HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: HSH2D (Q96JZ2)
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
Gene: HSH2D

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 352
+	Hs
		454797 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FGR_HUMAN (2-207): 1.19e-39: 148: 18.64
+	Hs
		433253 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		YES_HUMAN (2-181): 3.84e-38: 144: 17.07
+	Hs
		602006 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SH22A_HUMAN (17-212): 4.9e-39: 144: 29.35
+	Hs
		522774 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SRC_HUMAN (2-207): 1.8e-36: 139: 17.37
+	Hs
		411594 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57
+	Hs
		442779 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		HCK_HUMAN (15-207): 1.82e-35: 137: 17.97
+	Hs
		275172 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRAP2_HUMAN (3-162): 2.51e-36: 135: 23.21
+	Hs
		601876 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		601919 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PTK6_HUMAN (30-149): 1.47e-32: 127: 28.46
+	Hs
		557604 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK1_HUMAN (1-121): 6.52e-31: 122: 28.46
+	Hs
		601964 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		P55G_HUMAN (13-130): 1.15e-30: 122: 25.41
+	Hs
		562623 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG2_HUMAN (6-159): 1.15e-24: 107: 17.65
+	Hs
		580925 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PLCG1_HUMAN (4-147): 2.82e-24: 106: 21.25
+	Hs
		208992 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		NCK2_HUMAN (13-121): 6.71e-23: 100: 29.20
+	Hs
		601843 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		KSYK_HUMAN (33-142): 8.99e-18: 86.4: 27.59
+	Hs
		601842 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ZAP70_HUMAN (33-139): 9.19e-17: 83.3: 29.20
+	Hs
		412202 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		FYN_HUMAN (3-207): 5.32e-40: 149: 16.81
+	Hs
		411729 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57
+	Hs
		275197 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		GRAP2_HUMAN (3-162): 2.51e-36: 135: 23.21
+	Hs
		209056 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		NCK2_HUMAN (13-121): 6.71e-23: 100: 29.20