HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	22558309
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 1697
+	Mm
		610657 CBL_MOUSE (1-906): 0: 888: 91.59		ITSN2_MOUSE (1-1697): 0: 904: 88.92
+	Hs
		610415 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1027627 CBLB_HUMAN (23-901): 0: 793: 46.65		ITSN2_HUMAN (1-1697): 0: 969: 100.00
+	Mm
		610656 CBL_MOUSE (1-906): 0: 888: 91.59		ITSN1_MOUSE (2-1693): 0: 861: 56.37
+	Mm
		1112081 CBLB_MOUSE (23-901): 0: 791: 45.98		ITSN2_MOUSE (1-1697): 0: 904: 88.92
+	Hs
		1027606 CBLB_HUMAN (23-901): 0: 793: 46.65		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		610520 CBL_HUMAN (1-906): 0: 917: 100.00		EP15R_HUMAN (3-509): 1.83e-36: 152: 16.67
+	Hs
		1027629 CBLB_HUMAN (23-901): 0: 793: 46.65		VAV3_HUMAN (1119-1589): 1.73e-66: 245: 15.37
+	Hs
		610518 CBL_HUMAN (1-906): 0: 917: 100.00		ARHGC_HUMAN (1189-1535): 2.93e-21: 103: 27.07
+	Hs
		548639 CBL_HUMAN (1-906): 0: 917: 100.00		VAV_HUMAN (526-1189): 1.23e-13: 78.3: 13.15
+	Hs
		610397 CBL_HUMAN (1-906): 0: 917: 100.00		ARHG7_HUMAN (770-1003): 4.21e-12: 73.3: 18.14
+	Hs
		610308 CBL_HUMAN (1-906): 0: 917: 100.00		VAV2_HUMAN (614-1182): 8.45e-12: 72.6: 12.07
+	Hs
		610407 CBL_HUMAN (1-906): 0: 917: 100.00		ARHG6_HUMAN (878-973): 2.21e-11: 71: 23.71
+	Mm
		610601 CBL_MOUSE (1-906): 0: 888: 91.59		EP15R_MOUSE (13-132): 1.69e-16: 87.7: 27.87
+	Dm
		112567 O46034_DROME (47-460): 0: 746: 70.84		M9ND00_DROME (1-447): 2.52e-32: 139: 14.35
+	Mm
		1112055 CBLB_MOUSE (23-901): 0: 791: 45.98		EP15R_MOUSE (13-132): 1.69e-16: 87.7: 27.87
+	Hs
		548699 CBLB_HUMAN (23-901): 0: 793: 46.65		VAV_HUMAN (526-1189): 1.23e-13: 78.3: 13.15
+	Mm
		82736 B9EKI5_MOUSE (23-901): 0: 799: 47.22		VAV2_MOUSE (614-1182): 1.63e-11: 71.4: 13.29
+	Hs
		1027604 CBLB_HUMAN (23-901): 0: 793: 46.65		ARHG7_HUMAN (770-1003): 4.21e-12: 73.3: 18.14
+	Hs
		855791 CBLB_HUMAN (23-901): 0: 793: 46.65		VAV2_HUMAN (614-1182): 8.45e-12: 72.6: 12.07