HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.922

Property	Details
Experiments	15629145, 35384245, 36736316, 24440983
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, microscale thermophoresis
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0001701 - in utero embryonic development GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1290 Hs			1 821
+	Hs
		507843 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR1_HUMAN (1-820): 0: 772: 71.17
+	Rn
		499160 PLCG1_RAT (1-1290): 0: 1299: 96.90		FGFR1_RAT (1-813): 0: 759: 70.73
+	Hs
		580927 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR3_HUMAN (10-821): 0: 731: 65.69
+	Hs
		580926 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR4_HUMAN (22-810): 0: 684: 55.86
+	Hs
		580937 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58
+	Hs
		580965 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		EPHA4_HUMAN (18-794): 4.37e-165: 506: 18.60
+	Hs
		580942 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		UFO_HUMAN (5-818): 3.59e-160: 490: 22.49
+	Hs
		581012 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		NTRK3_HUMAN (166-765): 7.85e-160: 488: 25.31
+	Hs
		581014 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		NTRK2_HUMAN (123-765): 4.81e-153: 469: 23.43
+	Mm
		546302 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		NTRK2_MOUSE (123-765): 2.35e-154: 473: 23.90
+	Rn
		499163 PLCG1_RAT (1-1290): 0: 1299: 96.90		NTRK2_RAT (123-765): 5.12e-154: 472: 23.90
+	Hs
		434135 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		RET_HUMAN (228-816): 2.74e-144: 455: 34.26
+	Hs
		384239 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04
+	Mm
		1112476 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		NTRK1_MOUSE (157-772): 6.34e-146: 450: 25.31
+	Hs
		499230 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		KIT_HUMAN (60-803): 1.89e-130: 415: 25.23
+	Mm
		452188 PLCG2_MOUSE (19-1287): 0: 1131: 50.12		CSF1R_MOUSE (467-753): 2.73e-78: 274: 42.52
+	Hs
		572583 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		VGFR1_HUMAN (5-134): 1.03e-11: 70.9: 16.42
+	Hs
		580949 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		VGFR2_HUMAN (46-363): 1.44e-11: 70.5: 16.82
+	Mm
		729415 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		VGFR2_MOUSE (5-354): 1.61e-11: 70.5: 15.49
+	Mm
		729715 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		VGFR1_MOUSE (5-134): 2.01e-11: 70.1: 17.16