Protein: ACK1
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)

Gene: ACK1, TNK2
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q07912

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005095 - GTPase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987579

GRB2
Growth factor receptor-bound protein 2

12

20

Small-scale

0.981

High

955093

CDC42
Cell division control protein 42 homolog

12

20

Small-scale

0.980

High

363177

EGFR
Epidermal growth factor receptor

8

20

Small-scale

0.956

High

1060768

ACK1
Activated CDC42 kinase 1

6

20

Small-scale

0.948

High

461399

HS90A
Heat shock protein HSP 90-alpha

6

20

Small-scale

0.928

High

557254

SRC
Proto-oncogene tyrosine-protein kinase Src

5

20

Small-scale

0.926

High

593976

NCK1
SH2/SH3 adapter protein NCK1

5

20

Small-scale

0.924

High

222066

NCK2
Cytoplasmic protein NCK2

5

20

High-throughput

0.919

High

1060781

CDC37
Hsp90 co-chaperone Cdc37

5

20

Small-scale

0.919

High

468298

HS90B
Heat shock protein HSP 90-beta

4

20

Small-scale

0.867

High

1060817

SNX9
Sorting nexin-9

3

16

Small-scale

0.866

High

1060800

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

3

20

Small-scale

0.864

High

1060803

HSH2D
Hematopoietic SH2 domain-containing protein

3

20

Small-scale

0.861

High

258594

SH21A
SH2 domain-containing protein 1A

2

19

High-throughput

0.845

High

484116

PGFRB
Platelet-derived growth factor receptor beta

2

20

Small-scale

0.819

High

425467

ISG15
Ubiquitin-like protein ISG15

2

15

High-throughput

0.811

High

184286

NPHP1
Nephrocystin-1

2

1

Small-scale

0.807

High

728195

AKT1
RAC-alpha serine/threonine-protein kinase

2

20

Small-scale

0.806

High

942578

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

20

Small-scale

0.789

High

164856

SH21B
SH2 domain-containing protein 1B

2

20

High-throughput

0.783

High

463070

YES
Tyrosine-protein kinase Yes

2

19

Small-scale

0.778

High

473406

HCK
Tyrosine-protein kinase HCK

2

19

Small-scale

0.778

High

699714

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.740

High

1060809

NEK6
Serine/threonine-protein kinase Nek6

1

20

High-throughput

0.740

High

1025997

CLH1
Clathrin heavy chain 1

6

8

Small-scale

0.729

High

440513

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.724

High

463478

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.724

High

541448

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.724

High

1060778

SRC8
Src substrate cortactin

1

20

Small-scale

0.724

High

1060786

H90B3
Putative heat shock protein HSP 90-beta-3

2

20

High-throughput

0.712

High

171696

GAK
Cyclin-G-associated kinase

1

20

High-throughput

0.691

High

176820

DCLK1
Serine/threonine-protein kinase DCLK1

1

18

High-throughput

0.691

High

1060799

SOCS4
Suppressor of cytokine signaling 4

2

20

High-throughput

0.686

High

711875

LTK
Leukocyte tyrosine kinase receptor

1

20

Small-scale

0.665

High

720201

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.665

High

507875

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

14

Small-scale

0.647

High

1060773

PAK2
Serine/threonine-protein kinase PAK 2

1

20

Small-scale

0.647

High

519979

ANDR
Androgen receptor

2

20

Small-scale

0.634

High

861583

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

20

Small-scale

0.634

High

424862

ADT2
ADP/ATP translocase 2

3

6

Small-scale

0.633

High

842643

WASP
Actin nucleation-promoting factor WAS

2

20

Small-scale

0.629

High

462152

GALT
Galactose-1-phosphate uridylyltransferase

2

0

High-throughput

0.626

High

1060804

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

20

Small-scale

0.624

High

1060797

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

11

Small-scale

0.619

High

347664

BAG3
BAG family molecular chaperone regulator 3

2

6

Small-scale

0.619

High

138485

BIN1
Myc box-dependent-interacting protein 1

1

20

Small-scale

0.618

High

411803

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.618

High

834181

CSK
Tyrosine-protein kinase CSK

1

20

Small-scale

0.618

High

838075

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

20

Small-scale

0.618

High

855600

CRK
Adapter molecule crk

1

20

Small-scale

0.618

High

855857

CRKL
Crk-like protein

1

20

Small-scale

0.618

High

966235

1433G
14-3-3 protein gamma

1

20

High-throughput

0.618

High

990140

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.618

High

1060770

MERTK
Tyrosine-protein kinase Mer

1

19

Small-scale

0.618

High

1060772

LCP2
Lymphocyte cytosolic protein 2

1

20

Small-scale

0.618

High

1060780

NTRK3
NT-3 growth factor receptor

1

20

Small-scale

0.618

High

1060782

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.618

High

1060814

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.618

High

1060812

WWOX
WW domain-containing oxidoreductase

2

1

Small-scale

0.595

High

1060805

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

2

0

High-throughput

0.580

High

471740

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

High-throughput

0.575

High

1050783

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.575

High

1060771

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

20

High-throughput

0.575

High

1060787

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

715888

AQP1
Aquaporin-1

1

1

High-throughput

0.573

High

1060794

NT2NA
Notch homolog 2 N-terminal-like protein A

1

20

High-throughput

0.573

High

532540

CH60
60 kDa heat shock protein, mitochondrial

2

10

High-throughput

0.571

High

610632

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.571

High

821319

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.571

High

875928

TCPE
T-complex protein 1 subunit epsilon

2

20

High-throughput

0.571

High

881888

TCPG
T-complex protein 1 subunit gamma

2

20

High-throughput

0.571

High

882643

EFTU
Elongation factor Tu, mitochondrial

2

2

High-throughput

0.571

High

899005

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.571

High

899358

TCPD
T-complex protein 1 subunit delta

2

20

High-throughput

0.571

High

1006988

TCPB
T-complex protein 1 subunit beta

2

20

High-throughput

0.571

High

680328

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

6

Small-scale

0.561

High

70181

CRTP1
Cysteine-rich tail protein 1

2

2

High-throughput

0.553

High

648816

KCNA5
Potassium voltage-gated channel subfamily A member 5

1

15

Small-scale

0.536

High

211778

ZW10
Centromere/kinetochore protein zw10 homolog

1

2

High-throughput

0.536

High

669879

MCM3
DNA replication licensing factor MCM3

1

9

High-throughput

0.536

High

1060775

MTA1
Metastasis-associated protein MTA1

1

2

High-throughput

0.536

High

1060783

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

2

High-throughput

0.536

High

1060806

NUF2
Kinetochore protein Nuf2

1

20

High-throughput

0.536

High

1060811

GTSE1
G2 and S phase-expressed protein 1

1

1

High-throughput

0.536

High

1060815

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.513

High

131985

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.501

High

1060788

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

20

Small-scale

0.501

High

1060792

HECW1
E3 ubiquitin-protein ligase HECW1

1

20

Small-scale

0.501

High

1060810

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

20

Small-scale

0.501

High

949860

KR103
Keratin-associated protein 10-3

1

10

High-throughput

0.481

High

186737

P73
Tumor protein p73

1

12

Small-scale

0.479

High

211561

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

18

Small-scale

0.479

High

273663

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

13

High-throughput

0.479

High

413700

P53
Cellular tumor antigen p53

1

12

Small-scale

0.479

High

483078

CLCA
Clathrin light chain A

1

2

Small-scale

0.479

High

533819

MCF2
Proto-oncogene DBL

1

20

Small-scale

0.479

High

578617

FABP4
Fatty acid-binding protein, adipocyte

1

3

Small-scale

0.479

High

801282

HSPA9
Stress-70 protein, mitochondrial

1

20

Small-scale

0.479

High

857319

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

7

Small-scale

0.479

High

883042

AMPH
Amphiphysin

1

18

Small-scale

0.479

High

991015

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

3

High-throughput

0.479

High

1051358

ZBT16
Zinc finger and BTB domain-containing protein 16

1

5

Small-scale

0.479

High

1060769

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

1060776

SQSTM
Sequestosome-1

1

7

Small-scale

0.479

High

1060777

CUL3
Cullin-3

1

11

High-throughput

0.479

High

1060779

PDK1
[Pyruvate dehydrogenase

1

4

Small-scale

0.479

High

1060789

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

3

High-throughput

0.479

High

1060790

A16L1
Autophagy-related protein 16-1

1

18

Small-scale

0.479

High

1060793

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

1060796

TRI50
E3 ubiquitin-protein ligase TRIM50

1

16

Small-scale

0.479

High

1060801

KAT5
Histone acetyltransferase KAT5

1

2

Small-scale

0.479

High

1060808

KAT8
Histone acetyltransferase KAT8

1

2

Small-scale

0.479

High

1060816

KDM3A
Lysine-specific demethylase 3A

1

5

Small-scale

0.479

High

124319

HAX1
HCLS1-associated protein X-1

1

0

Small-scale

0.458

High

907236

ARSL
Arylsulfatase L

1

3

High-throughput

0.457

High

1037466

RL18A
Large ribosomal subunit protein eL20

1

1

High-throughput

0.457

High

1060774

SRSF5
Serine/arginine-rich splicing factor 5

1

4

High-throughput

0.457

High

1060784

SEZ6
Seizure protein 6 homolog

1

12

High-throughput

0.457

High

1060798

RGF1C
Ras-GEF domain-containing family member 1C

1

20

High-throughput

0.457

High

1033965

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

20

High-throughput

0.445

High

1060785

KLH22
Kelch-like protein 22

1

3

High-throughput

0.445

High

1060802

ITFG2
KICSTOR complex protein ITFG2

1

0

High-throughput

0.438

High

1060813

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.438

High

1060807

TMX1
Thioredoxin-related transmembrane protein 1

1

12

High-throughput

0.437

High

1060791

ATL4
ADAMTS-like protein 4

1

4

High-throughput

0.417

High

1060795

RM55
Large ribosomal subunit protein mL55

2

0

High-throughput

0.298

High

939779

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025