HitPredict

Interactor 1: PRS7 (P35998)
26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2)
Gene: PSMC2

Interactor 2: PRS4 (P62191)
26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)
Gene: PSMC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 26496610, 10625621, 23212908, 33961781, 36652389, 39358380, 31839598, 40437099, 19490896, 26186194, 28514442, 30217970, 28292943, 11361004, 35271311, 34349018, 35235311, 37071682, 39422127, 21628461 and 2 others

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Identification Methods affinity chromatography technology, pull down, cross-linking study, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains AAA~AAA, AAA~AAA_lid_3, AAA~Prot_ATP_ID_OB_C, AAA_lid_3~AAA_lid_3, AAA~PRS7_OB, PRS7_OB~Prot_ATP_ID_OB_C
Common GO terms GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 433
Hs

1 440
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+ Rn
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Last updated: 11Aug2025