HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm GO:0060271 - cilium assembly
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 598
+	Hs
		598260 FLNA_HUMAN (1-2647): 0: 2776: 100.00		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		598209 FLNA_HUMAN (1-2647): 0: 2776: 100.00		WDR5B_HUMAN (40-372): 8.51e-54: 188: 13.41
+	Hs
		598345 FLNA_HUMAN (1-2647): 0: 2776: 100.00		NLE1_HUMAN (374-598): 6.99e-46: 170: 10.26
+	Hs
		597996 FLNA_HUMAN (1-2647): 0: 2776: 100.00		LIS1_HUMAN (6-327): 3.89e-44: 164: 11.60
+	Hs
		598240 FLNA_HUMAN (1-2647): 0: 2776: 100.00		POC1B_HUMAN (428-590): 8.43e-39: 150: 15.39
+	Hs
		598383 FLNA_HUMAN (1-2647): 0: 2776: 100.00		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		598367 FLNA_HUMAN (1-2647): 0: 2776: 100.00		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		598040 FLNA_HUMAN (1-2647): 0: 2776: 100.00		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		261236 FLNB_HUMAN (28-2647): 0: 2710: 69.63		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		1052959 FLNC_HUMAN (32-2647): 0: 1432: 35.96		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		903137 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		957555 PGBM_HUMAN (181-1251): 3.53e-32: 140: 12.81		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88