Protein: FBLN4
EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)

Gene: FBLN4, EFEMP2
Organism: Homo sapiens
Interactions: 141
UniProt ID: O95967

Gene Ontology (top 5):
GO:0001527 - microfibril
GO:0005201 - extracellular matrix structural constituent
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005604 - basement membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

351510

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

1

17

Small-scale

0.724

High

351616

FBLN5
Fibulin-5

1

20

Small-scale

0.724

High

351567

TRI42
Tripartite motif-containing protein 42

2

15

High-throughput

0.700

High

351527

CREB5
Cyclic AMP-responsive element-binding protein 5

3

7

High-throughput

0.675

High

351514

BAG6
Large proline-rich protein BAG6

3

9

High-throughput

0.667

High

351582

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

5

10

High-throughput

0.663

High

351620

UBQL1
Ubiquilin-1

5

8

High-throughput

0.663

High

351534

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

3

9

High-throughput

0.661

High

351496

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

19

Small-scale

0.647

High

351505

LYOX
Protein-lysine 6-oxidase

2

9

Small-scale

0.646

High

226650

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

4

10

High-throughput

0.644

High

291742

STK16
Serine/threonine-protein kinase 16

3

2

High-throughput

0.616

High

351561

NUFP2
FMR1-interacting protein NUFIP2

3

8

High-throughput

0.616

High

70069

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.606

High

351498

CO3
Complement C3

2

4

High-throughput

0.606

High

351500

RET3
Retinol-binding protein 3

2

1

High-throughput

0.606

High

351502

ITB5
Integrin beta-5

2

6

High-throughput

0.606

High

351503

IBP6
Insulin-like growth factor-binding protein 6

2

16

High-throughput

0.606

High

351512

CXCL5
C-X-C motif chemokine 5

2

2

High-throughput

0.606

High

351559

ATL4
ADAMTS-like protein 4

2

8

High-throughput

0.606

High

351584

HIPL1
HHIP-like protein 1

2

3

High-throughput

0.606

High

351614

NTRI
Neurotrimin

2

2

High-throughput

0.606

High

351511

HPCL1
Hippocalcin-like protein 1

2

0

High-throughput

0.580

High

351597

AP1M1
AP-1 complex subunit mu-1

2

0

High-throughput

0.580

High

351618

S23A1
Solute carrier family 23 member 1

2

0

High-throughput

0.580

High

351515

HXA1
Homeobox protein Hox-A1

2

16

High-throughput

0.577

High

351521

ATX1
Ataxin-1

2

3

High-throughput

0.573

High

351577

RBPMS
RNA-binding protein with multiple splicing

1

1

High-throughput

0.573

High

351501

ELN
Elastin

1

11

Small-scale

0.561

High

188089

MOT6
Monocarboxylate transporter 6

2

4

High-throughput

0.553

High

224924

TLX3
T-cell leukemia homeobox protein 3

2

4

High-throughput

0.553

High

277077

PROP1
Homeobox protein prophet of Pit-1

2

4

High-throughput

0.553

High

351509

OTX1
Homeobox protein OTX1

2

6

High-throughput

0.553

High

351517

MXI1
Max-interacting protein 1

2

3

High-throughput

0.553

High

351519

RM12
Large ribosomal subunit protein bL12m

2

1

High-throughput

0.553

High

351520

LBX1
Transcription factor LBX1

2

2

High-throughput

0.553

High

351524

KR122
Keratin-associated protein 12-2

2

5

High-throughput

0.553

High

351525

KR108
Keratin-associated protein 10-8

2

8

High-throughput

0.553

High

351526

PITX1
Pituitary homeobox 1

2

2

High-throughput

0.553

High

351532

KLF1
Krueppel-like factor 1

2

15

High-throughput

0.553

High

351536

ZN345
Zinc finger protein 345

2

7

High-throughput

0.553

High

351539

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.553

High

351541

ZN699
Zinc finger protein 699

2

19

High-throughput

0.553

High

351545

LCE3E
Late cornified envelope protein 3E

2

5

High-throughput

0.553

High

351546

LCE1C
Late cornified envelope protein 1C

2

4

High-throughput

0.553

High

351547

LCE1E
Late cornified envelope protein 1E

2

3

High-throughput

0.553

High

351548

LCE1A
Late cornified envelope protein 1A

2

2

High-throughput

0.553

High

351549

LCE3A
Late cornified envelope protein 3A

2

3

High-throughput

0.553

High

351550

LCE2C
Late cornified envelope protein 2C

2

2

High-throughput

0.553

High

351553

ZNF57
Zinc finger protein 57

2

20

High-throughput

0.553

High

351556

ZN774
Zinc finger protein 774

2

15

High-throughput

0.553

High

351560

S2548
Solute carrier family 25 member 48

2

1

High-throughput

0.553

High

351565

KR111
Keratin-associated protein 11-1

2

1

High-throughput

0.553

High

351572

LNX1
E3 ubiquitin-protein ligase LNX

2

3

High-throughput

0.553

High

351574

RN138
E3 ubiquitin-protein ligase RNF138

2

4

High-throughput

0.553

High

351578

FBXW5
F-box/WD repeat-containing protein 5

2

1

High-throughput

0.553

High

351579

ARRD3
Arrestin domain-containing protein 3

2

1

High-throughput

0.553

High

351581

ZN837
Zinc finger protein 837

2

11

High-throughput

0.553

High

351586

ZN558
Zinc finger protein 558

2

20

High-throughput

0.553

High

351588

TRIB3
Tribbles homolog 3

2

2

High-throughput

0.553

High

351589

ZN587
Zinc finger protein 587

2

14

High-throughput

0.553

High

351592

F110A
Protein FAM110A

2

1

High-throughput

0.553

High

351594

ZN670
Zinc finger protein 670

2

20

High-throughput

0.553

High

351599

LCE3D
Late cornified envelope protein 3D

2

5

High-throughput

0.553

High

351601

SPY4
Protein sprouty homolog 4

2

5

High-throughput

0.553

High

351603

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

2

High-throughput

0.553

High

351605

ZN768
Zinc finger protein 768

2

17

High-throughput

0.553

High

351610

APC11
Anaphase-promoting complex subunit 11

2

2

High-throughput

0.553

High

351611

RBAK
RB-associated KRAB zinc finger protein

2

7

High-throughput

0.553

High

351613

ZN581
Zinc finger protein 581

2

20

High-throughput

0.553

High

351619

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

2

2

High-throughput

0.553

High

180459

PLS1
Phospholipid scramblase 1

1

9

High-throughput

0.541

High

351504

CO8A1
Collagen alpha-1(VIII) chain

1

5

High-throughput

0.541

High

351507

AQP1
Aquaporin-1

1

1

High-throughput

0.541

High

351518

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

351528

HHEX
Hematopoietically-expressed homeobox protein HHEX

1

3

High-throughput

0.541

High

351583

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

1

4

High-throughput

0.541

High

351608

PLS4
Phospholipid scramblase 4

1

5

High-throughput

0.541

High

351593

RHXF2
Rhox homeobox family member 2

1

1

High-throughput

0.532

High

351513

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

1

High-throughput

0.523

High

351516

MEOX2
Homeobox protein MOX-2

1

6

High-throughput

0.523

High

351523

HDAC4
Histone deacetylase 4

1

3

High-throughput

0.523

High

351551

LCE2D
Late cornified envelope protein 2D

1

2

High-throughput

0.523

High

351535

DGCR6
Protein DGCR6

1

0

High-throughput

0.518

High

351499

P53
Cellular tumor antigen p53

1

2

Small-scale

0.504

High

351587

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

8

High-throughput

0.501

High

171823

ZN263
Zinc finger protein 263

1

20

High-throughput

0.494

High

296947

CCNK
Cyclin-K

1

1

High-throughput

0.494

High

300082

GLRX3
Glutaredoxin-3

1

11

High-throughput

0.494

High

351508

CCND3
G1/S-specific cyclin-D3

1

1

High-throughput

0.494

High

351533

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.494

High

351537

ZN638
Zinc finger protein 638

1

1

High-throughput

0.494

High

351570

CTSR1
Cation channel sperm-associated protein 1

1

14

High-throughput

0.494

High

351573

RHPN1
Rhophilin-1

1

5

High-throughput

0.494

High

351596

ZN426
Zinc finger protein 426

1

20

High-throughput

0.494

High

351598

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

12

High-throughput

0.494

High

351607

PIDD1
p53-induced death domain-containing protein 1

1

4

High-throughput

0.494

High

351609

UBQL4
Ubiquilin-4

1

8

High-throughput

0.494

High

351554

Q6NSM0
NR1D2 protein

1

8

High-throughput

0.470

High

139674

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

12

High-throughput

0.464

High

184673

ATX7
Ataxin-7

1

6

High-throughput

0.464

High

351506

NOS3
Nitric oxide synthase 3

1

2

High-throughput

0.464

High

351522

ATN1
Atrophin-1

1

12

High-throughput

0.464

High

351552

GFI1B
Zinc finger protein Gfi-1b

1

20

High-throughput

0.464

High

351615

RERE
Arginine-glutamic acid dipeptide repeats protein

1

13

High-throughput

0.464

High

351538

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

6

High-throughput

0.439

High

351612

HPBP1
Hsp70-binding protein 1

1

1

High-throughput

0.439

High

351566

Q8IUU6
IL16 protein

1

7

High-throughput

0.417

High

351576

AP2C
Transcription factor AP-2 gamma

1

8

High-throughput

0.417

High

351575

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

3

0

High-throughput

0.352

High

351622

AMMR1
Nuclear protein AMMECR1

3

0

High-throughput

0.348

High

73037

PRR32
Proline-rich protein 32

2

0

High-throughput

0.316

High

351529

TLE5
TLE family member 5

2

0

High-throughput

0.316

High

351530

INCA1
Protein INCA1

2

0

High-throughput

0.316

High

351531

RB40B
Ras-related protein Rab-40B

2

0

High-throughput

0.316

High

351540

DOK7
Protein Dok-7

2

0

High-throughput

0.316

High

351542

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.316

High

351543

KR133
Keratin-associated protein 13-3

2

0

High-throughput

0.316

High

351555

CDPF1
Cysteine-rich DPF motif domain-containing protein 1

2

0

High-throughput

0.316

High

351557

KR261
Keratin-associated protein 26-1

2

0

High-throughput

0.316

High

351558

SPAT8
Spermatogenesis-associated protein 8

2

0

High-throughput

0.316

High

351563

SPA24
Spermatogenesis-associated protein 24

2

0

High-throughput

0.316

High

351564

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

351569

CNNM3
Metal transporter CNNM3

2

0

High-throughput

0.316

High

351580

SACA9
Sperm acrosome-associated protein 9

2

0

High-throughput

0.316

High

351585

HS12B
Heat shock 70 kDa protein 12B

2

0

High-throughput

0.316

High

351590

P2RX7
P2X purinoceptor 7

2

0

High-throughput

0.316

High

351591

MDFI
MyoD family inhibitor

2

0

High-throughput

0.316

High

351595

THAP7
THAP domain-containing protein 7

2

0

High-throughput

0.316

High

351600

KRA32
Keratin-associated protein 3-2

2

0

High-throughput

0.316

High

351602

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.316

High

351568

CCD33
Coiled-coil domain-containing protein 33

2

0

High-throughput

0.304

High

351544

LCE3C
Late cornified envelope protein 3C

1

0

High-throughput

0.299

High

351562

CE024
UPF0461 protein C5orf24

1

0

High-throughput

0.299

High

351497

F107A
Actin-associated protein FAM107A

1

0

High-throughput

0.282

High

351604

RIBC2
RIB43A-like with coiled-coils protein 2

1

0

High-throughput

0.282

High

351606

F124B
Protein FAM124B

1

0

High-throughput

0.282

High

351617

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

0

High-throughput

0.282

High

351621

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.282

High

351571

SPTA3
Spermatogenesis-associated protein 3

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025