Protein: JAK3
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)

Gene: JAK3
Organism: Homo sapiens
Interactions: 128
UniProt ID: P52333

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0002731 - negative regulation of dendritic cell cytokine production
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005131 - growth hormone receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

193237

SOCS1
Suppressor of cytokine signaling 1

4

20

Small-scale

0.851

High

658664

JAK1
Tyrosine-protein kinase JAK1

2

19

Small-scale

0.789

High

911902

JAK3
Tyrosine-protein kinase JAK3

3

19

Small-scale

0.789

High

549102

CDK4
Cyclin-dependent kinase 4

2

20

High-throughput

0.789

High

838348

STA5A
Signal transducer and activator of transcription 5A

2

20

Small-scale

0.757

High

599178

IL7RA
Interleukin-7 receptor subunit alpha

2

4

Small-scale

0.754

High

772476

IRS1
Insulin receptor substrate 1

2

20

Small-scale

0.754

High

911958

ALK
ALK tyrosine kinase receptor

2

20

Small-scale

0.754

High

728668

IL2RG
Cytokine receptor common subunit gamma

5

18

Small-scale

0.699

High

443275

CDK1
Cyclin-dependent kinase 1

1

17

High-throughput

0.698

High

136343

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.691

High

461296

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

468205

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.691

High

521258

ARAF
Serine/threonine-protein kinase A-Raf

1

20

High-throughput

0.691

High

871466

LEPR
Leptin receptor

1

20

Small-scale

0.691

High

885729

KC1E
Casein kinase I isoform epsilon

1

18

High-throughput

0.691

High

911903

DGKE
Diacylglycerol kinase epsilon

1

15

High-throughput

0.691

High

911918

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

20

High-throughput

0.691

High

911920

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.691

High

155926

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.665

High

253329

JAK2
Tyrosine-protein kinase JAK2

1

19

Small-scale

0.665

High

714596

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

18

Small-scale

0.665

High

827715

STAT3
Signal transducer and activator of transcription 3

1

20

Small-scale

0.665

High

838222

STAT6
Signal transducer and activator of transcription 6

1

20

Small-scale

0.665

High

911960

MAGD2
Melanoma-associated antigen D2

3

12

High-throughput

0.662

High

532065

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.647

High

641534

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

911925

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.647

High

325743

UBR5
E3 ubiquitin-protein ligase UBR5

2

20

High-throughput

0.628

High

610584

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.628

High

821271

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.628

High

898960

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.628

High

899307

TCPD
T-complex protein 1 subunit delta

2

20

High-throughput

0.628

High

911959

CHIP
E3 ubiquitin-protein ligase CHIP

2

16

High-throughput

0.628

High

907259

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.621

High

270787

ROCK2
Rho-associated protein kinase 2

1

20

Small-scale

0.618

High

296465

STAM2
Signal transducing adapter molecule 2

1

20

Small-scale

0.618

High

578425

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.618

High

911909

RB11A
Ras-related protein Rab-11A

1

10

High-throughput

0.618

High

911915

RON
Macrophage-stimulating protein receptor

1

19

High-throughput

0.618

High

911921

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

911941

STAM1
Signal transducing adapter molecule 1

1

20

Small-scale

0.618

High

911910

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

2

8

High-throughput

0.611

High

575820

IL2RB
Interleukin-2 receptor subunit beta

2

20

Small-scale

0.584

High

911926

RB11B
Ras-related protein Rab-11B

1

15

High-throughput

0.575

High

911931

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.575

High

911904

NP1L1
Nucleosome assembly protein 1-like 1

2

4

High-throughput

0.574

High

911950

NP1L4
Nucleosome assembly protein 1-like 4

2

4

High-throughput

0.574

High

635839

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

9

Small-scale

0.561

High

911946

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

9

Small-scale

0.561

High

911967

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.561

High

911932

GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

2

8

High-throughput

0.552

High

911938

LNX1
E3 ubiquitin-protein ligase LNX

2

20

High-throughput

0.542

High

165023

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

5

High-throughput

0.536

High

238875

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

4

High-throughput

0.536

High

261136

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.536

High

321472

PRP6
Pre-mRNA-processing factor 6

1

5

High-throughput

0.536

High

346915

BAG2
BAG family molecular chaperone regulator 2

1

6

High-throughput

0.536

High

402885

ANXA1
Annexin A1

1

8

High-throughput

0.536

High

480469

VILI
Villin-1

1

11

Small-scale

0.536

High

531024

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

20

High-throughput

0.536

High

559913

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.536

High

605978

CAN2
Calpain-2 catalytic subunit

1

1

High-throughput

0.536

High

731948

I5P2
Type II inositol 1,4,5-trisphosphate 5-phosphatase

1

20

High-throughput

0.536

High

786034

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.536

High

881838

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

911908

DCAF7
DDB1- and CUL4-associated factor 7

1

5

High-throughput

0.536

High

911911

TBA4A
Tubulin alpha-4A chain

1

20

High-throughput

0.536

High

911914

CENPC
Centromere protein C

1

4

High-throughput

0.536

High

911922

TEBP
Prostaglandin E synthase 3

1

5

High-throughput

0.536

High

911923

RNPS1
RNA-binding protein with serine-rich domain 1

1

5

High-throughput

0.536

High

911929

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

1

High-throughput

0.536

High

911933

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

1

18

High-throughput

0.536

High

911934

LARP4
La-related protein 4

1

14

High-throughput

0.536

High

911935

RFIP2
Rab11 family-interacting protein 2

1

20

High-throughput

0.536

High

911937

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

4

High-throughput

0.536

High

911939

GEMI6
Gem-associated protein 6

1

1

High-throughput

0.536

High

911940

GCN1
Stalled ribosome sensor GCN1

1

18

High-throughput

0.536

High

911942

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

14

High-throughput

0.536

High

911945

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

11

High-throughput

0.536

High

911947

CCNL2
Cyclin-L2

1

5

High-throughput

0.536

High

911963

MYO5A
Unconventional myosin-Va

1

8

High-throughput

0.536

High

911965

TNPO3
Transportin-3

1

20

High-throughput

0.536

High

911966

MAGD1
Melanoma-associated antigen D1

1

12

High-throughput

0.536

High

155093

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.527

High

911955

CISH
Cytokine-inducible SH2-containing protein

1

20

Small-scale

0.527

High

665033

IL4RA
Interleukin-4 receptor subunit alpha

1

20

Small-scale

0.515

High

683218

TNR5
Tumor necrosis factor receptor superfamily member 5

1

20

Small-scale

0.515

High

911906

CXCR4
C-X-C chemokine receptor type 4

1

20

Small-scale

0.515

High

911917

NMI
N-myc-interactor

1

0

High-throughput

0.513

High

911924

MTFR1
Mitochondrial fission regulator 1

1

0

High-throughput

0.513

High

911949

METH
Methionine synthase

1

0

High-throughput

0.513

High

911951

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.513

High

911954

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

911956

RIC8B
Chaperone Ric-8B

1

0

High-throughput

0.513

High

162512

ANM5
Protein arginine N-methyltransferase 5

1

9

Small-scale

0.501

High

911913

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.494

High

158797

AP3D1
AP-3 complex subunit delta-1

1

18

High-throughput

0.489

High

184824

SPTC1
Serine palmitoyltransferase 1

1

3

High-throughput

0.489

High

723911

LCN1
Lipocalin-1

1

3

High-throughput

0.489

High

911930

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

5

High-throughput

0.489

High

911957

GPTC8
G patch domain-containing protein 8

1

11

High-throughput

0.489

High

911962

MTF2
Metal-response element-binding transcription factor 2

1

2

High-throughput

0.489

High

911964

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.489

High

911905

CD81
CD81 antigen

1

11

High-throughput

0.481

High

460251

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

5

Small-scale

0.479

High

639691

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.479

High

903288

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

12

High-throughput

0.479

High

911907

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.479

High

911912

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.479

High

911916

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

20

Small-scale

0.479

High

911919

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.479

High

911943

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

911944

OPTN
Optineurin

1

20

Small-scale

0.479

High

387251

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.460

High

340856

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

17

Small-scale

0.445

High

182258

WDR46
WD repeat-containing protein 46

1

9

High-throughput

0.437

High

911953

TBB1
Tubulin beta-1 chain

1

20

High-throughput

0.437

High

911961

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.437

High

3012

A0A0G2JJL1
WD repeat domain 46

1

3

High-throughput

0.407

High

114471

H0Y9L7
TATA-box binding protein associated factor 1

1

2

High-throughput

0.407

High

336249

TIAF1
Putative TGFB1-induced anti-apoptotic factor 1

1

0

Small-scale

0.288

High

911927

CRY1
Cryptochrome-1

1

0

High-throughput

0.279

Low

911928

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.279

Low

911936

LYSM2
LysM and putative peptidoglycan-binding domain-containing protein 2

1

0

High-throughput

0.279

Low

911948

LGMN
Legumain

1

0

High-throughput

0.279

Low

911952

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025