Protein: TFE2
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)

Gene: TFE2, TCF3
Organism: Homo sapiens
Interactions: 183
UniProt ID: P15923

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587448

ID2
DNA-binding protein inhibitor ID-2

10

20

Small-scale

0.978

High

587410

TAL1
T-cell acute lymphocytic leukemia protein 1

9

20

Small-scale

0.976

High

587449

ID3
DNA-binding protein inhibitor ID-3

9

20

Small-scale

0.974

High

587424

ID1
DNA-binding protein inhibitor ID-1

8

20

Small-scale

0.971

High

581751

MYOG
Myogenin

6

20

Small-scale

0.947

High

581617

MYOD1
Myoblast determination protein 1

5

20

Small-scale

0.934

High

587477

TWST1
Twist-related protein 1

5

20

Small-scale

0.928

High

587467

NDF1
Neurogenic differentiation factor 1

4

20

Small-scale

0.899

High

587408

TFE2
Transcription factor E2-alpha

4

13

Small-scale

0.882

High

586991

ITF2
Transcription factor 4

3

13

High-throughput

0.863

High

587418

MYF6
Myogenic factor 6

3

20

Small-scale

0.863

High

587460

MESP2
Mesoderm posterior protein 2

3

6

High-throughput

0.861

High

587507

TWST2
Twist-related protein 2

3

20

High-throughput

0.858

High

587526

ASCL3
Achaete-scute homolog 3

3

20

High-throughput

0.858

High

587542

NGN3
Neurogenin-3

3

20

High-throughput

0.855

High

587432

ASCL1
Achaete-scute homolog 1

3

20

Small-scale

0.852

High

354051

HAND1
Heart- and neural crest derivatives-expressed protein 1

3

20

Small-scale

0.849

High

587451

HEN2
Helix-loop-helix protein 2

3

20

High-throughput

0.839

High

587517

FER3L
Fer3-like protein

2

20

High-throughput

0.811

High

587520

MESP1
Mesoderm posterior protein 1

2

6

Small-scale

0.793

High

587436

HAND2
Heart- and neural crest derivatives-expressed protein 2

2

20

Small-scale

0.793

High

587450

HEN1
Helix-loop-helix protein 1

2

20

Small-scale

0.793

High

587513

NGN1
Neurogenin-1

2

20

High-throughput

0.776

High

561205

MYF5
Myogenic factor 5

2

20

Small-scale

0.767

High

587426

ID4
DNA-binding protein inhibitor ID-4

2

20

Small-scale

0.754

High

558951

LYL1
Protein lyl-1

1

20

Small-scale

0.740

High

587508

CBP
CREB-binding protein

6

10

Small-scale

0.740

High

154934

BHE40
Class E basic helix-loop-helix protein 40

1

8

Small-scale

0.713

High

223955

TCF21
Transcription factor 21

1

20

Small-scale

0.713

High

587416

USF1
Upstream stimulatory factor 1

1

6

Small-scale

0.713

High

65869

MSGN1
Mesogenin-1

1

20

High-throughput

0.691

High

253535

MUSC
Musculin

1

20

High-throughput

0.691

High

587461

TCF15
Transcription factor 15

1

20

High-throughput

0.691

High

587480

TAL2
T-cell acute lymphocytic leukemia protein 2

1

20

High-throughput

0.691

High

587488

FIGLA
Factor in the germline alpha

1

20

High-throughput

0.691

High

587490

ASCL4
Achaete-scute homolog 4

1

20

High-throughput

0.691

High

587494

TCF23
Transcription factor 23

1

20

High-throughput

0.691

High

587525

NDF4
Neurogenic differentiation factor 4

1

20

High-throughput

0.691

High

587506

LMX1A
LIM homeobox transcription factor 1-alpha

1

3

Small-scale

0.680

High

587459

EP300
Histone acetyltransferase p300

3

9

Small-scale

0.670

High

587519

HTF4
Transcription factor 12

1

13

Small-scale

0.665

High

587510

KAT2B
Histone acetyltransferase KAT2B

2

3

Small-scale

0.629

High

270231

MTG16
Protein CBFA2T3

2

9

Small-scale

0.624

High

587495

SCX
Basic helix-loop-helix transcription factor scleraxis

1

20

Small-scale

0.621

High

371078

MYC
Myc proto-oncogene protein

1

6

Small-scale

0.618

High

405759

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.618

High

587466

OLIG2
Oligodendrocyte transcription factor 2

1

20

Small-scale

0.618

High

587491

BHA15
Class A basic helix-loop-helix protein 15

1

20

High-throughput

0.618

High

587492

PTF1A
Pancreas transcription factor 1 subunit alpha

1

20

Small-scale

0.618

High

587493

TCF24
Transcription factor 24

1

20

High-throughput

0.618

High

587501

ATOH7
Transcription factor ATOH7

1

20

Small-scale

0.618

High

587505

OLIG1
Oligodendrocyte transcription factor 1

1

20

Small-scale

0.618

High

587512

ATOH1
Transcription factor ATOH1

1

20

Small-scale

0.618

High

587518

ATOH8
Transcription factor ATOH8

1

20

High-throughput

0.618

High

587452

TLE1
Transducin-like enhancer protein 1

2

8

Small-scale

0.602

High

587509

KAT2A
Histone acetyltransferase KAT2A

2

11

Small-scale

0.602

High

587428

SOX2
Transcription factor SOX-2

2

3

Small-scale

0.584

High

587447

RUNX1
Runt-related transcription factor 1

2

1

Small-scale

0.584

High

587463

SKP2
S-phase kinase-associated protein 2

2

0

Small-scale

0.559

High

486918

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.552

High

587481

MAPK3
MAP kinase-activated protein kinase 3

1

1

Small-scale

0.549

High

128754

MEN1
Menin

1

0

Small-scale

0.537

High

128380

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

1

Small-scale

0.536

High

587489

BCOR
BCL-6 corepressor

1

1

High-throughput

0.536

High

587523

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

587435

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.529

High

587443

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.527

High

587437

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.518

High

288063

FOXH1
Forkhead box protein H1

1

2

Small-scale

0.515

High

474451

VIME
Vimentin

1

1

High-throughput

0.515

High

587504

KI18A
Kinesin-like protein KIF18A

1

0

High-throughput

0.513

High

332482

CCDB1
Cyclin-D1-binding protein 1

1

0

Small-scale

0.506

High

130694

TAF4
Transcription initiation factor TFIID subunit 4

1

1

Small-scale

0.501

High

283427

TAD2A
Transcriptional adapter 2-alpha

1

4

Small-scale

0.501

High

587429

MAPK2
MAP kinase-activated protein kinase 2

1

1

Small-scale

0.501

High

587532

DAXX
Death domain-associated protein 6

1

1

Small-scale

0.501

High

587409

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.493

High

587414

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.493

High

587470

CASL
Enhancer of filamentation 1

1

1

Small-scale

0.481

High

169927

AURKA
Aurora kinase A

1

0

High-throughput

0.480

High

283591

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.480

High

587502

GLIS1
Zinc finger protein GLIS1

1

0

High-throughput

0.480

High

587521

NSD3
Histone-lysine N-methyltransferase NSD3

1

0

High-throughput

0.480

High

587534

DACH1
Dachshund homolog 1

1

0

High-throughput

0.480

High

587540

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.480

High

162455

ANM5
Protein arginine N-methyltransferase 5

1

1

High-throughput

0.479

High

172452

XPO1
Exportin-1

1

3

High-throughput

0.479

High

227788

MYO1B
Unconventional myosin-Ib

1

1

High-throughput

0.479

High

246419

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

341517

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.479

High

516004

SETLP
Protein SETSIP

1

1

High-throughput

0.479

High

519715

ANDR
Androgen receptor

1

1

Small-scale

0.479

High

587411

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

587419

TYY1
Transcriptional repressor protein YY1

1

1

High-throughput

0.479

High

587423

C2TA
MHC class II transactivator

1

1

Small-scale

0.479

High

587425

ELK3
ETS domain-containing protein Elk-3

1

2

Small-scale

0.479

High

587427

LEG7
Galectin-7

1

2

High-throughput

0.479

High

587430

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

587440

H4
Histone H4

1

1

High-throughput

0.479

High

587442

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.479

High

587453

TLE3
Transducin-like enhancer protein 3

1

8

High-throughput

0.479

High

587456

MTG8
Protein CBFA2T1

1

9

Small-scale

0.479

High

587468

CUL3
Cullin-3

1

1

High-throughput

0.479

High

587469

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

587478

ELAV1
ELAV-like protein 1

1

1

High-throughput

0.479

High

587485

FILA2
Filaggrin-2

1

1

High-throughput

0.479

High

587487

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

587496

I2BP2
Interferon regulatory factor 2-binding protein 2

1

2

Small-scale

0.479

High

587497

LDB1
LIM domain-binding protein 1

1

2

Small-scale

0.479

High

587511

DDX17
Probable ATP-dependent RNA helicase DDX17

1

2

High-throughput

0.479

High

587514

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

Small-scale

0.479

High

587530

RNF14
E3 ubiquitin-protein ligase RNF14

1

3

Small-scale

0.479

High

587531

DIC
Mitochondrial dicarboxylate carrier

1

1

High-throughput

0.479

High

587533

DDX20
Probable ATP-dependent RNA helicase DDX20

1

6

High-throughput

0.479

High

587535

RCOR1
REST corepressor 1

1

2

High-throughput

0.479

High

587536

TRI33
E3 ubiquitin-protein ligase TRIM33

1

5

Small-scale

0.479

High

587537

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.479

High

565547

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.470

High

162777

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

0

High-throughput

0.458

High

214692

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

0

High-throughput

0.458

High

321173

ERLN2
Erlin-2

1

0

High-throughput

0.458

High

328290

NDUB4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

1

0

High-throughput

0.458

High

370267

CYTA
Cystatin-A

1

0

High-throughput

0.458

High

442573

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.458

High

552909

PIP
Prolactin-inducible protein

1

0

High-throughput

0.458

High

587412

SON
Protein SON

1

0

High-throughput

0.458

High

587415

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

587417

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.458

High

587420

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.458

High

587422

CASPE
Caspase-14

1

0

High-throughput

0.458

High

587433

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

587438

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

587439

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

587441

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

587445

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

587454

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

587455

EF1A2
Elongation factor 1-alpha 2

1

0

High-throughput

0.458

High

587457

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

587462

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

587472

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.458

High

587473

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.458

High

587474

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.458

High

587475

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

587476

SAFB1
Scaffold attachment factor B1

1

0

High-throughput

0.458

High

587483

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.458

High

587486

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.458

High

587498

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

587503

IN80E
INO80 complex subunit E

1

0

High-throughput

0.458

High

587516

ASB2
Ankyrin repeat and SOCS box protein 2

1

0

Small-scale

0.458

High

587524

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.458

High

587527

LANC2
LanC-like protein 2

1

0

High-throughput

0.458

High

587528

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

587543

SPIN1
Spindlin-1

1

0

High-throughput

0.458

High

587413

NUCL
Nucleolin

1

1

Small-scale

0.457

High

587484

KLH22
Kelch-like protein 22

1

2

High-throughput

0.445

High

587538

RUVB2
RuvB-like 2

1

1

High-throughput

0.445

High

587539

RUVB1
RuvB-like 1

1

1

High-throughput

0.445

High

288895

ERAL1
GTPase Era, mitochondrial

1

1

High-throughput

0.437

High

587431

SERPH
Serpin H1

1

1

High-throughput

0.437

High

587471

GSE1
Genetic suppressor element 1

1

1

High-throughput

0.437

High

587482

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.437

High

587515

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

1

High-throughput

0.437

High

587541

TCAF1
TRPM8 channel-associated factor 1

3

0

High-throughput

0.352

High

333743

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

2

0

High-throughput

0.328

High

587500

GT252
Procollagen galactosyltransferase 2

2

0

High-throughput

0.328

High

587464

PLD1
Phospholipase D1

1

0

High-throughput

0.268

Low

299928

CBPD
Carboxypeptidase D

1

0

High-throughput

0.249

Low

417931

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

551943

ADT1
ADP/ATP translocase 1

1

0

High-throughput

0.249

Low

572344

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.249

Low

573918

MYL6B
Myosin light chain 6B

1

0

High-throughput

0.249

Low

587421

CALX
Calnexin

1

0

High-throughput

0.249

Low

587434

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.249

Low

587444

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.249

Low

587446

RL36A
Large ribosomal subunit protein eL42

1

0

High-throughput

0.249

Low

587458

TFF3
Trefoil factor 3

1

0

High-throughput

0.249

Low

587465

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.249

Low

587479

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.249

Low

587499

DJC10
DnaJ homolog subfamily C member 10

1

0

High-throughput

0.249

Low

587522

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.249

Low

587529

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.249

Low

369307

A1AT
Alpha-1-antitrypsin

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025