Protein: LGR5
Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38)

Gene: LGR5
Organism: Homo sapiens
Interactions: 13
UniProt ID: O75473

Gene Ontology (top 5):
GO:0001942 - hair follicle development
GO:0004888 - transmembrane signaling receptor activity
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

282966

RSPO2
R-spondin-2

2

7

Small-scale

0.806

High

282965

RSPO1
R-spondin-1

1

8

Small-scale

0.747

High

282971

ZNRF3
E3 ubiquitin-protein ligase ZNRF3

2

4

Small-scale

0.737

High

282959

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

282961

RHOQ
Rho-related GTP-binding protein RhoQ

1

5

High-throughput

0.618

High

282962

BASI
Basigin

1

7

High-throughput

0.618

High

282967

RHOU
Rho-related GTP-binding protein RhoU

1

8

High-throughput

0.618

High

282969

RND1
Rho-related GTP-binding protein Rho6

1

4

High-throughput

0.618

High

282970

CNPY3
Protein canopy homolog 3

1

12

High-throughput

0.489

High

282960

A4
Amyloid-beta precursor protein

1

3

Small-scale

0.445

High

282963

DHYS
Deoxyhypusine synthase

1

0

High-throughput

0.279

Low

282964

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.279

Low

282968

LEMD2
LEM domain-containing protein 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025