HitPredict

Interactor 1: ML12A (P19105)
Myosin regulatory light chain 12A (Epididymis secretory protein Li 24) (HEL-S-24) (MLC-2B) (Myosin RLC) (Myosin regulatory light chain 2, nonsarcomeric) (Myosin regulatory light chain MRLC3)
Gene: MYL12A

Interactor 2: MYH11 (P35749)
Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)
Gene: MYH11

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head, EF-hand_7~Myosin_N
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 171 Hs			1 1972
+	Ce
		104561 CALM_CAEEL (16-92): 2.97e-09: 54.5: 27.16		G5EBY3_CAEEL (1-1945): 0: 1308: 45.00
+	Hs
		159551 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYH11_HUMAN (1-1972): 0: 1106: 100.00
+	Hs
		580614 ML12A_HUMAN (1-171): 2.06e-65: 199: 100.00		MYH9_HUMAN (885-1972): 1.2e-64: 246: 17.87
+	Hs
		159549 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYH9_HUMAN (885-1972): 1.2e-64: 246: 17.87
+	Hs
		580615 ML12A_HUMAN (1-171): 2.06e-65: 199: 100.00		MYH10_HUMAN (885-1971): 1.62e-63: 243: 19.36
+	Hs
		624341 MYL9_HUMAN (14-171): 2.29e-64: 196: 94.30		MYH9_HUMAN (885-1972): 1.2e-64: 246: 17.87
+	Hs
		159550 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYH10_HUMAN (885-1971): 1.62e-63: 243: 19.36
+	Hs
		624342 MYL9_HUMAN (14-171): 2.29e-64: 196: 94.30		MYH10_HUMAN (885-1971): 1.62e-63: 243: 19.36
+	Mm
		1143166 Q6ZWQ9_MOUSE (1-171): 4.56e-64: 196: 97.09		MYH10_MOUSE (912-1972): 5.77e-60: 231: 14.26
+	Hs
		580665 ML12A_HUMAN (1-171): 2.06e-65: 199: 100.00		MYH14_HUMAN (885-1970): 1.8e-56: 219: 17.79
+	Hs
		159595 ML12B_HUMAN (13-171): 4.64e-65: 198: 99.37		MYH14_HUMAN (885-1970): 1.8e-56: 219: 17.79
+	Hs
		501101 MLRV_HUMAN (9-165): 2.99e-55: 173: 58.23		MYH1_HUMAN (1220-1972): 3.04e-47: 189: 13.80
+	Dm
		404219 MLR_DROME (8-162): 4.11e-30: 110: 41.14		MYSA_DROME (728-1810): 1.68e-59: 229: 16.47
+	Dm
		773034 SQH_DROME (1-171): 2.38e-60: 186: 80.46		MYSN_DROME (1442-1972): 4.67e-34: 146: 18.25
+	Hs
		648467 CALL3_HUMAN (31-92): 1.25e-10: 58.2: 27.27		MYH9_HUMAN (885-1972): 1.2e-64: 246: 17.87
+	Ce
		361111 MLR1_CAEEL (23-169): 2.25e-39: 133: 49.32		MYO4_CAEEL (736-1445): 3.56e-29: 130: 13.59
+	Ce
		361112 MLR2_CAEEL (23-169): 1.93e-39: 133: 49.32		MYO4_CAEEL (736-1445): 3.56e-29: 130: 13.59
+	Ce
		361122 MLR1_CAEEL (23-169): 2.25e-39: 133: 49.32		MYO1_CAEEL (732-1424): 6.54e-28: 125: 14.23
+	Ce
		361123 MLR2_CAEEL (23-169): 1.93e-39: 133: 49.32		MYO1_CAEEL (732-1424): 6.54e-28: 125: 14.23