

1

10

Small-scale

0.439

High

232666

O44490
ELKS/RAB6-interacting/CAST family member 2

1

8

High-throughput

0.437

High

759341

ZFP1
Zinc finger protein zfp-1

1

4

Small-scale

0.437

High

1018580

LIN53
Probable histone-binding protein lin-53

1

11

High-throughput

0.437

High

1166197

WDR46
WD repeat-containing protein 46

1

11

High-throughput

0.437

High

1166198

Q20234
PDZ domain-containing protein

1

0

High-throughput

0.282

High

1166204

FZO1
Transmembrane GTPase fzo-1

1

0

Small-scale

0.251

Low

1166208

RDE10
RNA interference defective protein 10

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025