HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: EGFR (Q01279)
Epidermal growth factor receptor (EC 2.7.10.1)
Gene: EGFR

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 0.60 0.741

The method score is based on:

Property Details
Experiments 17372273, 17139251, 23457600, 7657591, 23027125, 14691459, 20298671, 23799367
Identification Methods affinity chromatography technology, unspecified method, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007166 - cell surface receptor signaling pathway
GO:0019901 - protein kinase binding
GO:0042059 - negative regulation of epidermal growth factor receptor signaling pathway
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 913
Mm

1 1210
+ Rn
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024