HitPredict

Interactor 1: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Interactor 2: UB2G2 (P60604)
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)
Gene: UBE2G2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	36749630
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 475 Hs			1 165
+	Hs
		584907 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03
+	Hs
		584923 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03
+	Hs
		584916 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78
+	Hs
		1336390 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03
+	Hs
		849453 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03
+	Hs
		919870 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03
+	Hs
		895921 TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32		UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78
+	Hs
		895815 TRI68_HUMAN (1-465): 4.52e-148: 433: 42.62		UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78
+	Hs
		849406 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03
+	Hs
		919822 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03
+	Hs
		584902 RO52_HUMAN (1-475): 3.26e-173: 497: 100.00		UB2R1_HUMAN (4-159): 1.54e-43: 145: 49.08
+	Hs
		895876 TRI11_HUMAN (1-473): 3.55e-146: 427: 42.53		UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78
+	Hs
		537142 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03
+	Hs
		536760 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UB2D1_HUMAN (4-164): 3.3e-73: 217: 36.03
+	Hs
		536779 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03
+	Hs
		536772 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78
+	Hs
		895851 TRI58_HUMAN (1-472): 1.06e-141: 416: 43.52		UB2D3_HUMAN (4-164): 1.16e-71: 213: 34.78
+	Hs
		536757 TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17		UBE2A_HUMAN (1-162): 1.72e-67: 203: 38.89
+	Mm
		919925 TRI17_MOUSE (1-471): 1.44e-130: 388: 35.80		UB2D2_MOUSE (4-164): 5.65e-73: 217: 36.03
+	Mm
		895977 TRI17_MOUSE (1-471): 1.44e-130: 388: 35.80		UB2D3_MOUSE (4-164): 1.16e-71: 213: 34.78