HitPredict

Interactor 1: FGFR1 (P16092)
Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: FGF21 (Q9JJN1)
Fibroblast growth factor 21 (FGF-21)
Gene: FGF21

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	17452648
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FGF~I-set
Common GO terms	GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation GO:0090080 - positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Mm			1 210
+	Mm
		591456 FGFR1_MOUSE (1-822): 0: 847: 100.00		FGF23_MOUSE (11-210): 3.95e-69: 213: 34.31
+	Hs
		343713 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF19_HUMAN (4-208): 1.64e-70: 215: 34.72
+	Hs
		541676 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF23_HUMAN (11-210): 1.23e-69: 214: 32.04
+	Mm
		591447 FGFR1_MOUSE (1-822): 0: 847: 100.00		FGF9_MOUSE (31-185): 1.78e-57: 182: 26.51
+	Hs
		541358 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF9_HUMAN (31-185): 1.33e-57: 182: 26.51
+	Hs
		532198 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF6_HUMAN (41-168): 1.9e-50: 164: 31.82
+	Hs
		193061 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF10_HUMAN (38-168): 4.23e-49: 160: 27.86
+	Hs
		472376 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF4_HUMAN (14-168): 2.03e-48: 159: 30.82
+	Hs
		541297 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF3_HUMAN (27-204): 4.4e-48: 159: 25.25
+	Hs
		240131 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF17_HUMAN (27-193): 9.29e-46: 152: 19.89
+	Mm
		585425 FGFR1_MOUSE (1-822): 0: 847: 100.00		FGF2_MOUSE (24-168): 1.82e-45: 149: 28.67
+	Hs
		478439 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF2_HUMAN (23-168): 3.07e-44: 150: 28.48
+	Hs
		541299 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF5_HUMAN (46-185): 2.56e-43: 147: 26.97
+	Hs
		426932 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF1_HUMAN (39-170): 7.22e-44: 145: 30.22
+	Hs
		541413 FGFR1_HUMAN (1-822): 0: 844: 98.42		FGF8_HUMAN (46-185): 1.59e-42: 144: 17.12
+	Hs
		193063 FGFR2_HUMAN (1-811): 0: 786: 71.34		FGF10_HUMAN (38-168): 4.23e-49: 160: 27.86
+	Hs
		472382 FGFR2_HUMAN (1-811): 0: 786: 71.34		FGF4_HUMAN (14-168): 2.03e-48: 159: 30.82
+	Hs
		240134 FGFR2_HUMAN (1-811): 0: 786: 71.34		FGF17_HUMAN (27-193): 9.29e-46: 152: 19.89
+	Hs
		478445 FGFR2_HUMAN (1-811): 0: 786: 71.34		FGF2_HUMAN (23-168): 3.07e-44: 150: 28.48
+	Hs
		426937 FGFR2_HUMAN (1-811): 0: 786: 71.34		FGF1_HUMAN (39-170): 7.22e-44: 145: 30.22