HitPredict

Interactor 1: PRP17 (O60508)
Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17)
Gene: CDC40

Interactor 2: RSMB (P14678)
Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B')
Gene: SNRPB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0071007 - U2-type catalytic step 2 spliceosome GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 579 Hs			1 240
+	Hs
		236208 PRP17_HUMAN (30-579): 1.21e-144: 431: 100.00		RSMN_HUMAN (1-212): 6.6e-39: 136: 92.93
+	Sp
		195174 PRP17_SCHPO (29-579): 2.23e-108: 337: 39.39		RSMB_SCHPO (6-154): 8.5e-19: 81.9: 46.00
+	Sc
		766914 PRP17_YEAST (144-579): 3.75e-98: 308: 34.47		RSMB_YEAST (1-86): 1.31e-24: 98.4: 45.92
+	Hs
		539097 SNR40_HUMAN (324-579): 4.45e-65: 218: 19.85		RSMB_HUMAN (1-168): 6.54e-43: 146: 100.00
+	Hs
		538887 WDR5_HUMAN (95-445): 1.64e-63: 213: 15.54		RSMB_HUMAN (1-168): 6.54e-43: 146: 100.00
+	Hs
		209388 PLRG1_HUMAN (318-579): 9.07e-60: 208: 16.73		RSMB_HUMAN (1-168): 6.54e-43: 146: 100.00
+	Hs
		927996 SNR40_HUMAN (324-579): 4.45e-65: 218: 19.85		RSMN_HUMAN (1-212): 6.6e-39: 136: 92.93
+	Hs
		539186 PRP19_HUMAN (286-487): 8.55e-18: 88.6: 27.32		RSMB_HUMAN (1-168): 6.54e-43: 146: 100.00