HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: CRK (Q64010)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.60 0.752

The method score is based on:

Property Details
Experiments 15581361, 9013636, 15581362, 10633073, 11997497, 9447983, 20697350, 8635998, 11069064, 9210408, 27474268
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0017124 - SH3 domain binding
GO:0030971 - receptor tyrosine kinase binding
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 913
Mm

1 304
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Last updated: 15 Jul 2024