Protein: TBD2B
TBC1 domain family member 2B

Gene: TBD2B, TBC1D2B
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q9UPU7

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1454401

PAK5
Serine/threonine-protein kinase PAK 5

2

14

High-throughput

0.811

High

976670

RB11A
Ras-related protein Rab-11A

2

20

High-throughput

0.754

High

249018

EVI5
Ecotropic viral integration site 5 protein homolog

1

12

High-throughput

0.691

High

945536

SNX16
Sorting nexin-16

1

3

High-throughput

0.691

High

1104895

SNTB2
Beta-2-syntrophin

1

11

High-throughput

0.691

High

1116139

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

9

High-throughput

0.691

High

610511

PRS6A
26S proteasome regulatory subunit 6A

4

12

High-throughput

0.691

High

1369646

APBB2
Amyloid beta precursor protein binding family B member 2

4

2

High-throughput

0.691

High

1430367

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

20

Small-scale

0.655

High

941379

CAV3
Caveolin-3

2

2

High-throughput

0.628

High

1180416

KLH40
Kelch-like protein 40

2

2

High-throughput

0.628

High

1390073

PTCD3
Small ribosomal subunit protein mS39

2

1

High-throughput

0.628

High

631566

RAB5A
Ras-related protein Rab-5A

1

20

High-throughput

0.618

High

910256

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

945122

RAB25
Ras-related protein Rab-25

1

20

High-throughput

0.618

High

953762

RAC3
Ras-related C3 botulinum toxin substrate 3

1

19

High-throughput

0.618

High

978409

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

988832

RAC1
Ras-related C3 botulinum toxin substrate 1

1

19

High-throughput

0.618

High

1015909

RHOG
Rho-related GTP-binding protein RhoG

1

17

High-throughput

0.618

High

1141047

KIF14
Kinesin-like protein KIF14

1

15

High-throughput

0.618

High

1145177

RAB35
Ras-related protein Rab-35

1

20

High-throughput

0.618

High

1227718

A16L1
Autophagy-related protein 16-1

1

15

High-throughput

0.618

High

1366916

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1391860

AURKB
Aurora kinase B

1

11

High-throughput

0.618

High

1436560

ECT2
Protein ECT2

1

8

High-throughput

0.618

High

1462589

WASC3
WASH complex subunit 3

3

1

High-throughput

0.604

High

488268

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.602

High

1397261

LURA1
Leucine rich adaptor protein 1

2

0

High-throughput

0.576

High

231653

PRKY
Putative serine/threonine-protein kinase PRKY

1

9

High-throughput

0.575

High

1211467

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.574

High

952384

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.569

High

1428426

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

High-throughput

0.569

High

1433244

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

Small-scale

0.561

High

631025

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.553

High

161679

TRDMT
tRNA

1

1

High-throughput

0.541

High

158518

RFXK
DNA-binding protein RFXANK

1

5

High-throughput

0.536

High

295656

CIB2
Calcium and integrin-binding family member 2

1

9

High-throughput

0.536

High

296848

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.536

High

359888

DYR
Dihydrofolate reductase

1

2

High-throughput

0.536

High

549713

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

5

High-throughput

0.536

High

1205774

EFMT2
EEF1A lysine methyltransferase 2

1

1

High-throughput

0.536

High

1207281

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

1

High-throughput

0.536

High

1331582

CE120
Centrosomal protein of 120 kDa

1

14

High-throughput

0.536

High

1383891

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

1412923

NAA11
N-alpha-acetyltransferase 11

1

2

High-throughput

0.536

High

1420262

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

1434772

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

1451559

ASB6
Ankyrin repeat and SOCS box protein 6

1

3

High-throughput

0.536

High

1460793

HSPB8
Heat shock protein beta-8

1

3

High-throughput

0.536

High

1462434

TFR2
Transferrin receptor protein 2

1

1

High-throughput

0.536

High

328194

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.527

High

1417424

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

20

High-throughput

0.527

High

636905

GSTM3
Glutathione S-transferase Mu 3

1

0

High-throughput

0.513

High

1349620

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

0

High-throughput

0.513

High

1357230

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

445289

S10A6
Protein S100-A6

1

0

High-throughput

0.493

High

74646

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

9

High-throughput

0.489

High

186352

RA51B
DNA repair protein RAD51 homolog 2

1

2

High-throughput

0.489

High

1177127

INF2
Inverted formin-2

1

4

High-throughput

0.489

High

1325859

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

1402741

TCPQM
T-complex protein 1 subunit theta-like 2

1

6

High-throughput

0.489

High

1407020

NPAS1
Neuronal PAS domain-containing protein 1

1

1

High-throughput

0.489

High

1436858

SYP2L
Synaptopodin 2-like protein

1

6

High-throughput

0.489

High

1462590

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.489

High

173560

XPO1
Exportin-1

1

17

High-throughput

0.479

High

294534

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

323612

TRI37
E3 ubiquitin-protein ligase TRIM37

1

15

High-throughput

0.479

High

437394

K2C8
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

459807

PROF1
Profilin-1

1

3

High-throughput

0.479

High

604276

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

896668

VASP
Vasodilator-stimulated phosphoprotein

1

3

High-throughput

0.479

High

984333

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

8

High-throughput

0.479

High

1156623

CCDC6
Coiled-coil domain-containing protein 6

1

15

High-throughput

0.479

High

1233582

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1365396

CNOT9
CCR4-NOT transcription complex subunit 9

1

1

High-throughput

0.479

High

1371991

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

1

High-throughput

0.479

High

1383714

VP33A
Vacuolar protein sorting-associated protein 33A

1

6

High-throughput

0.479

High

1403092

CEP89
Centrosomal protein of 89 kDa

1

13

High-throughput

0.479

High

1411379

LZTS2
Leucine zipper putative tumor suppressor 2

1

14

High-throughput

0.479

High

290206

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

1338439

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1385722

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.458

High

1451933

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.458

High

827967

STAT3
Signal transducer and activator of transcription 3

1

4

High-throughput

0.445

High

1239341

ARMC6
Armadillo repeat-containing protein 6

1

2

High-throughput

0.445

High

888491

TSP3
Thrombospondin-3

1

2

High-throughput

0.437

High

1241988

FBX42
F-box only protein 42

1

5

High-throughput

0.437

High

1451645

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

2

High-throughput

0.437

High

1167131

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

1

High-throughput

0.407

High

1454130

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

4

High-throughput

0.407

High

1462588

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.328

High

690061

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.279

Low

1178917

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1316015

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1398213

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.279

Low

1412907

PHAF1
Phagosome assembly factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025