HitPredict

Interactor 1: EPOR (P19235)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.857

Property	Details
Experiments	9344843, 11443118, 9129019
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 303
+	Hs
		580917 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		562621 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10
+	Mm
		540269 EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69		PLCG1_MOUSE (5-224): 3.19e-29: 119: 16.95
+	Mm
		540274 EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69		PLCG2_MOUSE (5-192): 3.94e-27: 113: 18.72
+	Hs
		581163 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		GRAP_HUMAN (126-294): 1.63e-24: 100: 19.07
+	Hs
		548635 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		VAV_HUMAN (214-293): 3.43e-15: 77.9: 30.86
+	Hs
		581157 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Mm
		540268 EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69		GRB2_MOUSE (240-295): 1.96e-10: 61.4: 26.32
+	Hs
		500953 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		CRK_HUMAN (3-302): 8.95e-54: 179: 55.21
+	Hs
		560471 PRLR_HUMAN (40-499): 4.21e-85: 276: 18.03		VAV2_HUMAN (14-180): 4.46e-40: 150: 19.80
+	Hs
		500944 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80
+	Hs
		500941 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81
+	Hs
		548629 PRLR_HUMAN (40-499): 4.21e-85: 276: 18.03		VAV_HUMAN (214-293): 3.43e-15: 77.9: 30.86
+	Hs
		500956 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		540459 IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		562545 IL7RA_HUMAN (109-477): 4.76e-65: 219: 15.65		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		682260 IL2RG_HUMAN (15-351): 3.88e-59: 201: 17.35		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		924483 IL5RA_HUMAN (24-301): 7.09e-53: 186: 18.31		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Hs
		924809 CSF3R_HUMAN (14-425): 2.42e-50: 186: 13.92		GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32
+	Mm
		770716 CSF3R_MOUSE (14-399): 4.44e-42: 162: 15.08		GRB2_MOUSE (240-295): 1.96e-10: 61.4: 26.32