HitPredict

Interactor 1: TNNI1 (P19237)
Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform)
Gene: TNNI1

Interactor 2: TNNC1 (P63316)
Troponin C, slow skeletal and cardiac muscles (TN-C)
Gene: TNNC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

Property	Details
Experiments	15542288, 32296183, 12044157, 18092822, 21988832, unassigned1304
Identification Methods	two hybrid, pull down, x-ray crystallography, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	EF-hand_7~Troponin, EF-hand_8~Troponin
Common GO terms	GO:0003009 - skeletal muscle contraction GO:0005829 - cytosol GO:0005861 - troponin complex GO:0014883 - transition between fast and slow fiber GO:0055010 - ventricular cardiac muscle tissue morphogenesis and 1 others more... GO:0060048 - cardiac muscle contraction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 187 Hs			1 161
+	Hs
		584293 TNNI3_HUMAN (2-180): 2.08e-57: 181: 63.13		TNNC1_HUMAN (1-161): 1.1e-83: 244: 100.00
+	Gg
		455000 Q6S7R6_CHICK (2-180): 2.94e-55: 175: 55.87		TNNC1_CHICK (1-161): 5.83e-83: 243: 98.76
+	Hs
		822795 TNNI2_HUMAN (1-180): 4.41e-55: 174: 58.56		TNNC1_HUMAN (1-161): 1.1e-83: 244: 100.00
+	Hs
		361204 TNNI3_HUMAN (2-180): 2.08e-57: 181: 63.13		TNNC2_HUMAN (1-161): 7.69e-49: 156: 64.60
+	Hs
		361223 Q6FGX2_HUMAN (2-180): 2.08e-57: 181: 63.13		TNNC2_HUMAN (1-161): 7.69e-49: 156: 64.60
+	Oc
		361254 TNNI2_RABIT (1-180): 9.76e-54: 170: 58.56		TNNC2_RABIT (1-161): 6.82e-49: 156: 64.60
+	Dm
		734259 TNNI_DROME (8-165): 1.49e-28: 108: 29.19		CALL_DROME (9-154): 4.48e-24: 93.2: 40.41