Protein: PFKA2
ATP-dependent 6-phosphofructokinase subunit beta (EC 2.7.1.11) (ATP-dependent 6-phosphofructokinase) (ATP-PFK) (Phosphofructokinase 2) (Phosphohexokinase)

Gene: PFKA2, PFK2
Organism: Saccharomyces cerevisiae S288C
Interactions: 198
UniProt ID: P16862

Gene Ontology (top 5):
GO:0003729 - mRNA binding
GO:0003872 - 6-phosphofructokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

598802

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

11

14

Small-scale

0.976

High

394200

EF1A
Elongation factor 1-alpha

2

1

High-throughput

0.618

High

531234

METK1
S-adenosylmethionine synthase 1

2

1

High-throughput

0.618

High

364311

CDK1
Cyclin-dependent kinase 1

2

3

High-throughput

0.594

High

598962

SIS1
Protein SIS1

3

2

High-throughput

0.593

High

598944

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

14

High-throughput

0.590

High

599042

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

599065

GCN5
Histone acetyltransferase GCN5

2

2

High-throughput

0.574

High

543720

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.571

High

502827

RS22A
Small ribosomal subunit protein uS8A

2

1

High-throughput

0.558

High

599087

RS10A
Small ribosomal subunit protein eS10A

2

1

High-throughput

0.558

High

518190

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.536

High

598948

FKBP
FK506-binding protein 1

1

1

High-throughput

0.536

High

598949

PP11
Serine/threonine-protein phosphatase PP1-1

1

4

High-throughput

0.536

High

598956

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

2

High-throughput

0.536

High

598964

KIN82
Serine/threonine-protein kinase KIN82

1

4

High-throughput

0.536

High

598989

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.536

High

598992

SPT7
SAGA complex subunit SPT7

1

3

High-throughput

0.536

High

599026

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.536

High

599056

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

599061

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

599055

COPA
Coatomer subunit alpha

2

3

High-throughput

0.533

High

599046

LSM8
LSM2-LSM8 complex subunit LSM8

1

1

High-throughput

0.508

High

441022

KAPA
cAMP-dependent protein kinase type 1

1

5

High-throughput

0.501

High

448632

SNF1
Carbon catabolite-derepressing protein kinase

1

2

High-throughput

0.501

High

598945

PHO85
Cyclin-dependent protein kinase PHO85

1

3

High-throughput

0.501

High

598951

MCK1
Protein kinase MCK1

1

3

High-throughput

0.501

High

598969

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.501

High

598985

SWE1
Mitosis inhibitor protein kinase SWE1

1

8

High-throughput

0.501

High

599008

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

8

High-throughput

0.501

High

599011

KSP1
Serine/threonine-protein kinase KSP1

1

7

High-throughput

0.501

High

599027

RSP5
E3 ubiquitin-protein ligase RSP5

1

3

High-throughput

0.501

High

599083

PSK2
Serine/threonine-protein kinase PSK2

1

6

High-throughput

0.501

High

599091

RTK1
Probable serine/threonine-protein kinase RTK1

1

8

High-throughput

0.501

High

366914

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.500

High

437871

KAPC
cAMP-dependent protein kinase type 3

1

5

High-throughput

0.500

High

440895

CDC7
Cell division control protein 7

1

6

High-throughput

0.500

High

453406

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.500

High

560645

KIN2
Serine/threonine-protein kinase KIN2

1

4

High-throughput

0.500

High

574625

KSS1
Mitogen-activated protein kinase KSS1

1

12

High-throughput

0.500

High

584333

GCN2
eIF-2-alpha kinase GCN2

1

2

High-throughput

0.500

High

598947

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.500

High

598953

DBF2
Cell cycle protein kinase DBF2

1

9

High-throughput

0.500

High

598957

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

5

High-throughput

0.500

High

598958

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

5

High-throughput

0.500

High

598959

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

4

High-throughput

0.500

High

598960

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

1

High-throughput

0.500

High

598963

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.500

High

598965

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.500

High

598970

CDC15
Cell division control protein 15

1

3

High-throughput

0.500

High

598972

HRR25
Casein kinase I homolog HRR25

1

3

High-throughput

0.500

High

598976

PSK1
Serine/threonine-protein kinase PSK1

1

4

High-throughput

0.500

High

598978

DBF20
Serine/threonine-protein kinase DBF20

1

8

High-throughput

0.500

High

598979

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

4

High-throughput

0.500

High

598980

ARP2
Actin-related protein 2

1

2

High-throughput

0.500

High

598988

PRS6B
26S proteasome regulatory subunit 6B homolog

1

3

High-throughput

0.500

High

598993

MDJ1
DnaJ homolog 1, mitochondrial

1

2

High-throughput

0.500

High

598997

DHR2
Probable ATP-dependent RNA helicase DHR2

1

1

High-throughput

0.500

High

599000

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.500

High

599009

RCK1
Serine/threonine-protein kinase RCK1

1

5

High-throughput

0.500

High

599010

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.500

High

599013

DBP8
ATP-dependent RNA helicase DBP8

1

3

High-throughput

0.500

High

599032

RFC4
Replication factor C subunit 4

1

1

High-throughput

0.500

High

599060

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

12

High-throughput

0.500

High

599062

PRS8
26S proteasome regulatory subunit 8 homolog

1

3

High-throughput

0.500

High

599073

SML1
Ribonucleotide reductase inhibitor protein SML1

1

1

High-throughput

0.500

High

599084

RBX1
RING-box protein HRT1

1

2

High-throughput

0.500

High

599037

EGH1
Ergosteryl-beta-glucosidase

1

0

High-throughput

0.493

High

598946

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.489

High

517879

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

599043

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.480

High

599025

RBG1
Ribosome-interacting GTPase 1

1

0

High-throughput

0.479

High

599033

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.479

High

599045

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.479

High

599053

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.479

High

599066

CCE1
Cruciform cutting endonuclease 1, mitochondrial

1

0

High-throughput

0.479

High

599071

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.479

High

599078

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.479

High

599093

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.479

High

149562

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

364910

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.479

High

368402

TPIS
Triosephosphate isomerase

1

1

High-throughput

0.479

High

368581

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.479

High

392178

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

401869

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

441682

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

578784

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

598952

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

598955

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

High-throughput

0.479

High

598966

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

598968

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

598973

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

598975

MCM4
DNA replication licensing factor MCM4

1

6

High-throughput

0.479

High

598977

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

598982

HOG1
Mitogen-activated protein kinase HOG1

1

10

High-throughput

0.479

High

598984

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

598987

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.479

High

598996

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

598999

MCM7
DNA replication licensing factor MCM7

1

3

High-throughput

0.479

High

599002

ATG8
Autophagy-related protein 8

1

3

High-throughput

0.479

High

599005

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.479

High

599012

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

599015

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

599022

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

599039

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.479

High

599047

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

599048

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.479

High

599051

MCM6
DNA replication licensing factor MCM6

1

5

High-throughput

0.479

High

599052

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

599058

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

599064

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

599068

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

599080

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

2

Small-scale

0.479

High

599085

SGO1
Shugoshin

1

1

High-throughput

0.479

High

599086

MCA1
Metacaspase-1

1

2

High-throughput

0.479

High

599089

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

599098

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.479

High

599099

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.479

High

599101

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

477508

MYO1
Myosin-1

1

0

Small-scale

0.458

High

598994

ATG19
Autophagy-related protein 19

1

0

Small-scale

0.458

High

599035

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

599059

RAGAB
GTP-binding protein GTR1

1

0

Small-scale

0.458

High

599069

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

599070

GIS4
Protein GIS4

1

0

High-throughput

0.458

High

598986

PRP40
Pre-mRNA-processing protein PRP40

1

1

High-throughput

0.457

High

405016

LEU3
3-isopropylmalate dehydrogenase

1

1

High-throughput

0.457

High

459006

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.457

High

599017

UTP9
U3 small nucleolar RNA-associated protein 9

1

1

High-throughput

0.457

High

599020

TEM1
Protein TEM1

1

1

High-throughput

0.457

High

599028

UTP7
U3 small nucleolar RNA-associated protein 7

1

3

High-throughput

0.457

High

599040

PFS2
Polyadenylation factor subunit 2

1

5

High-throughput

0.457

High

510158

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

522965

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

525843

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

598954

NPR1
Nitrogen permease reactivator protein

1

15

High-throughput

0.445

High

598981

APE2
Aminopeptidase 2, mitochondrial

1

2

High-throughput

0.445

High

598990

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

599001

SEA4
SEH-associated protein 4

1

1

High-throughput

0.445

High

599006

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

3

High-throughput

0.445

High

599007

YM8C
Uncharacterized deoxyribonuclease YMR262W

1

1

High-throughput

0.445

High

599030

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

599036

DJP1
DnaJ-like protein 1

1

1

High-throughput

0.445

High

599095

SMT3
Ubiquitin-like protein SMT3

1

4

High-throughput

0.439

High

409913

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

433422

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

512793

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

598971

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

598983

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

598991

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

599004

GID4
GID complex substrate-recognition subunit 4

1

1

High-throughput

0.437

High

599018

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

599024

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

599038

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

599044

NU192
Nucleoporin NUP192

1

1

High-throughput

0.437

High

599072

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

599079

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

599088

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

599092

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

454072

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.426

High

531440

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.426

High

598950

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.426

High

599016

YHI9
Uncharacterized isomerase YHI9

1

0

High-throughput

0.426

High

599021

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.426

High

599023

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.426

High

599050

NIF3
NGG1-interacting factor 3

1

0

High-throughput

0.426

High

599057

FMP41
Oxaloacetate tautomerase FMP41, mitochondrial

1

0

High-throughput

0.426

High

599075

NSE3
Non-structural maintenance of chromosome element 3

1

0

High-throughput

0.426

High

599076

YL287
Uncharacterized protein YLR287C

1

0

High-throughput

0.426

High

598961

ROX1
Repressor ROX1

1

3

High-throughput

0.407

High

598998

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

3

High-throughput

0.407

High

599034

JEM1
DnaJ-like chaperone JEM1

1

4

High-throughput

0.407

High

599049

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.407

High

599067

WDR59
Maintenance of telomere capping protein 5

1

8

High-throughput

0.407

High

599094

CENPH
Inner kinetochore subunit MCM16

1

1

High-throughput

0.407

High

561410

TBP
TATA-box-binding protein

2

0

High-throughput

0.307

High

599019

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.279

Low

599082

PSR2
Probable phosphatase PSR2

1

0

High-throughput

0.279

Low

599031

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

449389

SPT2
Protein SPT2

1

0

High-throughput

0.261

Low

550618

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.261

Low

598967

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

599081

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.261

Low

599097

SWM1
Anaphase-promoting complex subunit SWM1

1

0

High-throughput

0.261

Low

598974

SEC65
Signal recognition particle subunit SEC65

1

0

High-throughput

0.249

Low

598995

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

599003

STU1
Protein STU1

1

0

Small-scale

0.249

Low

599014

MUP3
Low-affinity methionine permease

1

0

High-throughput

0.249

Low

599029

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.249

Low

599041

SET4
SET domain-containing protein 4

1

0

Small-scale

0.249

Low

599054

COPZ
Coatomer subunit zeta

1

0

High-throughput

0.249

Low

599077

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

599096

PST1
Cell wall mannoprotein PST1

1

0

High-throughput

0.249

Low

599063

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.232

Low

599074

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low

599090

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.232

Low

599100

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025