HitPredict

Interactor 1: EPHA1 (P21709)
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Gene: EPHA1

Interactor 2: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 976 Hs			1 4128
+	Hs
		665578 EPHB2_HUMAN (27-975): 0: 1112: 41.01		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		674388 UFO_HUMAN (274-964): 2.03e-146: 459: 23.29		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		944199 TYRO3_HUMAN (276-964): 4.07e-145: 456: 23.98		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		435610 IGF1R_HUMAN (269-885): 5.75e-137: 446: 21.38		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		944208 MERTK_HUMAN (274-909): 3.08e-140: 446: 24.71		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		872435 EPHA5_HUMAN (3-975): 0: 1117: 41.91		ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42
+	Hs
		600653 EPHA1_HUMAN (1-976): 0: 1103: 100.00		SMG1_HUMAN (3179-4115): 6.6e-124: 444: 16.20