HitPredict

Interactor 1: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Interactor 2: FCGRN (P55899)
IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
Gene: FCGRT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~Ig_3
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 821 Hs			1 365
+	Hs
		382306 FGFR2_HUMAN (1-821): 0: 863: 100.00		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		382280 FGFR1_HUMAN (1-820): 0: 772: 71.17		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		382308 FGFR4_HUMAN (22-810): 0: 684: 55.86		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		507930 FGFR1_HUMAN (1-820): 0: 772: 71.17		FCGRN_HUMAN (1-365): 7.52e-116: 342: 100.00
+	Hs
		607931 FGFR4_HUMAN (22-810): 0: 684: 55.86		FCGRN_HUMAN (1-365): 7.52e-116: 342: 100.00
+	Hs
		382433 NTRK3_HUMAN (166-765): 7.85e-160: 488: 25.31		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		382268 RET_HUMAN (228-816): 2.74e-144: 455: 34.26		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		382259 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		488237 NTRK3_HUMAN (166-765): 7.85e-160: 488: 25.31		HLAC_HUMAN (1-359): 9.32e-133: 385: 25.95
+	Hs
		488193 ROR2_HUMAN (11-820): 1.91e-156: 482: 20.29		HLAC_HUMAN (1-359): 9.32e-133: 385: 25.95
+	Hs
		570320 ROR2_HUMAN (11-820): 1.91e-156: 482: 20.29		HLAG_HUMAN (1-307): 6.38e-133: 384: 27.36
+	Hs
		533140 ROR2_HUMAN (11-820): 1.91e-156: 482: 20.29		HLAE_HUMAN (20-310): 1.29e-124: 364: 29.14
+	Hs
		673955 NTRK3_HUMAN (166-765): 7.85e-160: 488: 25.31		HLAF_HUMAN (4-343): 2.87e-120: 352: 28.81
+	Hs
		382331 FLT3_HUMAN (342-800): 5.44e-85: 293: 36.15		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		488144 FLT3_HUMAN (342-800): 5.44e-85: 293: 36.15		HLAC_HUMAN (1-359): 9.32e-133: 385: 25.95
+	Hs
		382329 VGFR3_HUMAN (42-385): 5.85e-18: 91.4: 17.62		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		169158 MUSK_HUMAN (34-396): 6.41e-25: 113: 18.43		HLAB_HUMAN (1-357): 1.03e-136: 395: 26.63
+	Hs
		382400 TYRO3_HUMAN (167-367): 4.11e-12: 72.1: 22.55		HLAA_HUMAN (1-360): 8.54e-151: 431: 27.27
+	Hs
		169162 MUSK_HUMAN (34-396): 6.41e-25: 113: 18.43		HLAC_HUMAN (1-359): 9.32e-133: 385: 25.95