HitPredict

Interactor 1: JAK1 (P23458)
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)
Gene: JAK1

Interactor 2: I27RA (Q6UWB1)
Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
Gene: IL27RA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12734330
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1154 Hs			1 636
+	Hs
		616858 JAK1_HUMAN (1-1154): 0: 1035: 100.00		CSF3R_HUMAN (32-629): 4.81e-80: 272: 20.10
+	Hs
		616859 JAK1_HUMAN (1-1154): 0: 1035: 100.00		OSMR_HUMAN (36-630): 1.61e-73: 256: 16.35
+	Hs
		616753 JAK1_HUMAN (1-1154): 0: 1035: 100.00		IL6RB_HUMAN (2-316): 7.71e-14: 76.9: 11.04
+	Hs
		238434 JAK2_HUMAN (33-1153): 0: 799: 42.14		I12R2_HUMAN (32-635): 6.52e-81: 274: 21.20
+	Mm
		956337 JAK2_MOUSE (33-1153): 0: 778: 41.54		I12R2_MOUSE (20-609): 5.21e-78: 267: 19.78
+	Hs
		238382 JAK2_HUMAN (33-1153): 0: 799: 42.14		LEPR_HUMAN (50-412): 1.12e-20: 99.1: 18.28
+	Mm
		960491 JAK2_MOUSE (33-1153): 0: 778: 41.54		IL6RB_MOUSE (130-603): 6.83e-25: 112: 9.88
+	Mm
		817305 JAK2_MOUSE (33-1153): 0: 778: 41.54		LEPR_MOUSE (116-414): 2.26e-22: 104: 21.27
+	Hs
		238374 JAK2_HUMAN (33-1153): 0: 799: 42.14		IL6RB_HUMAN (2-316): 7.71e-14: 76.9: 11.04
+	Mm
		411919 LCK_MOUSE (833-1153): 6.52e-97: 319: 29.50		CSF3R_MOUSE (32-630): 6.73e-87: 290: 19.75
+	Hs
		442875 HCK_HUMAN (853-1152): 4.44e-92: 307: 31.56		CSF3R_HUMAN (32-629): 4.81e-80: 272: 20.10
+	Hs
		412016 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		PTPRD_HUMAN (21-629): 1.07e-63: 230: 12.07
+	Dm
		337644 ABL_DROME (868-1154): 1.63e-94: 334: 32.99		LAR_DROME (1-629): 8.62e-56: 207: 10.89
+	Hs
		411565 LCK_HUMAN (833-1153): 1.23e-96: 319: 30.44		PTPRF_HUMAN (25-631): 1.03e-51: 195: 11.58
+	Hs
		411959 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		PTPRF_HUMAN (25-631): 1.03e-51: 195: 11.58
+	Mm
		56907 FYN_MOUSE (843-1151): 8.15e-96: 318: 27.74		PTPRF_MOUSE (25-632): 3.71e-49: 187: 11.94
+	Hs
		433804 LYN_HUMAN (821-1152): 1.64e-90: 302: 28.23		SDK2_HUMAN (5-629): 1.11e-41: 165: 10.73
+	Hs
		362705 YES_HUMAN (868-1151): 1.52e-97: 322: 30.53		FINC_HUMAN (24-396): 8.68e-20: 96.5: 11.54
+	Hs
		362685 FYN_HUMAN (843-1151): 5.82e-96: 318: 27.74		FINC_HUMAN (24-396): 8.68e-20: 96.5: 11.54
+	Hs
		442787 HCK_HUMAN (853-1152): 4.44e-92: 307: 31.56		IL6RB_HUMAN (2-316): 7.71e-14: 76.9: 11.04