Protein: PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha (EC 2.7.1.11) (ATP-dependent 6-phosphofructokinase) (ATP-PFK) (Phosphofructokinase 1) (Phosphohexokinase)

Gene: PFKA1, PFK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 187
UniProt ID: P16861

Gene Ontology (top 5):
GO:0003872 - 6-phosphofructokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

598802

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

11

14

Small-scale

0.976

High

598801

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

3

14

Small-scale

0.828

High

598894

TBG
Tubulin gamma chain

2

3

High-throughput

0.621

High

543719

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.611

High

471371

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

2

0

High-throughput

0.602

High

522964

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.601

High

486011

TBA1
Tubulin alpha-1 chain

2

3

Small-scale

0.594

High

598932

LKHA4
Leucine aminopeptidase 2

2

2

High-throughput

0.588

High

598827

HOG1
Mitogen-activated protein kinase HOG1

2

10

High-throughput

0.584

High

598882

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

598901

2ABA
Protein phosphatase PP2A regulatory subunit B

2

0

High-throughput

0.576

High

598919

ARPC3
Actin-related protein 2/3 complex subunit 3

2

0

High-throughput

0.576

High

598818

RAD51
DNA repair protein RAD51

2

0

High-throughput

0.563

High

598842

PP2C3
Protein phosphatase 2C homolog 3

2

0

High-throughput

0.563

High

598922

CFT1
Protein CFT1

2

0

High-throughput

0.563

High

598834

RSSA1
Small ribosomal subunit protein uS2A

2

1

High-throughput

0.558

High

510157

HSP77
Import motor subunit, mitochondrial

2

5

High-throughput

0.552

High

598815

SIS1
Protein SIS1

2

2

High-throughput

0.549

High

598833

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

1

High-throughput

0.541

High

598867

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.541

High

598883

LSB3
LAS seventeen-binding protein 3

1

2

High-throughput

0.541

High

437870

KAPC
cAMP-dependent protein kinase type 3

1

5

High-throughput

0.536

High

531233

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

598814

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

1

High-throughput

0.536

High

598828

MKK2
MAP kinase kinase MKK2/SSP33

1

7

High-throughput

0.536

High

598840

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.536

High

598845

EF1G2
Elongation factor 1-gamma 2

1

1

High-throughput

0.536

High

598856

KIC1
Serine/threonine-protein kinase KIC1

1

1

High-throughput

0.536

High

598858

DBP8
ATP-dependent RNA helicase DBP8

1

3

High-throughput

0.536

High

598895

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

598903

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

598916

SML1
Ribonucleotide reductase inhibitor protein SML1

1

1

High-throughput

0.536

High

598925

RBX1
RING-box protein HRT1

1

2

High-throughput

0.536

High

598939

PRP46
Pre-mRNA-splicing factor PRP46

1

5

High-throughput

0.536

High

598940

AHA1
Hsp90 co-chaperone AHA1

1

2

High-throughput

0.536

High

598876

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.521

High

598917

CYK2
Cytokinesis protein 2

1

0

High-throughput

0.518

High

449056

CALM
Calmodulin

1

9

High-throughput

0.515

High

598875

MOB1
DBF2 kinase activator protein MOB1

1

0

High-throughput

0.513

High

598914

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.513

High

598937

SMT3
Ubiquitin-like protein SMT3

1

4

High-throughput

0.504

High

448849

STE7
Serine/threonine-protein kinase STE7

1

6

High-throughput

0.501

High

598813

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

4

High-throughput

0.501

High

598832

IME2
Meiosis induction protein kinase IME2/SME1

1

7

High-throughput

0.501

High

598837

SWE1
Mitosis inhibitor protein kinase SWE1

1

8

High-throughput

0.501

High

598849

AKL1
Serine/threonine-protein kinase AKL1

1

1

High-throughput

0.501

High

598934

RTK1
Probable serine/threonine-protein kinase RTK1

1

8

High-throughput

0.501

High

394199

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.500

High

452806

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.500

High

598806

FKBP
FK506-binding protein 1

1

1

High-throughput

0.500

High

598807

PP11
Serine/threonine-protein phosphatase PP1-1

1

4

High-throughput

0.500

High

598816

MSH3
DNA mismatch repair protein MSH3

1

1

High-throughput

0.500

High

598826

ARP2
Actin-related protein 2

1

2

High-throughput

0.500

High

598831

RPD3
Histone deacetylase RPD3

1

6

Small-scale

0.500

High

598839

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.500

High

598860

UTP9
U3 small nucleolar RNA-associated protein 9

1

1

High-throughput

0.489

High

598863

TEM1
Protein TEM1

1

1

High-throughput

0.489

High

598808

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.479

High

598829

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.479

High

149561

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

364310

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.479

High

364909

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.479

High

368580

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.479

High

392177

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

401868

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

430774

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

2

Small-scale

0.479

High

448631

SNF1
Carbon catabolite-derepressing protein kinase

1

2

Small-scale

0.479

High

454694

KAPR
cAMP-dependent protein kinase regulatory subunit

1

2

Small-scale

0.479

High

464544

PBS2
MAP kinase kinase PBS2

1

7

High-throughput

0.479

High

578783

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

598805

HSP60
Heat shock protein 60, mitochondrial

1

1

Small-scale

0.479

High

598809

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

598812

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

598820

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

598825

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

598835

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

598838

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.479

High

598843

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

1

High-throughput

0.479

High

598844

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

598847

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

598848

GBLP
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.479

High

598853

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.479

High

598857

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

598859

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

598865

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

598873

MLP2
Protein MLP2

1

3

High-throughput

0.479

High

598874

TM108
Protein TMA108

1

2

High-throughput

0.479

High

598881

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

598888

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

598889

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.479

High

598892

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

598899

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

598907

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

598910

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

598911

CTK1
CTD kinase subunit alpha

1

8

High-throughput

0.479

High

598926

SGO1
Shugoshin

1

1

High-throughput

0.479

High

598927

MCA1
Metacaspase-1

1

2

High-throughput

0.479

High

598933

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

598938

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.479

High

598941

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.479

High

598942

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

598924

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

3

High-throughput

0.470

High

598890

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.464

High

434794

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

435748

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

439226

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

514432

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

554752

REV1
DNA repair protein REV1

1

0

High-throughput

0.458

High

558562

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

598817

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

598830

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

598852

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

598868

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

598880

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

598886

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

598891

DUO1
DASH complex subunit DUO1

1

0

High-throughput

0.458

High

598900

ACT
Actin

1

0

Small-scale

0.458

High

598902

MCE1
mRNA-capping enzyme subunit alpha

1

0

High-throughput

0.458

High

598904

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

598915

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

598923

VAM6
Vacuolar morphogenesis protein 6

1

0

Small-scale

0.458

High

598928

RDL2
Thiosulfate sulfurtransferase RDL2, mitochondrial

1

0

High-throughput

0.458

High

598905

UBC7
Ubiquitin-conjugating enzyme E2 7

1

1

High-throughput

0.457

High

598918

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

6

High-throughput

0.457

High

459005

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.457

High

598804

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.457

High

598878

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.457

High

438610

SC160
Protein SCP160

1

2

High-throughput

0.445

High

525842

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

598810

NPR1
Nitrogen permease reactivator protein

1

15

High-throughput

0.445

High

598824

MCM5
Minichromosome maintenance protein 5

1

5

High-throughput

0.445

High

598850

SEA4
SEH-associated protein 4

1

1

High-throughput

0.445

High

598855

YM8C
Uncharacterized deoxyribonuclease YMR262W

1

1

High-throughput

0.445

High

598869

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

598896

HCH1
Hsp90 co-chaperone HCH1

1

2

High-throughput

0.445

High

598897

JJJ1
J protein JJJ1

1

1

High-throughput

0.445

High

598898

CRZ1
Transcriptional regulator CRZ1

1

1

High-throughput

0.445

High

409912

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

433421

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

441681

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

502826

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504017

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

512792

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

598821

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.437

High

598823

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

598841

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

598851

GID4
GID complex substrate-recognition subunit 4

1

1

High-throughput

0.437

High

598862

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

598866

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

598877

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

598885

NU192
Nucleoporin NUP192

1

1

High-throughput

0.437

High

598913

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

598921

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

598929

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

598931

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

598935

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

417020

VDAC1
Non-selective voltage-gated ion channel 1

1

0

High-throughput

0.426

High

597702

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

598887

JSN1
Protein JSN1

1

0

High-throughput

0.426

High

598871

JEM1
DnaJ-like chaperone JEM1

1

4

High-throughput

0.407

High

598908

GCN5
Histone acetyltransferase GCN5

1

2

High-throughput

0.407

High

598909

WDR59
Maintenance of telomere capping protein 5

1

8

High-throughput

0.407

High

598936

CENPH
Inner kinetochore subunit MCM16

1

1

High-throughput

0.407

High

381850

H4
Histone H4

2

0

High-throughput

0.307

High

598854

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

598870

SHO1
High osmolarity signaling protein SHO1

1

0

Small-scale

0.269

Low

598836

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

383495

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

454848

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

512234

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

598819

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

598822

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

598846

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

598864

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.249

Low

598879

MID1
Stretch-activated cation channel MID1

1

0

Small-scale

0.249

Low

598893

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

598912

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.249

Low

598930

RSA1
Ribosome assembly 1 protein

1

0

High-throughput

0.249

Low

598943

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

598803

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.232

Low

598811

SEC15
Exocyst complex component SEC15

1

0

High-throughput

0.232

Low

598861

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.232

Low

598872

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

598884

GWT1
GPI-anchored wall transfer protein 1

1

0

High-throughput

0.232

Low

598906

NUP49
Nucleoporin NUP49/NSP49

1

0

High-throughput

0.232

Low

598920

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025