Protein: LRP4
Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)

Gene: LRP4
Organism: Homo sapiens
Interactions: 77
UniProt ID: O75096

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0001942 - hair follicle development
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

270584

SOST
Sclerostin

3

6

Small-scale

0.886

High

270539

AMRP
Alpha-2-macroglobulin receptor-associated protein

2

10

High-throughput

0.811

High

270591

IGSF5
Immunoglobulin superfamily member 5

1

1

High-throughput

0.691

High

270597

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

4

High-throughput

0.691

High

270544

GDF10
Growth/differentiation factor 10

2

1

High-throughput

0.628

High

270579

NET5
Netrin-5

1

17

High-throughput

0.618

High

270556

ZSC26
Zinc finger and SCAN domain-containing protein 26

3

12

High-throughput

0.609

High

270562

ZN621
Zinc finger protein 621

3

10

High-throughput

0.609

High

270571

ZFP41
Zinc finger protein 41 homolog

3

17

High-throughput

0.609

High

270543

VASP
Vasodilator-stimulated phosphoprotein

2

0

High-throughput

0.585

High

270549

RHOB
Rho-related GTP-binding protein RhoB

2

13

High-throughput

0.584

High

70884

ZBBX
Zinc finger B-box domain-containing protein 1

2

1

High-throughput

0.574

High

270545

FCGRN
IgG receptor FcRn large subunit p51

2

5

High-throughput

0.574

High

270552

ZN816
Zinc finger protein 816

2

2

High-throughput

0.574

High

270560

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

2

High-throughput

0.574

High

270564

Z354C
Zinc finger protein 354C

2

10

High-throughput

0.574

High

270575

ZN563
Zinc finger protein 563

2

3

High-throughput

0.574

High

270578

ZN398
Zinc finger protein 398

2

15

High-throughput

0.574

High

270580

ZN669
Zinc finger protein 669

2

10

High-throughput

0.574

High

270585

ZN408
Zinc finger protein 408

2

10

High-throughput

0.574

High

270586

ZN556
Zinc finger protein 556

2

8

High-throughput

0.574

High

270589

ZN331
Zinc finger protein 331

2

7

High-throughput

0.574

High

270593

ZN224
Zinc finger protein 224

2

4

High-throughput

0.574

High

270599

ZN214
Zinc finger protein 214

2

4

High-throughput

0.574

High

270601

ZSC21
Zinc finger and SCAN domain-containing protein 21

2

10

High-throughput

0.549

High

270554

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.541

High

270535

FST
Follistatin

1

4

High-throughput

0.536

High

270542

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.536

High

270566

SULF2
Extracellular sulfatase Sulf-2

1

2

High-throughput

0.536

High

270590

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.536

High

270537

MX1
Interferon-induced GTP-binding protein Mx1

1

0

High-throughput

0.513

High

270592

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.513

High

270594

WHRN
Whirlin

1

10

Small-scale

0.508

High

270563

PCLI1
PTB-containing, cubilin and LRP1-interacting protein

1

1

Small-scale

0.504

High

270582

LCOR
Ligand-dependent corepressor

1

2

High-throughput

0.494

High

49555

FEZF1
Fez family zinc finger protein 1

1

13

High-throughput

0.489

High

270534

ZNF17
Zinc finger protein 17

1

2

High-throughput

0.489

High

270546

ZN121
Zinc finger protein 121

1

4

High-throughput

0.489

High

270551

EMX2
Homeobox protein EMX2

1

2

High-throughput

0.489

High

270555

ZNF74
Zinc finger protein 74

1

9

High-throughput

0.489

High

270561

IGFL3
Insulin growth factor-like family member 3

1

6

High-throughput

0.489

High

270565

ZN584
Zinc finger protein 584

1

11

High-throughput

0.489

High

270567

ZNF34
Zinc finger protein 34

1

10

High-throughput

0.489

High

270568

AN36B
Ankyrin repeat domain-containing protein 36B

1

9

High-throughput

0.489

High

270569

DB123
Beta-defensin 123

1

3

High-throughput

0.489

High

270572

ZN383
Zinc finger protein 383

1

13

High-throughput

0.489

High

270574

ZN248
Zinc finger protein 248

1

1

High-throughput

0.489

High

270576

WDR20
WD repeat-containing protein 20

1

1

High-throughput

0.489

High

270581

ZN707
Zinc finger protein 707

1

19

High-throughput

0.489

High

270583

ZN778
Zinc finger protein 778

1

4

High-throughput

0.489

High

185287

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

217602

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

270530

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.479

High

270531

RASK
GTPase KRas

1

12

High-throughput

0.479

High

270532

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.479

High

270540

BASI
Basigin

1

5

High-throughput

0.479

High

270541

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

Small-scale

0.479

High

270550

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

High-throughput

0.479

High

270553

CUL3
Cullin-3

1

11

High-throughput

0.479

High

270600

LAMP3
Lysosome-associated membrane glycoprotein 3

1

4

High-throughput

0.479

High

270529

ADCY5
Adenylate cyclase type 5

1

0

High-throughput

0.458

High

270573

ARRD4
Arrestin domain-containing protein 4

1

3

High-throughput

0.445

High

270596

SL9A2
Sodium/hydrogen exchanger 2

1

5

High-throughput

0.445

High

270536

RAB4A
Ras-related protein Rab-4A

1

9

High-throughput

0.437

High

270538

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.437

High

270548

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.437

High

270559

SLX4I
Protein SLX4IP

1

1

Small-scale

0.437

High

270587

SP110
Sp110 nuclear body protein

1

4

High-throughput

0.437

High

270533

GOG8G
Golgin subfamily A member 8G

1

2

High-throughput

0.407

High

270570

BEND7
BEN domain-containing protein 7

3

0

High-throughput

0.347

High

270557

ACSM3
Acyl-coenzyme A synthetase ACSM3, mitochondrial

1

0

High-throughput

0.279

Low

270558

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

270577

FNDC8
Fibronectin type III domain-containing protein 8

1

0

High-throughput

0.279

Low

270588

EXOS5
Exosome complex component RRP46

1

0

High-throughput

0.279

Low

270595

MAP10
Microtubule-associated protein 10

1

0

High-throughput

0.279

Low

270598

SHPK
Sedoheptulokinase

1

0

High-throughput

0.279

Low

270547

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025