HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	0.60	0.770

Property	Details
Experiments	25472714, 11894096, 28514442, 11071869, 31980649, 11894095, 33961781, 33627783, 15456872, 12135478, 20130058, 22262777, 19531213, 19417776, 19268472, 17306257, 16228008, 14596919, 12618476, 10679202 and 17 others more... 22833562, 17675467, 24167568, 29589748, 25005938, 12177062, 11152963, 16407834, 15107835, 21830225, 12874286, 17072306, 25036637, unassigned2173, 15090612, 15962011, 20711168
Identification Methods	pull down, affinity chromatography technology, unspecified method, x-ray crystallography, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, isothermal titration calorimetry, nuclear magnetic resonance, two hybrid and 1 others more... coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 665
+	Mm
		610630 CBL_MOUSE (1-906): 0: 888: 91.59		SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59
+	Hs
		610540 CBL_HUMAN (1-906): 0: 917: 100.00		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		47590 CBL_HUMAN (1-906): 0: 917: 100.00		A0A8V8TNS8_HUMAN (1-424): 1.15e-82: 269: 90.80
+	Hs
		557607 CBL_HUMAN (1-906): 0: 917: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		610338 CBL_HUMAN (1-906): 0: 917: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		610437 CBL_HUMAN (1-906): 0: 917: 100.00		Q6ICN0_HUMAN (2-158): 1.22e-31: 124: 19.91
+	Hs
		610517 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN2_HUMAN (30-455): 2.08e-26: 117: 15.30
+	Mm
		610633 CBL_MOUSE (1-906): 0: 888: 91.59		NCK1_MOUSE (104-421): 1.23e-32: 131: 15.93
+	Hs
		610415 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Mm
		610598 CBL_MOUSE (1-906): 0: 888: 91.59		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		275173 CBL_HUMAN (1-906): 0: 917: 100.00		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		610407 CBL_HUMAN (1-906): 0: 917: 100.00		ARHG6_HUMAN (218-345): 4.37e-16: 84.3: 24.81
+	Hs
		208994 CBL_HUMAN (1-906): 0: 917: 100.00		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		235473 CBL_HUMAN (1-906): 0: 917: 100.00		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Hs
		610397 CBL_HUMAN (1-906): 0: 917: 100.00		ARHG7_HUMAN (228-354): 4.83e-14: 77.8: 20.31
+	Hs
		548639 CBL_HUMAN (1-906): 0: 917: 100.00		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		298949 CBL_HUMAN (1-906): 0: 917: 100.00		SRBS2_HUMAN (3-155): 4.65e-11: 68.2: 30.86
+	Mm
		292681 CBL_MOUSE (1-906): 0: 888: 91.59		GRAP2_MOUSE (1-55): 2.15e-16: 82.8: 30.91
+	Mm
		610608 CBL_MOUSE (1-906): 0: 888: 91.59		SRBS1_MOUSE (3-155): 1.1e-13: 77: 34.15
+	Mm
		610595 CBL_MOUSE (1-906): 0: 888: 91.59		SRBS2_MOUSE (3-155): 3.32e-11: 68.9: 30.86