HitPredict

Interactor 1: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	29374067, 36749823
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:1990907 - beta-catenin-TCF complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 667 Hs			1 772
+	Hs
		587059 ITF2_HUMAN (1-667): 0: 908: 100.00		TLE1_HUMAN (1-772): 0: 553: 77.96
+	Hs
		1048073 HTF4_HUMAN (3-667): 0: 783: 61.71		TLE3_HUMAN (1-772): 0: 597: 100.00
+	Hs
		587453 TFE2_HUMAN (1-667): 0: 733: 49.71		TLE3_HUMAN (1-772): 0: 597: 100.00
+	Hs
		587452 TFE2_HUMAN (1-667): 0: 733: 49.71		TLE1_HUMAN (1-772): 0: 553: 77.96
+	Hs
		587064 ITF2_HUMAN (1-667): 0: 908: 100.00		TLE5_HUMAN (1-200): 1.39e-100: 310: 62.19
+	Hs
		1092919 HTF4_HUMAN (3-667): 0: 783: 61.71		STRN3_HUMAN (4-768): 3.73e-103: 337: 13.55
+	Mm
		586161 TFE2_MOUSE (1-667): 0: 702: 47.69		TLE6_MOUSE (473-772): 8e-46: 174: 33.66
+	Hs
		1387513 HTF4_HUMAN (3-667): 0: 783: 61.71		SNR40_HUMAN (509-677): 5.37e-09: 60.8: 26.52