HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SLAP2 (Q9H6Q3)
Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2)
Gene: SLA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.753

Property	Details
Experiments	11891219, 33620036, 17353186, 11696592, 16623714, 12527895, 33617900
Identification Methods	affinity chromatography technology, biochemical, pull down, x-ray crystallography, enzymatic study
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 261
+	Hs
		412013 CBL_HUMAN (1-906): 0: 917: 100.00		FYN_HUMAN (6-259): 1.62e-81: 255: 31.68
+	Hs
		442780 CBL_HUMAN (1-906): 0: 917: 100.00		HCK_HUMAN (7-259): 4.34e-81: 254: 30.39
+	Hs
		433577 CBL_HUMAN (1-906): 0: 917: 100.00		LYN_HUMAN (6-257): 7.42e-80: 251: 31.27
+	Hs
		454799 CBL_HUMAN (1-906): 0: 917: 100.00		FGR_HUMAN (6-259): 4.1e-79: 249: 30.92
+	Hs
		433254 CBL_HUMAN (1-906): 0: 917: 100.00		YES_HUMAN (33-259): 1.87e-78: 248: 32.34
+	Hs
		411595 CBL_HUMAN (1-906): 0: 917: 100.00		LCK_HUMAN (2-259): 1.98e-78: 247: 30.57
+	Hs
		522778 CBL_HUMAN (1-906): 0: 917: 100.00		SRC_HUMAN (13-259): 9.05e-77: 243: 31.37
+	Hs
		610303 CBL_HUMAN (1-906): 0: 917: 100.00		BLK_HUMAN (2-259): 4.45e-77: 243: 30.88
+	Hs
		610368 CBL_HUMAN (1-906): 0: 917: 100.00		BTK_HUMAN (10-260): 1.44e-64: 214: 21.46
+	Hs
		610373 CBL_HUMAN (1-906): 0: 917: 100.00		ITK_HUMAN (8-260): 7.03e-64: 211: 22.56
+	Hs
		337348 CBL_HUMAN (1-906): 0: 917: 100.00		ABL1_HUMAN (2-260): 1.1e-59: 205: 23.60
+	Hs
		610281 CBL_HUMAN (1-906): 0: 917: 100.00		ABL2_HUMAN (11-260): 3.92e-58: 201: 22.09
+	Hs
		69201 CBL_HUMAN (1-906): 0: 917: 100.00		A9UF07_HUMAN (2-260): 5.23e-58: 201: 23.22
+	Hs
		610276 CBL_HUMAN (1-906): 0: 917: 100.00		CSK_HUMAN (18-240): 5.46e-60: 198: 27.54
+	Hs
		610386 CBL_HUMAN (1-906): 0: 917: 100.00		SLAP1_HUMAN (13-259): 4.83e-60: 193: 38.49
+	Mm
		337618 CBL_MOUSE (1-906): 0: 888: 91.59		ABL1_MOUSE (2-260): 1.91e-59: 204: 23.22
+	Hs
		275173 CBL_HUMAN (1-906): 0: 917: 100.00		GRAP2_HUMAN (37-176): 3.39e-15: 75.9: 37.14
+	Hs
		610338 CBL_HUMAN (1-906): 0: 917: 100.00		GRB2_HUMAN (37-176): 3.68e-13: 68.6: 32.39
+	Hs
		610437 CBL_HUMAN (1-906): 0: 917: 100.00		Q6ICN0_HUMAN (37-176): 3.76e-13: 68.6: 32.39
+	Mm
		292681 CBL_MOUSE (1-906): 0: 888: 91.59		GRAP2_MOUSE (37-176): 1.25e-13: 71.2: 35.71