HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	36470425, 21203488, 19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 375
+	Hs
		610429 CBL_HUMAN (1-906): 0: 917: 100.00		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		610346 CBL_HUMAN (1-906): 0: 917: 100.00		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		610343 CBL_HUMAN (1-906): 0: 917: 100.00		ACTH_HUMAN (2-375): 0: 589: 93.58
+	Hs
		554315 MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		1122431 SRCAP_HUMAN (395-900): 3.05e-09: 63.4: 10.50		ACTBL_HUMAN (2-375): 0: 735: 91.71
+	Hs
		203220 SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		554290 MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58		ACTA_HUMAN (2-375): 0: 591: 94.12
+	Hs
		891853 SRCAP_HUMAN (395-900): 3.05e-09: 63.4: 10.50		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		929905 SRCAP_HUMAN (395-900): 3.05e-09: 63.4: 10.50		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		932156 MDC1_HUMAN (450-878): 1.89e-11: 70.3: 9.33		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		932219 SRCAP_HUMAN (395-900): 3.05e-09: 63.4: 10.50		ACTC_HUMAN (2-375): 0: 592: 94.12