Protein: TYK2
Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)

Gene: TYK2
Organism: Homo sapiens
Interactions: 146
UniProt ID: P29597

Gene Ontology (top 5):
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005131 - growth hormone receptor binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

193213

SOCS1
Suppressor of cytokine signaling 1

3

20

Small-scale

0.814

High

623995

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

2

20

Small-scale

0.806

High

711035

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.806

High

714645

LRC46
Leucine-rich repeat-containing protein 46

4

20

High-throughput

0.797

High

714597

STAT2
Signal transducer and activator of transcription 2

2

20

Small-scale

0.789

High

602867

INAR1
Interferon alpha/beta receptor 1

13

20

Small-scale

0.759

High

584483

VAV
Proto-oncogene vav

2

20

Small-scale

0.754

High

714577

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

18

Small-scale

0.754

High

440395

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.724

High

463362

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.724

High

714602

HNRPK
Heterogeneous nuclear ribonucleoprotein K

4

20

High-throughput

0.705

High

714624

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

4

20

High-throughput

0.703

High

714618

FHL3
Four and a half LIM domains protein 3

4

20

High-throughput

0.700

High

714603

RAN
GTP-binding nuclear protein Ran

1

12

High-throughput

0.691

High

220476

RNF13
E3 ubiquitin-protein ligase RNF13

3

11

High-throughput

0.667

High

714598

EFNB2
Ephrin-B2

3

7

High-throughput

0.667

High

468103

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.665

High

611002

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

Small-scale

0.665

High

714581

IL6RB
Interleukin-6 receptor subunit beta

1

20

Small-scale

0.665

High

714596

JAK3
Tyrosine-protein kinase JAK3

1

18

Small-scale

0.665

High

714612

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.665

High

714611

Q05BL1
TP53BP2 protein

1

20

High-throughput

0.665

High

714592

DYN2
Dynamin-2

1

19

High-throughput

0.656

High

714650

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.656

High

714585

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

20

Small-scale

0.647

High

714667

IRS2
Insulin receptor substrate 2

1

20

Small-scale

0.647

High

165792

TR13B
Tumor necrosis factor receptor superfamily member 13B

3

0

High-throughput

0.634

High

714644

IFT43
Intraflagellar transport protein 43 homolog

3

0

High-throughput

0.634

High

714604

RACK1
Small ribosomal subunit protein RACK1

2

12

Small-scale

0.631

High

549735

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

1

High-throughput

0.628

High

665027

IL4RA
Interleukin-4 receptor subunit alpha

2

20

High-throughput

0.628

High

714599

CADH8
Cadherin-8

2

20

High-throughput

0.628

High

714635

GP156
Probable G-protein coupled receptor 156

2

8

High-throughput

0.628

High

714638

HAVR2
Hepatitis A virus cellular receptor 2

2

4

High-throughput

0.628

High

714655

TNR19
Tumor necrosis factor receptor superfamily member 19

2

2

High-throughput

0.628

High

714616

ASPP2
Apoptosis-stimulating of p53 protein 2

1

20

High-throughput

0.621

High

714660

OPT
Opticin

1

20

High-throughput

0.618

High

155081

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.618

High

253305

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

296447

STAM2
Signal transducing adapter molecule 2

1

20

Small-scale

0.618

High

461182

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

533834

GHR
Growth hormone receptor

1

20

Small-scale

0.618

High

603177

KPCA
Protein kinase C alpha type

1

20

Small-scale

0.618

High

614656

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

20

High-throughput

0.618

High

658635

JAK1
Tyrosine-protein kinase JAK1

1

19

Small-scale

0.618

High

714580

TGFR2
TGF-beta receptor type-2

1

20

High-throughput

0.618

High

714586

STA5A
Signal transducer and activator of transcription 5A

1

20

Small-scale

0.618

High

714588

CRKL
Crk-like protein

1

20

Small-scale

0.618

High

714595

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.618

High

714632

AHI1
Jouberin

1

20

Small-scale

0.618

High

714652

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

20

High-throughput

0.618

High

70127

CRTP1
Cysteine-rich tail protein 1

2

3

High-throughput

0.606

High

284651

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

2

20

High-throughput

0.606

High

714620

K1H1
Keratin, type I cuticular Ha1

2

12

High-throughput

0.606

High

714654

PRDM5
PR domain zinc finger protein 5

2

3

High-throughput

0.606

High

284287

GEMI
Geminin

2

0

High-throughput

0.602

High

714584

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.602

High

714631

DAAF8
Dynein axonemal assembly factor 8

2

0

High-throughput

0.602

High

669257

PTAFR
Platelet-activating factor receptor

2

20

Small-scale

0.601

High

578392

BRAF
Serine/threonine-protein kinase B-raf

1

20

Small-scale

0.575

High

714600

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

20

High-throughput

0.575

High

714609

KPCE
Protein kinase C epsilon type

1

20

Small-scale

0.575

High

714625

K1C40
Keratin, type I cytoskeletal 40

1

11

High-throughput

0.573

High

714649

TRAF4
TNF receptor-associated factor 4

1

20

High-throughput

0.573

High

65016

GG6L9
Golgin subfamily A member 6-like protein 9

2

20

High-throughput

0.553

High

714607

I13R1
Interleukin-13 receptor subunit alpha-1

2

20

Small-scale

0.552

High

186244

SIVA
Apoptosis regulatory protein Siva

1

1

Small-scale

0.552

High

714641

CSN5
COP9 signalosome complex subunit 5

1

8

Small-scale

0.552

High

323966

CSTN1
Calsyntenin-1

1

20

High-throughput

0.536

High

346869

BAG2
BAG family molecular chaperone regulator 2

1

7

High-throughput

0.536

High

406869

MAS
Proto-oncogene Mas

1

20

High-throughput

0.536

High

415374

HSPB1
Heat shock protein beta-1

1

7

High-throughput

0.536

High

486542

TACD2
Tumor-associated calcium signal transducer 2

1

1

High-throughput

0.536

High

538526

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

4

High-throughput

0.536

High

608464

DDX5
Probable ATP-dependent RNA helicase DDX5

1

7

High-throughput

0.536

High

610539

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.536

High

714578

CD6
T-cell differentiation antigen CD6

1

6

High-throughput

0.536

High

714579

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

20

High-throughput

0.536

High

714582

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.536

High

714583

TPOR
Thrombopoietin receptor

1

7

High-throughput

0.536

High

714589

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.536

High

714591

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

714593

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

714594

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

714601

CXCR4
C-X-C chemokine receptor type 4

1

20

High-throughput

0.536

High

714605

TBA4A
Tubulin alpha-4A chain

1

15

High-throughput

0.536

High

714606

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.536

High

714613

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.536

High

714615

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.536

High

714637

WDR20
WD repeat-containing protein 20

1

16

High-throughput

0.536

High

714640

MADD
MAP kinase-activating death domain protein

1

15

High-throughput

0.536

High

714647

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

714659

NLGN3
Neuroligin-3

1

2

High-throughput

0.536

High

714663

TRAK1
Trafficking kinesin-binding protein 1

1

20

High-throughput

0.536

High

714664

RUVB2
RuvB-like 2

1

3

High-throughput

0.536

High

714665

RUVB1
RuvB-like 1

1

3

High-throughput

0.536

High

714666

C170B
Centrosomal protein of 170 kDa protein B

1

20

High-throughput

0.536

High

714610

UPAR
Urokinase plasminogen activator surface receptor

1

4

Small-scale

0.515

High

714661

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.515

High

714623

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

714634

TM130
Transmembrane protein 130

1

0

High-throughput

0.513

High

714643

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

162478

ANM5
Protein arginine N-methyltransferase 5

1

12

Small-scale

0.501

High

714621

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

714608

IDD
Integral membrane protein DGCR2/IDD

1

6

High-throughput

0.489

High

714622

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

5

High-throughput

0.489

High

714651

CSTN2
Calsyntenin-2

1

20

High-throughput

0.489

High

405404

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

159522

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.479

High

168497

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

4

Small-scale

0.479

High

174488

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.479

High

211535

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

20

Small-scale

0.479

High

342117

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

559230

XRCC5
X-ray repair cross-complementing protein 5

1

4

Small-scale

0.479

High

639673

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.479

High

651175

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

714587

LPAR6
Lysophosphatidic acid receptor 6

1

20

High-throughput

0.479

High

714614

KLF10
Krueppel-like factor 10

1

7

Small-scale

0.479

High

714617

PTC1
Protein patched homolog 1

1

1

Small-scale

0.479

High

714619

LRP8
Low-density lipoprotein receptor-related protein 8

1

4

High-throughput

0.479

High

714626

ELP2
Elongator complex protein 2

1

9

Small-scale

0.479

High

714628

THOC4
THO complex subunit 4

1

7

High-throughput

0.479

High

714633

MIER2
Mesoderm induction early response protein 2

1

4

High-throughput

0.479

High

714636

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.479

High

714646

ZN333
Zinc finger protein 333

1

4

High-throughput

0.479

High

714653

BRD7
Bromodomain-containing protein 7

1

17

High-throughput

0.479

High

714657

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

714658

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

10

High-throughput

0.479

High

353007

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.470

High

714642

UBE2F
NEDD8-conjugating enzyme UBE2F

1

4

High-throughput

0.457

High

457251

TBB5
Tubulin beta chain

1

12

High-throughput

0.445

High

616722

SDC1
Syndecan-1

1

5

High-throughput

0.445

High

714590

SL9A3
Sodium/hydrogen exchanger 3

1

2

High-throughput

0.445

High

714630

INLR1
Interferon lambda receptor 1

1

12

High-throughput

0.445

High

714639

MOT10
Monocarboxylate transporter 10

1

12

High-throughput

0.445

High

714656

S22AB
Solute carrier family 22 member 11

1

5

High-throughput

0.445

High

714662

MAGD2
Melanoma-associated antigen D2

1

11

High-throughput

0.445

High

50019

F170A
Protein FAM170A

1

0

High-throughput

0.426

High

351079

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.426

High

714648

CCM2
Cerebral cavernous malformations 2 protein

1

0

High-throughput

0.426

High

63745

KRBA1
Protein KRBA1

1

1

High-throughput

0.407

High

714627

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.328

High

66871

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

71196

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

714629

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025