HitPredict

Interactor 1: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Interactor 2: KS6A2 (Q15349)
Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)
Gene: RPS6KA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 821 Hs			1 733
+	Hs
		601482 FGFR2_HUMAN (1-821): 0: 863: 100.00		KS6A3_HUMAN (2-733): 0: 798: 79.13
+	Hs
		601517 FGFR2_HUMAN (1-821): 0: 863: 100.00		KS6A1_HUMAN (25-733): 0: 797: 80.11
+	Hs
		508015 FGFR1_HUMAN (1-820): 0: 772: 71.17		KS6A2_HUMAN (1-733): 0: 824: 100.00
+	Hs
		507919 FGFR1_HUMAN (1-820): 0: 772: 71.17		KS6A3_HUMAN (2-733): 0: 798: 79.13
+	Hs
		508016 FGFR1_HUMAN (1-820): 0: 772: 71.17		KS6A1_HUMAN (25-733): 0: 797: 80.11
+	Rn
		979772 FGFR1_RAT (1-813): 0: 759: 70.73		KS6A1_RAT (25-733): 0: 797: 79.55
+	Hs
		609219 FGFR3_HUMAN (10-821): 0: 731: 65.69		KS6A3_HUMAN (2-733): 0: 798: 79.13
+	Hs
		607926 FGFR4_HUMAN (22-810): 0: 684: 55.86		KS6A3_HUMAN (2-733): 0: 798: 79.13
+	Hs
		607975 FGFR4_HUMAN (22-810): 0: 684: 55.86		KS6A1_HUMAN (25-733): 0: 797: 80.11
+	Hs
		608180 FGFR4_HUMAN (22-810): 0: 684: 55.86		KS6A6_HUMAN (21-733): 0: 771: 74.65
+	Hs
		665243 EPHA2_HUMAN (18-798): 4.64e-157: 485: 19.21		KS6A2_HUMAN (1-733): 0: 824: 100.00
+	Hs
		968381 ROR2_HUMAN (11-820): 1.91e-156: 482: 20.29		KS6A2_HUMAN (1-733): 0: 824: 100.00
+	Hs
		434163 RET_HUMAN (228-816): 2.74e-144: 455: 34.26		KS6A3_HUMAN (2-733): 0: 798: 79.13
+	Hs
		507876 FGFR1_HUMAN (1-820): 0: 772: 71.17		AKT1_HUMAN (408-730): 5.21e-125: 382: 26.41
+	Hs
		507838 FGFR1_HUMAN (1-820): 0: 772: 71.17		KAPCA_HUMAN (402-707): 8.01e-119: 362: 29.78
+	Hs
		607895 FGFR4_HUMAN (22-810): 0: 684: 55.86		AKT1_HUMAN (408-730): 5.21e-125: 382: 26.41
+	Hs
		665151 EPHA2_HUMAN (18-798): 4.64e-157: 485: 19.21		AKT1_HUMAN (408-730): 5.21e-125: 382: 26.41
+	Hs
		568557 EPHA2_HUMAN (18-798): 4.64e-157: 485: 19.21		KAPCA_HUMAN (402-707): 8.01e-119: 362: 29.78
+	Hs
		568630 ROR2_HUMAN (11-820): 1.91e-156: 482: 20.29		KAPCA_HUMAN (402-707): 8.01e-119: 362: 29.78
+	Hs
		384267 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		KAPCB_HUMAN (402-707): 4.06e-118: 360: 29.78