HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	0.60	0.764

Property	Details
Experiments	31120930, 9857068, 11331248, 15577829, 11742985, 10570266, 11042121, 15536084, 10617633, 8621719, 12435267, 16289966, 15556646, 7721825, 18273061
Identification Methods	enzymatic study, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, experimental interaction detection, x-ray crystallography, isothermal titration calorimetry, coimmunoprecipitation
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043303 - mast cell degranulation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 635
+	Hs
		610285 CBL_HUMAN (1-906): 0: 917: 100.00		ZAP70_HUMAN (6-635): 0: 535: 53.57
+	Hs
		610314 CBL_HUMAN (1-906): 0: 917: 100.00		EPHB1_HUMAN (218-632): 1.32e-117: 375: 27.87
+	Hs
		610244 CBL_HUMAN (1-906): 0: 917: 100.00		EPHA2_HUMAN (242-629): 6.67e-111: 357: 28.83
+	Hs
		610373 CBL_HUMAN (1-906): 0: 917: 100.00		ITK_HUMAN (136-626): 3.44e-108: 341: 27.60
+	Hs
		411595 CBL_HUMAN (1-906): 0: 917: 100.00		LCK_HUMAN (5-201): 3.03e-71: 240: 23.29
+	Hs
		522778 CBL_HUMAN (1-906): 0: 917: 100.00		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		412013 CBL_HUMAN (1-906): 0: 917: 100.00		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		433254 CBL_HUMAN (1-906): 0: 917: 100.00		YES_HUMAN (4-203): 1.25e-68: 234: 20.80
+	Hs
		442780 CBL_HUMAN (1-906): 0: 917: 100.00		HCK_HUMAN (4-371): 1.18e-67: 231: 14.65
+	Hs
		337348 CBL_HUMAN (1-906): 0: 917: 100.00		ABL1_HUMAN (4-385): 1.81e-58: 214: 17.07
+	Hs
		69201 CBL_HUMAN (1-906): 0: 917: 100.00		A9UF07_HUMAN (4-193): 4.67e-58: 214: 18.61
+	Hs
		610366 CBL_HUMAN (1-906): 0: 917: 100.00		FAK1_HUMAN (344-626): 1.88e-57: 211: 39.30
+	Hs
		610410 CBL_HUMAN (1-906): 0: 917: 100.00		ERBB4_HUMAN (375-619): 7.14e-57: 210: 43.15
+	Hs
		337933 CBL_HUMAN (1-906): 0: 917: 100.00		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		610281 CBL_HUMAN (1-906): 0: 917: 100.00		ABL2_HUMAN (4-193): 3.72e-56: 207: 19.54
+	Hs
		383609 CBL_HUMAN (1-906): 0: 917: 100.00		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34
+	Hs
		610402 CBL_HUMAN (1-906): 0: 917: 100.00		FAK2_HUMAN (374-630): 9.56e-53: 197: 40.15
+	Mm
		337618 CBL_MOUSE (1-906): 0: 888: 91.59		ABL1_MOUSE (4-384): 1.19e-58: 215: 16.75
+	Hs
		610226 CBL_HUMAN (1-906): 0: 917: 100.00		JAK1_HUMAN (312-632): 4.51e-39: 156: 20.81
+	Hs
		610303 CBL_HUMAN (1-906): 0: 917: 100.00		BLK_HUMAN (162-267): 2.8e-29: 123: 32.43