Protein: ZBTB1
Zinc finger and BTB domain-containing protein 1

Gene: ZBTB1
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q9Y2K1

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001817 - regulation of cytokine production
GO:0002682 - regulation of immune system process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

664402

ZBT25
Zinc finger and BTB domain-containing protein 25

3

18

High-throughput

0.861

High

1185346

F161A
Protein FAM161A

3

1

High-throughput

0.675

High

69847

ZN785
Zinc finger protein 785

3

20

High-throughput

0.662

High

783768

ZNF76
Zinc finger protein 76

2

18

High-throughput

0.628

High

1328776

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

3

High-throughput

0.625

High

1114699

CUL3
Cullin-3

1

20

High-throughput

0.618

High

1329018

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

17

Small-scale

0.618

High

1405714

NECD
Necdin

2

5

High-throughput

0.613

High

935657

MFAP1
Microfibrillar-associated protein 1

2

2

High-throughput

0.606

High

1371341

KAT5
Histone acetyltransferase KAT5

2

1

High-throughput

0.606

High

1416201

SCNM1
Sodium channel modifier 1

2

1

High-throughput

0.606

High

1339413

GP156
Probable G-protein coupled receptor 156

3

1

High-throughput

0.604

High

1239984

CAVN1
Caveolae-associated protein 1

2

0

High-throughput

0.602

High

1438639

GPBL1
Vasculin-like protein 1

2

0

High-throughput

0.602

High

920382

PLK1
Serine/threonine-protein kinase PLK1

2

3

High-throughput

0.584

High

541069

PIM1
Serine/threonine-protein kinase pim-1

1

2

High-throughput

0.573

High

1277136

ZN572
Zinc finger protein 572

1

17

High-throughput

0.573

High

1311486

TRI42
Tripartite motif-containing protein 42

1

20

High-throughput

0.573

High

1347750

ZN417
Zinc finger protein 417

1

18

High-throughput

0.573

High

1093997

TRAF1
TNF receptor-associated factor 1

1

8

High-throughput

0.560

High

977420

RS4X
Small ribosomal subunit protein eS4, X isoform

2

0

Small-scale

0.547

High

1033320

EWS
RNA-binding protein EWS

1

7

High-throughput

0.541

High

1395170

MAML3
Mastermind-like protein 3

1

2

High-throughput

0.541

High

185251

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.536

High

1128700

ZN460
Zinc finger protein 460

1

20

High-throughput

0.536

High

1360102

PALLD
Palladin

1

1

High-throughput

0.536

High

1435478

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

508862

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.501

High

551346

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.501

High

993822

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.501

High

657332

KALM
Anosmin-1

1

10

High-throughput

0.489

High

726709

SDC4
Syndecan-4

1

4

High-throughput

0.489

High

1124579

MAP7
Ensconsin

1

6

High-throughput

0.489

High

520471

ANDR
Androgen receptor

1

20

Small-scale

0.481

High

143340

NFIB
Nuclear factor 1 B-type

1

14

High-throughput

0.479

High

173581

XPO1
Exportin-1

1

12

High-throughput

0.479

High

247046

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.479

High

317046

MTA2
Metastasis-associated protein MTA2

1

2

Small-scale

0.479

High

345026

WIZ
Protein Wiz

1

20

Small-scale

0.479

High

397265

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

403043

ANXA1
Annexin A1

1

2

Small-scale

0.479

High

415948

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

429069

RLA0
Large ribosomal subunit protein uL10

1

4

Small-scale

0.479

High

457786

TBB5
Tubulin beta chain

1

1

Small-scale

0.479

High

474390

NFIC
Nuclear factor 1 C-type

1

15

High-throughput

0.479

High

476877

RSSA
Small ribosomal subunit protein uS2

1

5

Small-scale

0.479

High

485764

RU2A
U2 small nuclear ribonucleoprotein A'

1

1

Small-scale

0.479

High

502181

H2AZ
Histone H2A.Z

1

3

Small-scale

0.479

High

538148

HSP7C
Heat shock cognate 71 kDa protein

1

4

Small-scale

0.479

High

587842

DESP
Desmoplakin

1

4

Small-scale

0.479

High

595650

H15
Histone H1.5

1

15

Small-scale

0.479

High

620666

NUCL
Nucleolin

1

1

Small-scale

0.479

High

637800

FLNA
Filamin-A

1

2

Small-scale

0.479

High

761544

HS71L
Heat shock 70 kDa protein 1-like

1

4

Small-scale

0.479

High

776269

SOX6
Transcription factor SOX-6

1

8

High-throughput

0.479

High

799599

BRCA1
Breast cancer type 1 susceptibility protein

1

17

High-throughput

0.479

High

810467

RL3
Large ribosomal subunit protein uL3

1

7

Small-scale

0.479

High

824433

RL13A
Large ribosomal subunit protein uL13

1

5

Small-scale

0.479

High

859120

RL27A
Large ribosomal subunit protein uL15

1

2

Small-scale

0.479

High

860414

RS9
Small ribosomal subunit protein uS4

1

3

Small-scale

0.479

High

909742

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

1

Small-scale

0.479

High

953201

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.479

High

969526

RS8
Small ribosomal subunit protein eS8

1

2

Small-scale

0.479

High

970182

RS16
Small ribosomal subunit protein uS9

1

7

Small-scale

0.479

High

972618

RS14
Small ribosomal subunit protein uS11

1

1

Small-scale

0.479

High

973356

RS13
Small ribosomal subunit protein uS15

1

1

Small-scale

0.479

High

984593

RL30
Large ribosomal subunit protein eL30

1

3

Small-scale

0.479

High

985958

RL11
Large ribosomal subunit protein uL5

1

3

Small-scale

0.479

High

991272

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

1

Small-scale

0.479

High

997572

TBB4B
Tubulin beta-4B chain

1

1

Small-scale

0.479

High

1023200

RBM10
RNA-binding protein 10

1

1

Small-scale

0.479

High

1028458

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

High-throughput

0.479

High

1057966

RL18
Large ribosomal subunit protein eL18

1

1

Small-scale

0.479

High

1061214

SRSF1
Serine/arginine-rich splicing factor 1

1

14

Small-scale

0.479

High

1088112

NFIA
Nuclear factor 1 A-type

1

14

High-throughput

0.479

High

1100560

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.479

High

1110209

HDAC1
Histone deacetylase 1

1

3

High-throughput

0.479

High

1129792

MDC1
Mediator of DNA damage checkpoint protein 1

1

6

High-throughput

0.479

High

1133747

NFIX
Nuclear factor 1 X-type

1

14

High-throughput

0.479

High

1141071

KIF14
Kinesin-like protein KIF14

1

7

Small-scale

0.479

High

1144331

STK38
Serine/threonine-protein kinase 38

1

1

Small-scale

0.479

High

1149229

SF3A1
Splicing factor 3A subunit 1

1

1

Small-scale

0.479

High

1160130

SRSF7
Serine/arginine-rich splicing factor 7

1

8

Small-scale

0.479

High

1323196

CCAR2
Cell cycle and apoptosis regulator protein 2

1

3

Small-scale

0.479

High

1329957

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

1341051

THOC2
THO complex subunit 2

1

4

High-throughput

0.479

High

1363362

DDX1
ATP-dependent RNA helicase DDX1

1

1

Small-scale

0.479

High

1384488

PF21A
PHD finger protein 21A

1

16

High-throughput

0.479

High

1410410

MEP50
Methylosome protein WDR77

1

2

Small-scale

0.479

High

1417530

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1452578

BCLF1
Bcl-2-associated transcription factor 1

1

2

Small-scale

0.479

High

1458831

ZMYM2
Zinc finger MYM-type protein 2

1

2

High-throughput

0.479

High

1459368

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1461144

RCOR1
REST corepressor 1

1

2

High-throughput

0.479

High

1462504

TRI33
E3 ubiquitin-protein ligase TRIM33

1

20

Small-scale

0.479

High

1490794

MTCL1
Microtubule cross-linking factor 1

1

3

Small-scale

0.479

High

1417009

HEMGN
Hemogen

1

0

Small-scale

0.460

High

214986

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

0

Small-scale

0.458

High

552452

ADT3
ADP/ATP translocase 3

1

0

Small-scale

0.458

High

831677

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

840833

RS27
Small ribosomal subunit protein eS27

1

0

Small-scale

0.458

High

961443

RL27
Large ribosomal subunit protein eL27

1

0

Small-scale

0.458

High

964517

SUMO2
Small ubiquitin-related modifier 2

1

0

Small-scale

0.458

High

969730

RS15A
Small ribosomal subunit protein uS8

1

0

Small-scale

0.458

High

972798

RS23
Small ribosomal subunit protein uS12

1

0

Small-scale

0.458

High

973106

RS29
Small ribosomal subunit protein uS14

1

0

Small-scale

0.458

High

973632

RS11
Small ribosomal subunit protein uS17

1

0

Small-scale

0.458

High

974871

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

Small-scale

0.458

High

983090

RS25
Small ribosomal subunit protein eS25

1

0

Small-scale

0.458

High

986286

RL8
Large ribosomal subunit protein uL2

1

0

Small-scale

0.458

High

1064398

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

0

Small-scale

0.458

High

1098176

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.458

High

1118266

BLMH
Bleomycin hydrolase

1

0

Small-scale

0.458

High

1119542

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

1361042

P66B
Transcriptional repressor p66-beta

1

0

Small-scale

0.458

High

1402231

TESK2
Dual specificity testis-specific protein kinase 2

1

0

Small-scale

0.458

High

1007808

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.445

High

1094832

CAF1B
Chromatin assembly factor 1 subunit B

1

3

High-throughput

0.445

High

660758

IF4B
Eukaryotic translation initiation factor 4B

1

1

Small-scale

0.437

High

898893

RL14
Large ribosomal subunit protein eL14

1

4

Small-scale

0.437

High

996898

TBA1B
Tubulin alpha-1B chain

1

2

Small-scale

0.437

High

1024498

S25A3
Solute carrier family 25 member 3

1

1

Small-scale

0.437

High

1062319

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

3

Small-scale

0.437

High

1117534

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

3

Small-scale

0.437

High

1401826

PEO1
Twinkle mtDNA helicase

1

1

Small-scale

0.437

High

1458395

CRNN
Cornulin

1

7

Small-scale

0.437

High

1490795

O51B4
Olfactory receptor 51B4

1

1

Small-scale

0.437

High

1349000

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.426

High

616824

SDC1
Syndecan-1

1

4

High-throughput

0.407

High

760513

SDC2
Syndecan-2

1

4

High-throughput

0.407

High

1395433

NEUL4
Neuralized-like protein 4

1

1

High-throughput

0.407

High

1212113

TRML2
Trem-like transcript 2 protein

3

0

High-throughput

0.347

High

217295

ARK72
Aflatoxin B1 aldehyde reductase member 2

3

0

High-throughput

0.339

High

398014

KLKB1
Plasma kallikrein

2

0

High-throughput

0.328

High

1186448

ASTRB
Protein Aster-B

2

0

High-throughput

0.328

High

1326530

SPA6L
Spermatogenesis associated 6-like protein

2

0

High-throughput

0.318

High

1359141

PIHD2
PIH1 domain-containing protein 2

2

0

High-throughput

0.316

High

649778

SPR2E
Small proline-rich protein 2E

1

0

Small-scale

0.249

Low

829602

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

Small-scale

0.249

Low

880407

RL34
Large ribosomal subunit protein eL34

1

0

Small-scale

0.249

Low

912643

GDIR2
Rho GDP-dissociation inhibitor 2

1

0

Small-scale

0.249

Low

1013900

RL24
Large ribosomal subunit protein eL24

1

0

Small-scale

0.249

Low

1387805

MUCL1
Mucin-like protein 1

1

0

Small-scale

0.249

Low

1397896

CCD42
Coiled-coil domain-containing protein 42

1

0

Small-scale

0.249

Low

1410068

TRIR
Telomerase RNA component interacting RNase

1

0

Small-scale

0.249

Low

591399

CD44
CD44 antigen

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025