Protein: PACN3
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)

Gene: PACN3, PACSIN3
Organism: Homo sapiens
Interactions: 138
UniProt ID: Q9UKS6

Gene Ontology (top 5):
GO:0005543 - phospholipid binding
GO:0005737 - cytoplasm
GO:0005768 - endosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1417659

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

9

16

Small-scale

0.974

High

1461205

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

8

16

Small-scale

0.971

High

1461202

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

3

15

Small-scale

0.855

High

1453795

RAI14
Ankycorbin

2

12

High-throughput

0.811

High

271188

COBL
Protein cordon-bleu

4

6

High-throughput

0.699

High

1200469

COBL1
Cordon-bleu protein-like 1

4

15

High-throughput

0.699

High

1447420

ANLN
Anillin

4

5

High-throughput

0.694

High

593532

PGFRA
Platelet-derived growth factor receptor alpha

1

16

High-throughput

0.691

High

1325147

MILK1
MICAL-like protein 1

3

5

Small-scale

0.667

High

133697

WASL
Actin nucleation-promoting factor WASL

3

20

Small-scale

0.658

High

1105835

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

2

20

Small-scale

0.631

High

1431721

TARA
TRIO and F-actin-binding protein

2

10

High-throughput

0.628

High

1154194

ITSN1
Intersectin-1

1

19

High-throughput

0.621

High

710558

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

1461203

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

6

Small-scale

0.618

High

869527

TNFL6
Tumor necrosis factor ligand superfamily member 6

2

8

Small-scale

0.612

High

948404

KR122
Keratin-associated protein 12-2

2

4

High-throughput

0.606

High

401681

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

3

Small-scale

0.586

High

1197747

MIDN
Midnolin

1

0

High-throughput

0.586

High

538091

HSP7C
Heat shock cognate 71 kDa protein

2

2

Small-scale

0.584

High

164663

TNPO2
Transportin-2

2

0

High-throughput

0.580

High

1281168

CLNK
Cytokine-dependent hematopoietic cell linker

2

2

High-throughput

0.576

High

209915

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

20

Small-scale

0.573

High

221196

SPY2
Protein sprouty homolog 2

1

2

High-throughput

0.573

High

1460091

PP13
Galactoside-binding soluble lectin 13

1

2

High-throughput

0.573

High

397187

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

161106

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

Small-scale

0.561

High

1448395

PICK1
PRKCA-binding protein

1

3

Small-scale

0.561

High

1392083

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

1

High-throughput

0.553

High

1452472

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.552

High

257194

CCD22
Coiled-coil domain-containing protein 22

1

8

High-throughput

0.536

High

277433

TP4A3
Protein tyrosine phosphatase type IVA 3

1

4

High-throughput

0.536

High

292773

RENR
Renin receptor

1

1

High-throughput

0.536

High

706059

CXB2
Gap junction beta-2 protein

1

3

High-throughput

0.536

High

773069

MYH9
Myosin-9

1

4

High-throughput

0.536

High

863023

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

2

High-throughput

0.536

High

866861

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.536

High

1160793

DREB
Drebrin

1

9

High-throughput

0.536

High

1206025

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

14

High-throughput

0.536

High

1250799

MPRIP
Myosin phosphatase Rho-interacting protein

1

12

High-throughput

0.536

High

1280933

CNTRL
Centriolin

1

7

High-throughput

0.536

High

1287150

PATL1
Protein PAT1 homolog 1

1

9

High-throughput

0.536

High

1325463

SYNPO
Synaptopodin

1

7

High-throughput

0.536

High

1347891

RIN3
Ras and Rab interactor 3

1

13

High-throughput

0.536

High

1459745

LIMA1
LIM domain and actin-binding protein 1

1

5

High-throughput

0.536

High

1461208

ADA18
Disintegrin and metalloproteinase domain-containing protein 18

1

20

High-throughput

0.536

High

1461209

MB212
Protein mab-21-like 2

1

4

High-throughput

0.536

High

717639

PDIA3
Protein disulfide-isomerase A3

1

2

High-throughput

0.515

High

978781

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.515

High

1060703

SOS1
Son of sevenless homolog 1

1

9

Small-scale

0.515

High

1060724

SOS2
Son of sevenless homolog 2

1

9

Small-scale

0.515

High

694060

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

1400510

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

1

0

High-throughput

0.513

High

1429672

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.513

High

1461204

PCDGK
Protocadherin gamma-C3

1

0

High-throughput

0.513

High

1461207

POLH
DNA polymerase eta

1

0

High-throughput

0.513

High

1105792

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

20

Small-scale

0.506

High

215957

SYNJ1
Synaptojanin-1

1

12

Small-scale

0.501

High

1050723

DYN1
Dynamin-1

1

20

Small-scale

0.501

High

262168

NOL3
Nucleolar protein 3

1

0

High-throughput

0.493

High

539646

PYGM
Glycogen phosphorylase, muscle form

1

0

High-throughput

0.493

High

848307

MAGA3
Melanoma-associated antigen 3

1

1

High-throughput

0.489

High

1201173

CCD93
Coiled-coil domain-containing protein 93

1

1

High-throughput

0.489

High

186114

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

126865

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

129537

MEN1
Menin

1

1

High-throughput

0.479

High

173535

XPO1
Exportin-1

1

4

High-throughput

0.479

High

219566

WIPF1
WAS/WASL-interacting protein family member 1

1

20

Small-scale

0.479

High

331404

KI20A
Kinesin-like protein KIF20A

1

14

High-throughput

0.479

High

375004

RASH
GTPase HRas

1

16

High-throughput

0.479

High

466518

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

601490

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

620642

NUCL
Nucleolin

1

1

High-throughput

0.479

High

703742

MK01
Mitogen-activated protein kinase 1

1

1

High-throughput

0.479

High

721747

GCH1
GTP cyclohydrolase 1

1

1

Small-scale

0.479

High

838515

GRIA2
Glutamate receptor 2

1

7

Small-scale

0.479

High

838537

GRIA3
Glutamate receptor 3

1

7

Small-scale

0.479

High

842671

WASP
Actin nucleation-promoting factor WAS

1

20

Small-scale

0.479

High

845851

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.479

High

884613

SYCC
Cysteine--tRNA ligase, cytoplasmic

1

4

Small-scale

0.479

High

896928

DYN2
Dynamin-2

1

20

Small-scale

0.479

High

953750

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955740

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

962619

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

978393

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

988810

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1008460

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

20

Small-scale

0.479

High

1035982

KIF23
Kinesin-like protein KIF23

1

9

High-throughput

0.479

High

1059996

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

9

Small-scale

0.479

High

1124569

MAP7
Ensconsin

1

14

High-throughput

0.479

High

1138740

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1141016

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

1151925

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1197589

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

2

High-throughput

0.479

High

1198167

SBK1
Serine/threonine-protein kinase SBK1

1

5

Small-scale

0.479

High

1271045

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1279427

AB1IP
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

1

12

Small-scale

0.479

High

1352157

DYH5
Dynein axonemal heavy chain 5

1

1

High-throughput

0.479

High

1352825

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1366908

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1390223

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

5

Small-scale

0.479

High

1433116

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1433571

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1436545

ECT2
Protein ECT2

1

10

High-throughput

0.479

High

1438233

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1458535

HDAC6
Protein deacetylase HDAC6

1

4

High-throughput

0.479

High

1459264

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1461206

CP131
Centrosomal protein of 131 kDa

1

4

High-throughput

0.479

High

248136

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

362077

AATM
Aspartate aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

644118

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

717362

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.458

High

1256433

SEP14
Septin-14

1

0

High-throughput

0.458

High

1430632

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

211192

CTR4
Cationic amino acid transporter 4

1

3

High-throughput

0.445

High

1010121

DLK1
Protein delta homolog 1

1

1

High-throughput

0.445

High

1227679

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.445

High

1353736

MOT10
Monocarboxylate transporter 10

1

1

High-throughput

0.445

High

1394689

KIRR1
Kin of IRRE-like protein 1

1

1

High-throughput

0.445

High

1408086

SC6A7
Sodium-dependent proline transporter

1

3

High-throughput

0.445

High

1417645

S46A2
Solute carrier family 46 member 2

1

2

High-throughput

0.445

High

1420760

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

106830

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

1215549

FRY
Protein furry homolog

1

1

High-throughput

0.437

High

1335626

Q8NCK5
Glutamate-rich WD repeat-containing protein 1

1

3

High-throughput

0.437

High

1367556

ESR2
Estrogen receptor beta

1

7

High-throughput

0.437

High

337150

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.426

High

1168622

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

0

High-throughput

0.426

High

1198693

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1251203

ZNT10
Calcium/manganese antiporter SLC30A10

1

0

High-throughput

0.426

High

1458325

RHCG
Ammonium transporter Rh type C

1

0

High-throughput

0.426

High

1398020

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.407

High

1246362

TM220
Transmembrane protein 220

1

0

High-throughput

0.279

Low

1391317

CERS2
Ceramide synthase 2

1

0

High-throughput

0.279

Low

1213443

AT7L2
Ataxin-7-like protein 2

1

0

High-throughput

0.251

Low

1294939

ERO1B
ERO1-like protein beta

1

0

High-throughput

0.249

Low

653654

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025