HitPredict

Interactor 1: EPHA1 (P21709)
Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
Gene: EPHA1

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	unassigned1973
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0001525 - angiogenesis GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 509
+	Hs
		1072502 EPHA7_HUMAN (2-975): 0: 1117: 43.22		SHB_HUMAN (1-509): 5.37e-127: 381: 100.00
+	Hs
		666048 EPHA5_HUMAN (3-975): 0: 1117: 41.91		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Mm
		403425 EPHB2_MOUSE (27-975): 0: 1113: 41.01		SRC_MOUSE (264-488): 1.12e-63: 218: 18.64
+	Hs
		666049 EPHA4_HUMAN (5-975): 0: 1108: 43.50		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		522803 EPHB2_HUMAN (27-975): 0: 1112: 41.01		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		209018 EPHA4_HUMAN (5-975): 0: 1108: 43.50		NCK2_HUMAN (157-505): 7.36e-63: 211: 17.45
+	Hs
		522871 EPHA4_HUMAN (5-975): 0: 1108: 43.50		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		557643 EPHA5_HUMAN (3-975): 0: 1117: 41.91		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		412104 EPHA5_HUMAN (3-975): 0: 1117: 41.91		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		433265 EPHB2_HUMAN (27-975): 0: 1112: 41.01		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Mm
		763386 EPHA4_MOUSE (5-975): 0: 1110: 43.50		FYN_MOUSE (283-506): 1.94e-53: 190: 15.16
+	Hs
		412105 EPHA4_HUMAN (5-975): 0: 1108: 43.50		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		872422 EPHA5_HUMAN (3-975): 0: 1117: 41.91		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		924590 EPHA7_HUMAN (2-975): 0: 1117: 43.22		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		665574 EPHB2_HUMAN (27-975): 0: 1112: 41.01		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		789068 EPHA7_HUMAN (2-975): 0: 1117: 43.22		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		665558 EPHB2_HUMAN (27-975): 0: 1112: 41.01		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Mm
		872619 EPHB2_MOUSE (27-975): 0: 1113: 41.01		ABL2_MOUSE (354-487): 1.65e-35: 143: 26.12
+	Hs
		337360 EPHB2_HUMAN (27-975): 0: 1112: 41.01		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Mm
		337625 EPHA4_MOUSE (5-975): 0: 1110: 43.50		ABL1_MOUSE (354-507): 2.92e-35: 142: 24.03