HitPredict

Interactor 1: MED14 (P19263)
Mediator of RNA polymerase II transcription subunit 14 (Glucose repression regulatory protein 1) (Mediator complex subunit 14)
Gene: RGR1

Interactor 2: SRB8 (P25648)
Mediator of RNA polymerase II transcription subunit 12 (Mediator complex subunit 12) (Suppressor of RNA polymerase B 8)
Gene: SRB8

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	33933450, 16429126, 37968396
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0016592 - mediator complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1082 Sc			1 1427
+	Hs
		225404 MED14_HUMAN (90-558): 1.47e-111: 380: 18.27		MED12_HUMAN (31-271): 1.96e-77: 286: 19.22
+	Hs
		225397 MED14_HUMAN (90-558): 1.47e-111: 380: 18.27		MD12L_HUMAN (31-271): 7.81e-73: 271: 17.34
+	Dm
		1374978 MED14_DROME (87-532): 3.26e-142: 467: 21.21		MED12_DROME (31-219): 9.55e-28: 124: 17.80