HitPredict

Interactor 1: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18374639, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 821 Hs			1 724
+	Hs
		507870 FGFR1_HUMAN (1-820): 0: 772: 71.17		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		129199 FGFR2_HUMAN (1-821): 0: 863: 100.00		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		609182 FGFR3_HUMAN (10-821): 0: 731: 65.69		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		607886 FGFR4_HUMAN (22-810): 0: 684: 55.86		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		129184 FGFR1_HUMAN (1-820): 0: 772: 71.17		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129201 FGFR4_HUMAN (22-810): 0: 684: 55.86		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		655220 EPHA3_HUMAN (18-778): 3.24e-168: 514: 18.30		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655222 EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		608065 FGFR4_HUMAN (22-810): 0: 684: 55.86		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		129209 EPHA3_HUMAN (18-778): 3.24e-168: 514: 18.30		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129211 EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129253 EPHA4_HUMAN (18-794): 4.37e-165: 506: 18.60		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		253307 FGFR1_HUMAN (1-820): 0: 772: 71.17		SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78
+	Hs
		433229 FGFR1_HUMAN (1-820): 0: 772: 71.17		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Hs
		64660 EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58		RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99
+	Hs
		253317 EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58		SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78
+	Mm
		975149 EPHA4_MOUSE (18-794): 7.05e-166: 508: 18.60		CHIN_MOUSE (87-300): 4.48e-54: 194: 21.10
+	Rn
		88844 D3ZZK3_RAT (18-794): 3.27e-166: 508: 18.60		CHIN_RAT (87-296): 8.17e-54: 190: 21.96
+	Mm
		763386 EPHA4_MOUSE (18-794): 7.05e-166: 508: 18.60		FYN_MOUSE (573-724): 9.83e-33: 135: 22.50
+	Hs
		433265 EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58		YES_HUMAN (568-724): 2.15e-31: 131: 20.61