Protein: PCNA
Proliferating cell nuclear antigen (PCNA)

Gene: PCNA, POL30
Organism: Saccharomyces cerevisiae S288C
Interactions: 105
UniProt ID: P15873

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000710 - meiotic mismatch repair
GO:0000781 - chromosome, telomeric region
GO:0003677 - DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

586422

PCNA
Proliferating cell nuclear antigen

18

17

Small-scale

0.987

High

586485

POLH
DNA polymerase eta

17

14

Small-scale

0.986

High

554751

REV1
DNA repair protein REV1

7

14

Small-scale

0.957

High

586435

FEN1
Flap endonuclease 1

6

7

Small-scale

0.951

High

416790

DNLI1
DNA ligase 1

6

5

Small-scale

0.944

High

586487

SIZ1
E3 SUMO-protein ligase SIZ1

5

3

Small-scale

0.926

High

586451

RFC5
Replication factor C subunit 5

5

15

Small-scale

0.924

High

586466

RFC2
Replication factor C subunit 2

5

16

Small-scale

0.924

High

586454

RFC1
Replication factor C subunit 1

5

17

Small-scale

0.921

High

586477

UBC9
SUMO-conjugating enzyme UBC9

5

8

Small-scale

0.912

High

586453

RFC3
Replication factor C subunit 3

4

16

Small-scale

0.896

High

586465

RFC4
Replication factor C subunit 4

4

17

Small-scale

0.896

High

586497

SMT3
Ubiquitin-like protein SMT3

4

4

Small-scale

0.883

High

584300

DPOD
DNA polymerase delta catalytic subunit

3

9

Small-scale

0.864

High

533467

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

13

4

Small-scale

0.760

High

557657

SRS2
ATP-dependent DNA helicase SRS2

9

1

Small-scale

0.759

High

586482

MSH6
DNA mismatch repair protein MSH6

11

9

Small-scale

0.757

High

586444

RAD5
DNA repair protein RAD5

9

9

Small-scale

0.754

High

586499

CAF1A
Chromatin assembly factor 1 subunit A

7

3

Small-scale

0.744

High

586434

MSH2
DNA mismatch repair protein MSH2

7

9

Small-scale

0.741

High

586472

DPOD3
DNA polymerase delta subunit 3

15

0

Small-scale

0.730

High

586493

ELG1
Telomere length regulation protein ELG1

5

18

Small-scale

0.721

High

586455

RRM3
ATP-dependent DNA helicase RRM3

5

2

Small-scale

0.720

High

586470

ECO1
N-acetyltransferase ECO1

5

2

Small-scale

0.704

High

586461

YEN1
Holliday junction resolvase YEN1

1

7

High-throughput

0.691

High

586450

APN2
DNA-(apurinic or apyrimidinic site) endonuclease 2

4

3

Small-scale

0.685

High

586463

WRIP1
DNA-dependent ATPase MGS1

1

18

Small-scale

0.680

High

556977

UNG
Uracil-DNA glycosylase

3

2

Small-scale

0.672

High

586445

RAD54
DNA repair and recombination protein RAD54

3

2

Small-scale

0.662

High

586475

CTF18
Chromosome transmission fidelity protein 18

1

20

Small-scale

0.647

High

586496

SIZ2
E3 SUMO-protein ligase SIZ2

1

3

Small-scale

0.647

High

454512

PIF1
ATP-dependent DNA helicase PIF1

2

2

Small-scale

0.643

High

586439

MCM10
Minichromosome maintenance protein 10

3

0

Small-scale

0.632

High

586430

MSH3
DNA mismatch repair protein MSH3

3

9

Small-scale

0.623

High

438518

UBC2
Ubiquitin-conjugating enzyme E2 2

1

4

Small-scale

0.621

High

454646

RAD2
DNA repair protein RAD2

1

7

Small-scale

0.618

High

509375

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

6

Small-scale

0.618

High

571288

DPOZ
DNA polymerase zeta catalytic subunit

1

9

Small-scale

0.618

High

586488

CAF1B
Chromatin assembly factor 1 subunit B

3

0

Small-scale

0.613

High

586457

MLH1
DNA mismatch repair protein MLH1

2

5

Small-scale

0.605

High

586446

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.586

High

586478

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

3

Small-scale

0.584

High

586492

ULS1
ATP-dependent helicase ULS1

1

8

Small-scale

0.552

High

586464

RT106
Histone chaperone RTT106

2

0

Small-scale

0.547

High

402183

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

1

High-throughput

0.536

High

586432

RAD51
DNA repair protein RAD51

1

1

Small-scale

0.527

High

585843

CSK21
Casein kinase II subunit alpha

1

9

High-throughput

0.515

High

440821

KIN28
Serine/threonine-protein kinase KIN28

1

7

High-throughput

0.501

High

571271

PMS1
DNA mismatch repair protein PMS1

1

5

Small-scale

0.501

High

586468

CAK1
Serine/threonine-protein kinase CAK1

1

9

High-throughput

0.501

High

586483

SCC2
Sister chromatid cohesion protein 2

1

1

Small-scale

0.501

High

586441

MKK2
MAP kinase kinase MKK2/SSP33

1

6

High-throughput

0.489

High

586476

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

2

High-throughput

0.489

High

586471

DPOD2
DNA polymerase delta small subunit

1

4

Small-scale

0.481

High

586452

MMS4
Crossover junction endonuclease MMS4

1

0

Small-scale

0.480

High

586456

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

1

0

Small-scale

0.480

High

586459

POP2
Poly(A) ribonuclease POP2

1

0

Small-scale

0.480

High

586484

SAS4
Something about silencing protein 4

1

0

Small-scale

0.480

High

586486

MUS81
Crossover junction endonuclease MUS81

1

0

Small-scale

0.480

High

586490

RT109
Histone acetyltransferase RTT109

1

0

Small-scale

0.480

High

586501

SAS5
Something about silencing protein 5

1

0

Small-scale

0.480

High

392161

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.479

High

586426

RFA1
Replication factor A protein 1

1

3

High-throughput

0.479

High

586427

MCM3
DNA replication licensing factor MCM3

1

3

Small-scale

0.479

High

586440

PSA5
Proteasome subunit alpha type-5

1

3

High-throughput

0.479

High

586448

MCM7
DNA replication licensing factor MCM7

1

3

High-throughput

0.479

High

586460

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

5

Small-scale

0.479

High

586469

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

3

High-throughput

0.479

High

586494

MLH3
DNA mismatch repair protein MLH3

1

5

High-throughput

0.479

High

586423

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

586425

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

586428

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

Small-scale

0.458

High

586429

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

586433

YIH1
Protein IMPACT homolog

1

0

High-throughput

0.458

High

586436

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

586438

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

586447

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

586458

REV7
DNA polymerase zeta processivity subunit

1

0

Small-scale

0.458

High

586473

HGH1
Protein HGH1

1

0

Small-scale

0.458

High

586479

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

586481

CTF4
DNA polymerase alpha-binding protein

1

0

Small-scale

0.458

High

586489

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

586495

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

586498

PSF1
DNA replication complex GINS protein PSF1

1

0

Small-scale

0.458

High

586500

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.458

High

560644

KIN2
Serine/threonine-protein kinase KIN2

1

1

High-throughput

0.457

High

586437

MSB2
Signaling mucin MSB2

1

2

Small-scale

0.457

High

416362

HXKA
Hexokinase-1

1

2

High-throughput

0.457

High

452801

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.457

High

554870

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.457

High

554996

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.457

High

586424

HXKG
Glucokinase-1

1

2

High-throughput

0.457

High

380949

H2B1
Histone H2B.1

1

2

High-throughput

0.445

High

586462

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

586480

H3
Histone H3

1

2

High-throughput

0.445

High

578770

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.437

High

586442

ZUO1
Zuotin

1

0

High-throughput

0.426

High

586443

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.279

Low

586431

ELO2
Fatty acid elongase 2

1

0

Small-scale

0.261

Low

425102

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.261

Low

586491

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.261

Low

586449

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

586467

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.232

Low

586474

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025