HitPredict

Interactor 1: ERF3A (P15170)
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog)
Gene: GSPT1

Interactor 2: ERF3B (Q8IYD1)
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog)
Gene: GSPT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.927

The method score is based on:

Property Details
Experiments 28514442, 33961781, 38334954, 35271311, 34349018
Identification Methods affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains GTP-eEF1A_C~GTP-eEF1A_C, GTP-eEF1A_C~GTP_EFTU, GTP-eEF1A_C~GTP_EFTU_D2, GTP_EFTU~GTP_EFTU, GTP_EFTU~GTP_EFTU_D2, GTP_EFTU_D2~GTP_EFTU_D2
Common GO terms GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0003723 - RNA binding
GO:0003747 - translation release factor activity
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
and 4 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 499
Hs

1 628
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+ Mm
+ Zm
+ Zm
+ Sc
+ Zm
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+ Sc
+ Sp
+ Sc

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Last updated: 11Aug2025