HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: GOLI (Q86XS8)
E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (Goliath homolog) (H-Goliath) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130)
Gene: RNF130

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.561

Property	Details
Experiments	16169070, 36610398
Identification Methods	two hybrid, affinity chromatography technology, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 806 Hs			1 419
+	Hs
		665263 EPHA2_HUMAN (1-788): 0: 595: 21.50		RNF43_HUMAN (19-378): 1.06e-57: 203: 17.87
+	Hs
		872554 EPHB4_HUMAN (1-786): 8.14e-179: 541: 17.79		RN149_HUMAN (25-343): 1.03e-80: 255: 41.85
+	Hs
		385698 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		AMFR_HUMAN (2-346): 7.99e-45: 166: 13.50
+	Hs
		434242 RET_HUMAN (453-801): 9.71e-98: 330: 48.63		RN149_HUMAN (25-343): 1.03e-80: 255: 41.85
+	Hs
		508086 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		GOLI_HUMAN (1-419): 4.48e-123: 365: 100.00
+	Hs
		608031 FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31		GOLI_HUMAN (1-419): 4.48e-123: 365: 100.00
+	Hs
		1031155 PTK7_HUMAN (5-344): 7.72e-26: 116: 20.47		RN128_HUMAN (1-384): 4.57e-89: 278: 36.90
+	Hs
		1031153 PTK7_HUMAN (5-344): 7.72e-26: 116: 20.47		RN149_HUMAN (25-343): 1.03e-80: 255: 41.85
+	Hs
		508106 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		RN149_HUMAN (25-343): 1.03e-80: 255: 41.85
+	Hs
		601546 FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56		RN149_HUMAN (25-343): 1.03e-80: 255: 41.85