Protein: UBC9
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (Ubiquitin carrier protein 9) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase)

Gene: UBC9
Organism: Saccharomyces cerevisiae S288C
Interactions: 148
UniProt ID: P50623

Gene Ontology (top 5):
GO:0000022 - mitotic spindle elongation
GO:0000794 - condensed nuclear chromosome
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0016925 - protein sumoylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

897501

SIZ1
E3 SUMO-protein ligase SIZ1

12

14

Small-scale

0.981

High

897523

SIZ2
E3 SUMO-protein ligase SIZ2

11

14

Small-scale

0.976

High

897526

SMT3
Ubiquitin-like protein SMT3

10

19

Small-scale

0.972

High

897480

UBA2
Ubiquitin-activating enzyme E1-like

6

20

Small-scale

0.950

High

801135

NSE2
E3 SUMO-protein ligase MMS21

8

0

Small-scale

0.916

High

586477

PCNA
Proliferating cell nuclear antigen

5

8

Small-scale

0.912

High

533479

RAD18
Postreplication repair E3 ubiquitin-protein ligase RAD18

3

20

Small-scale

0.863

High

897479

UBC9
SUMO-conjugating enzyme UBC9

3

16

Small-scale

0.847

High

897514

RHC31
DNA damage tolerance protein RHC31

3

20

Small-scale

0.845

High

897513

ESC2
Protein ESC2

3

0

Small-scale

0.806

High

746096

RAD5
DNA repair protein RAD5

1

12

Small-scale

0.713

High

763287

SGS1
ATP-dependent helicase SGS1

4

3

Small-scale

0.676

High

649508

UBA1
Ubiquitin-activating enzyme E1 1

1

20

Small-scale

0.647

High

897481

IMB5
Importin subunit beta-5

1

7

Small-scale

0.647

High

557746

SRS2
ATP-dependent DNA helicase SRS2

2

3

Small-scale

0.622

High

438541

UBC2
Ubiquitin-conjugating enzyme E2 2

1

15

Small-scale

0.621

High

815651

LIS1
Nuclear distribution protein PAC1

1

10

Small-scale

0.621

High

818089

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

2

Small-scale

0.621

High

584379

GCN2
eIF-2-alpha kinase GCN2

1

6

High-throughput

0.618

High

793954

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

11

High-throughput

0.618

High

897500

SXM1
Importin beta SMX1

1

7

High-throughput

0.618

High

897505

ERB1
Ribosome biogenesis protein ERB1

1

6

High-throughput

0.618

High

897515

YL419
Putative ATP-dependent RNA helicase YLR419W

1

3

High-throughput

0.618

High

448463

RAD52
DNA repair and recombination protein RAD52

2

3

Small-scale

0.594

High

897496

NSE5
Non-structural maintenance of chromosome element 5

2

0

Small-scale

0.587

High

745526

MRE11
Double-strand break repair protein MRE11

2

2

Small-scale

0.584

High

897502

EUC1
Transcription factor-like protein EUC1

2

0

Small-scale

0.561

High

864297

NET1
Nucleolar protein NET1

1

1

High-throughput

0.561

High

738759

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

2

0

Small-scale

0.559

High

858380

STU2
Protein STU2

2

1

Small-scale

0.556

High

819244

SSB2
Ribosome-associated molecular chaperone SSB2

2

8

High-throughput

0.552

High

737102

CDC11
Cell division control protein 11

2

7

Small-scale

0.549

High

737009

CDC3
Cell division control protein 3

2

6

Small-scale

0.543

High

548223

BIK1
Nuclear fusion protein BIK1

1

2

Small-scale

0.527

High

739307

KAR9
Karyogamy protein KAR9

1

1

Small-scale

0.527

High

897491

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.512

High

625032

PRP6
Pre-mRNA-splicing factor 6

1

2

High-throughput

0.508

High

675345

RAD51
DNA repair protein RAD51

1

5

High-throughput

0.508

High

744503

KA122
Importin beta-like protein KAP122

1

0

Small-scale

0.504

High

897509

CST9
Chromosome stability protein 9

1

0

Small-scale

0.504

High

721642

RENT1
ATP-dependent helicase NAM7

1

1

Small-scale

0.501

High

795778

HEK2
Heterogeneous nuclear rnp K-like protein 2

1

3

Small-scale

0.501

High

817315

YEN1
Holliday junction resolvase YEN1

1

2

Small-scale

0.501

High

897489

CDC14
Tyrosine-protein phosphatase CDC14

1

2

High-throughput

0.501

High

897524

RAD59
DNA repair protein RAD59

1

3

Small-scale

0.501

High

571317

RED1
Protein RED1

1

0

Small-scale

0.486

High

738488

NUP2
Nucleoporin NUP2

1

5

Small-scale

0.481

High

745485

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

2

Small-scale

0.481

High

816964

BIM1
Protein BIM1

1

2

Small-scale

0.481

High

824850

NDC80
Kinetochore protein NDC80

1

2

High-throughput

0.481

High

897518

SLK19
Kinetochore protein SLK19

1

4

High-throughput

0.481

High

829883

MSH4
MutS protein homolog 4

1

0

Small-scale

0.480

High

448986

TOP2
DNA topoisomerase 2

1

2

High-throughput

0.479

High

554714

YPK1
Serine/threonine-protein kinase YPK1

1

2

High-throughput

0.479

High

616435

SEC18
Vesicular-fusion protein SEC18

1

3

High-throughput

0.479

High

632812

DBP5
ATP-dependent RNA helicase DBP5

1

3

High-throughput

0.479

High

644956

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.479

High

645468

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

678981

NOT1
General negative regulator of transcription subunit 1

1

1

High-throughput

0.479

High

743112

STH1
Nuclear protein STH1/NPS1

1

2

High-throughput

0.479

High

746645

DRS1
ATP-dependent RNA helicase DRS1

1

3

High-throughput

0.479

High

791074

NOP4
Nucleolar protein 4

1

1

High-throughput

0.479

High

801872

KSP1
Serine/threonine-protein kinase KSP1

1

6

High-throughput

0.479

High

807009

SPP41
Protein SPP41

1

4

High-throughput

0.479

High

815766

SAP1
Protein SAP1

1

6

High-throughput

0.479

High

816864

NUG1
Nuclear GTP-binding protein NUG1

1

1

High-throughput

0.479

High

830140

NOP2
25S rRNA

1

1

High-throughput

0.479

High

852578

ROK1
ATP-dependent RNA helicase ROK1

1

2

High-throughput

0.479

High

897484

NOP13
Nucleolar protein 13

1

3

High-throughput

0.479

High

897486

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

897487

EF3B
Elongation factor 3B

1

1

High-throughput

0.479

High

897495

HAS1
ATP-dependent RNA helicase HAS1

1

2

High-throughput

0.479

High

897497

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

1

High-throughput

0.479

High

897498

HMO1
High mobility group protein 1

1

9

High-throughput

0.479

High

897508

ARP9
Actin-like protein ARP9

1

3

High-throughput

0.479

High

897511

FKBP4
FK506-binding protein 4

1

1

High-throughput

0.479

High

897516

TSR1
Ribosome biogenesis protein TSR1

1

3

High-throughput

0.479

High

897527

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.479

High

780966

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.460

High

865896

BIR1
Chromosomal passenger complex protein BIR1

1

0

High-throughput

0.460

High

897503

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.460

High

150114

YH11B
Transposon Ty1-H Gag-Pol polyprotein

1

0

High-throughput

0.458

High

459130

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

482055

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

673113

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.458

High

725970

SWC3
SWR1-complex protein 3

1

0

High-throughput

0.458

High

734828

SRP21
Signal recognition particle subunit SRP21

1

0

High-throughput

0.458

High

736521

SFP1
Transcription factor SFP1

1

0

High-throughput

0.458

High

749695

TYE7
Transcription factor TYE7

1

0

High-throughput

0.458

High

781685

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.458

High

791914

AAP1
Alanine/arginine aminopeptidase

1

0

High-throughput

0.458

High

800962

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.458

High

805611

LSM12
Protein LSM12

1

0

High-throughput

0.458

High

806977

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.458

High

814344

NOC2
Nucleolar complex protein 2

1

0

High-throughput

0.458

High

845897

UAP1
UDP-N-acetylglucosamine pyrophosphorylase

1

0

High-throughput

0.458

High

897483

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

897493

RLI1
Translation initiation factor RLI1

1

0

High-throughput

0.458

High

897494

VPS72
Vacuolar protein sorting-associated protein 72

1

0

High-throughput

0.458

High

897499

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.458

High

897510

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

897512

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

897520

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.458

High

524537

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

545537

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

741963

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

809156

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.438

High

368179

THDH
Threonine dehydratase, mitochondrial

1

3

High-throughput

0.437

High

587322

ABP1
Actin-binding protein

1

1

High-throughput

0.437

High

672258

CDC10
Cell division control protein 10

1

7

High-throughput

0.437

High

673336

TRX3
Thioredoxin-3, mitochondrial

1

2

High-throughput

0.437

High

734780

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

1

High-throughput

0.437

High

737332

CDC12
Cell division control protein 12

1

6

High-throughput

0.437

High

738405

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.437

High

779496

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.437

High

796602

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.437

High

799688

TSL1
Trehalose synthase complex regulatory subunit TSL1

1

1

High-throughput

0.437

High

815315

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

4

High-throughput

0.437

High

820999

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

1

High-throughput

0.437

High

850732

COPD
Coatomer subunit delta

1

1

High-throughput

0.437

High

897482

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

1

High-throughput

0.437

High

897488

DNM1
Dynamin-related protein DNM1

1

2

High-throughput

0.437

High

897490

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

1

High-throughput

0.437

High

897492

NOG1
Nucleolar GTP-binding protein 1

1

10

High-throughput

0.437

High

897506

RRP5
rRNA biogenesis protein RRP5

1

1

High-throughput

0.437

High

897517

NOP12
Nucleolar protein 12

1

2

High-throughput

0.437

High

897519

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.437

High

897522

LEU9
2-isopropylmalate synthase 2, mitochondrial

1

1

High-throughput

0.437

High

897485

INN1
Ingression protein 1

1

0

Small-scale

0.282

High

829975

CBF3B
Centromere DNA-binding protein complex CBF3 subunit B

1

0

Small-scale

0.265

Low

817212

FIR1
Factor interacting with REF2

1

0

Small-scale

0.251

Low

432019

ATPF
ATP synthase subunit 4, mitochondrial

1

0

High-throughput

0.249

Low

456540

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

1

0

High-throughput

0.249

Low

670191

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.249

Low

676819

BUD3
Bud site selection protein 3

1

0

High-throughput

0.249

Low

713503

TRXB1
Thioredoxin reductase 1

1

0

High-throughput

0.249

Low

782384

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.249

Low

796244

CST26
2-acyl-1-lysophosphatidylinositol acyltransferase

1

0

High-throughput

0.249

Low

801727

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.249

Low

801756

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.249

Low

812199

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.249

Low

815826

BEM2
GTPase-activating protein BEM2/IPL2

1

0

High-throughput

0.249

Low

844535

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

897504

TMA64
Translation machinery-associated protein 64

1

0

High-throughput

0.249

Low

897507

CYK2
Cytokinesis protein 2

1

0

High-throughput

0.249

Low

897521

MRH1
Protein MRH1

1

0

High-throughput

0.249

Low

897525

RDL1
Thiosulfate:glutathione sulfurtransferase

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025