Protein: PTN12
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)

Gene: PTN12, PTPN12
Organism: Homo sapiens
Interactions: 142
UniProt ID: Q05209

Gene Ontology (top 5):
GO:0002102 - podosome
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

666079

SHC1
SHC-transforming protein 1

11

20

Small-scale

0.983

High

338312

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.949

High

665869

PTN6
Tyrosine-protein phosphatase non-receptor type 6

5

17

High-throughput

0.912

High

924500

GRB2
Growth factor receptor-bound protein 2

3

20

Small-scale

0.870

High

452398

PGFRB
Platelet-derived growth factor receptor beta

3

20

Small-scale

0.829

High

823374

PAXI
Paxillin

10

15

Small-scale

0.760

High

383760

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

Small-scale

0.757

High

782777

CSK
Tyrosine-protein kinase CSK

2

20

High-throughput

0.754

High

207795

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

6

15

Small-scale

0.735

High

983514

PPIP2
Proline-serine-threonine phosphatase-interacting protein 2

6

13

High-throughput

0.734

High

882255

BCAR1
Breast cancer anti-estrogen resistance protein 1

5

13

Small-scale

0.727

High

983521

VAPA
Vesicle-associated membrane protein-associated protein A

5

5

High-throughput

0.712

High

601500

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.698

High

729643

VGFR2
Vascular endothelial growth factor receptor 2

1

20

High-throughput

0.698

High

983479

PTK7
Inactive tyrosine-protein kinase 7

1

20

High-throughput

0.698

High

983487

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.698

High

384692

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.687

High

411687

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.647

High

788986

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.647

High

972318

TIE2
Angiopoietin-1 receptor

1

20

High-throughput

0.647

High

983476

ACK1
Activated CDC42 kinase 1

1

20

High-throughput

0.647

High

983483

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.647

High

598075

FLNA
Filamin-A

3

3

High-throughput

0.633

High

238955

LPXN
Leupaxin

2

16

High-throughput

0.628

High

435618

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.625

High

601900

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.625

High

607948

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.625

High

968363

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.625

High

983495

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.625

High

983502

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

High-throughput

0.625

High

209035

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.618

High

238399

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

557665

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

580982

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

7

High-throughput

0.618

High

983474

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

18

High-throughput

0.618

High

983475

FAK1
Focal adhesion kinase 1

1

20

High-throughput

0.618

High

310611

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

5

High-throughput

0.611

High

394581

A4
Amyloid-beta precursor protein

2

6

High-throughput

0.602

High

790663

WASP
Actin nucleation-promoting factor WAS

2

10

Small-scale

0.595

High

49636

RHG10
Rho GTPase-activating protein 10

2

3

High-throughput

0.584

High

411361

INSR
Insulin receptor

1

20

High-throughput

0.579

High

441487

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.579

High

200173

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

16

Small-scale

0.573

High

225869

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

3

High-throughput

0.571

High

388394

HSPB1
Heat shock protein beta-1

2

4

High-throughput

0.571

High

436268

RHOC
Rho-related GTP-binding protein RhoC

2

20

High-throughput

0.571

High

489014

H14
Histone H1.4

2

1

High-throughput

0.571

High

503947

HSP7C
Heat shock cognate 71 kDa protein

2

7

High-throughput

0.571

High

515839

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

3

High-throughput

0.571

High

547017

EZRI
Ezrin

2

5

High-throughput

0.571

High

559387

H13
Histone H1.3

2

1

High-throughput

0.571

High

564061

HSP76
Heat shock 70 kDa protein 6

2

7

High-throughput

0.571

High

643848

SYVC
Valine--tRNA ligase

2

2

High-throughput

0.571

High

893335

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

3

High-throughput

0.571

High

900404

RHOA
Transforming protein RhoA

2

20

High-throughput

0.571

High

902406

RL37
Large ribosomal subunit protein eL37

2

1

High-throughput

0.571

High

929830

ACTG
Actin, cytoplasmic 2

2

5

High-throughput

0.571

High

931599

CSK2B
Casein kinase II subunit beta

2

1

High-throughput

0.571

High

944197

PRKDC
DNA-dependent protein kinase catalytic subunit

2

2

High-throughput

0.571

High

983477

DUS4
Dual specificity protein phosphatase 4

2

7

High-throughput

0.571

High

983482

DX39B
Spliceosome RNA helicase DDX39B

2

2

High-throughput

0.571

High

983486

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

3

High-throughput

0.571

High

298973

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.561

High

499258

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.553

High

418198

NPM
Nucleophosmin

2

0

High-throughput

0.547

High

616053

SYWC
Tryptophan--tRNA ligase, cytoplasmic

2

0

High-throughput

0.547

High

678613

METK2
S-adenosylmethionine synthase isoform type-2

2

0

High-throughput

0.547

High

983488

SF3A1
Splicing factor 3A subunit 1

2

0

High-throughput

0.547

High

983494

RBP10
Ran-binding protein 10

2

0

High-throughput

0.547

High

983498

PHF5A
PHD finger-like domain-containing protein 5A

2

0

High-throughput

0.547

High

983501

MGAP
MAX gene-associated protein

2

0

High-throughput

0.547

High

983504

CCAR2
Cell cycle and apoptosis regulator protein 2

2

0

High-throughput

0.547

High

983506

RM50
Large ribosomal subunit protein mL50

2

0

High-throughput

0.547

High

882721

STX17
Syntaxin-17

1

1

High-throughput

0.541

High

960681

FANCC
Fanconi anemia group C protein

1

1

High-throughput

0.541

High

983489

SMAD1
Mothers against decapentaplegic homolog 1

1

2

High-throughput

0.541

High

983493

SFRP4
Secreted frizzled-related protein 4

1

2

High-throughput

0.541

High

983508

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

5

High-throughput

0.541

High

983510

CANB2
Calcineurin subunit B type 2

1

2

High-throughput

0.541

High

983528

ZN510
Zinc finger protein 510

1

1

High-throughput

0.541

High

325144

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.536

High

422383

NFM
Neurofilament medium polypeptide

1

2

High-throughput

0.536

High

928269

DYL1
Dynein light chain 1, cytoplasmic

1

1

High-throughput

0.536

High

265912

FRAT2
GSK-3-binding protein FRAT2

1

0

High-throughput

0.518

High

152152

STX16
Syntaxin-16

1

4

High-throughput

0.508

High

803501

BAG6
Large proline-rich protein BAG6

1

3

High-throughput

0.508

High

983511

SMAD5
Mothers against decapentaplegic homolog 5

1

2

High-throughput

0.508

High

182140

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

10

High-throughput

0.501

High

199511

EFS
Embryonal Fyn-associated substrate

1

12

Small-scale

0.501

High

500959

GHR
Growth hormone receptor

1

20

High-throughput

0.501

High

580226

CADH2
Cadherin-2

1

20

High-throughput

0.501

High

717019

CTNB1
Catenin beta-1

1

20

High-throughput

0.501

High

803900

NSF
Vesicle-fusing ATPase

1

16

High-throughput

0.501

High

983478

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

13

High-throughput

0.501

High

983481

GAB1
GRB2-associated-binding protein 1

1

17

High-throughput

0.501

High

983485

CASL
Enhancer of filamentation 1

1

8

Small-scale

0.501

High

809104

UTRN
Utrophin

1

0

High-throughput

0.486

High

983496

ZFP2
Zinc finger protein ZFP2

1

0

High-throughput

0.486

High

983503

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.486

High

983513

THAP2
THAP domain-containing protein 2

1

0

High-throughput

0.486

High

983520

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.486

High

983529

RBM19
Probable RNA-binding protein 19

1

0

High-throughput

0.486

High

983525

TEN1
Teneurin-1

1

5

Small-scale

0.481

High

205301

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

261245

FLNB
Filamin-B

1

3

High-throughput

0.479

High

320847

HS74L
Heat shock 70 kDa protein 4L

1

9

High-throughput

0.479

High

346592

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

413894

GELS
Gelsolin

1

1

Small-scale

0.479

High

575729

VINC
Vinculin

1

1

High-throughput

0.479

High

592218

RAB5A
Ras-related protein Rab-5A

1

6

High-throughput

0.479

High

658902

MK01
Mitogen-activated protein kinase 1

1

15

High-throughput

0.479

High

739383

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

2

High-throughput

0.479

High

835338

GSK3A
Glycogen synthase kinase-3 alpha

1

3

High-throughput

0.479

High

835687

GSK3B
Glycogen synthase kinase-3 beta

1

11

High-throughput

0.479

High

983484

FLNC
Filamin-C

1

3

High-throughput

0.479

High

983490

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

983491

MK06
Mitogen-activated protein kinase 6

1

16

High-throughput

0.479

High

983497

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

983499

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

983500

CARM1
Histone-arginine methyltransferase CARM1

1

1

High-throughput

0.479

High

983507

WASF1
Actin-binding protein WASF1

1

6

Small-scale

0.479

High

983509

DYL2
Dynein light chain 2, cytoplasmic

1

1

High-throughput

0.479

High

983516

CENPJ
Centromere protein J

1

1

High-throughput

0.479

High

983523

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

983526

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

2

High-throughput

0.479

High

983527

RHG26
Rho GTPase-activating protein 26

1

6

High-throughput

0.479

High

962520

PSG9
Pregnancy-specific beta-1-glycoprotein 9

1

13

High-throughput

0.464

High

606408

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

983512

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

983515

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

983518

CASS4
Cas scaffolding protein family member 4

1

9

High-throughput

0.457

High

73227

B4DZK1
cDNA FLJ50036, weakly similar to Myosin-11

1

1

High-throughput

0.439

High

983519

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

983522

CC180
Coiled-coil domain-containing protein 180

1

1

High-throughput

0.417

High

983480

RM49
Large ribosomal subunit protein mL49

2

0

High-throughput

0.298

High

983517

RM47
Large ribosomal subunit protein uL29m

2

0

High-throughput

0.298

High

983524

DPP2
Dipeptidyl peptidase 2

2

0

High-throughput

0.298

High

351650

GLHA
Glycoprotein hormones alpha chain

1

0

High-throughput

0.265

Low

483630

CSH2
Chorionic somatomammotropin hormone 2

1

0

High-throughput

0.251

Low

983492

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

983505

Q8N5B1
Uncharacterized protein

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024