HitPredict

Interactor 1: USF1 (P22415)
Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1)
Gene: USF1

Interactor 2: Q6FG41 (Q6FG41)
Protein c-Fos (Cellular oncogene fos)
Gene: FOS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 310 Hs			1 380
+	Hs
		345329 USF1_HUMAN (1-310): 3.09e-117: 342: 100.00		FOS_HUMAN (1-380): 1.68e-84: 263: 100.00
+	Hs
		1079722 USF2_HUMAN (4-304): 1.97e-82: 254: 51.19		Q6FG41_HUMAN (1-380): 1.68e-84: 263: 100.00
+	Hs
		345449 USF2_HUMAN (4-304): 1.97e-82: 254: 51.19		FOS_HUMAN (1-380): 1.68e-84: 263: 100.00
+	Hs
		548222 USF1_HUMAN (1-310): 3.09e-117: 342: 100.00		FOSL1_HUMAN (59-287): 1.43e-34: 130: 37.61
+	Hs
		607840 USF1_HUMAN (1-310): 3.09e-117: 342: 100.00		BATF3_HUMAN (120-228): 1.45e-27: 107: 27.52
+	Hs
		252894 MITF_HUMAN (108-304): 8.28e-39: 145: 21.74		FOS_HUMAN (1-380): 1.68e-84: 263: 100.00
+	Mm
		345595 MYC_MOUSE (110-290): 4.19e-38: 142: 22.28		FOS_MOUSE (1-380): 1.27e-84: 263: 93.68
+	Hs
		548304 USF2_HUMAN (4-304): 1.97e-82: 254: 51.19		FOSL2_HUMAN (2-380): 3.19e-31: 122: 39.54
+	Dm
		1137470 Q9VID4_DROME (26-299): 1.58e-55: 196: 17.61		Q5U8V5_DROME (27-201): 1.02e-32: 125: 17.14
+	Dm
		1249547 Q9VID4_DROME (26-299): 1.58e-55: 196: 17.61		Q8SZT1_DROME (27-201): 2.22e-28: 118: 17.14
+	Hs
		345835 MYC_HUMAN (110-288): 4.45e-37: 139: 21.98		FOSL1_HUMAN (59-287): 1.43e-34: 130: 37.61
+	Hs
		579333 SRBP2_HUMAN (119-304): 2.99e-34: 134: 23.12		ATF6A_HUMAN (4-318): 1.09e-31: 128: 14.03
+	Hs
		345836 MYC_HUMAN (110-288): 4.45e-37: 139: 21.98		FOSL2_HUMAN (2-380): 3.19e-31: 122: 39.54
+	Hs
		1317568 MLX_HUMAN (117-299): 7.95e-31: 119: 21.39		BACH2_HUMAN (14-307): 4.1e-34: 136: 13.65
+	Mm
		956180 TFE3_MOUSE (86-303): 2.04e-35: 136: 18.64		BACH1_MOUSE (4-304): 5.82e-27: 114: 14.16
+	Hs
		345859 MYC_HUMAN (110-288): 4.45e-37: 139: 21.98		JUNB_HUMAN (85-215): 3.19e-25: 106: 19.86
+	Hs
		157254 MLX_HUMAN (117-299): 7.95e-31: 119: 21.39		BACH1_HUMAN (4-295): 1.68e-30: 125: 12.99
+	Hs
		345685 MYC_HUMAN (110-288): 4.45e-37: 139: 21.98		JUN_HUMAN (48-215): 1.19e-23: 102: 16.47
+	Hs
		345885 MYC_HUMAN (110-288): 4.45e-37: 139: 21.98		ATF3_HUMAN (131-215): 4.23e-25: 102: 43.53
+	Hs
		378994 MYCN_HUMAN (106-286): 7.41e-35: 133: 19.13		JUNB_HUMAN (85-215): 3.19e-25: 106: 19.86