HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.817

The method score is based on:

Property Details
Experiments 8561895, 31839598, 11434923
Identification Methods affinity chromatography technology, cross-linking study, biochemical
Interaction Type physical association, dephosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains C2~C2, C2~PI-PLC-X, C2~PI-PLC-Y, C2~SH2, C2~SH3_1, PH~PH, PH~PI-PLC-X, PH~SH3_1, PI-PLC-X~PI-PLC-X, PI-PLC-X~PI-PLC-Y, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms GO:0001726 - ruffle
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0004435 - phosphatidylinositol-4,5-bisphosphate phospholipase C activity
GO:0004629 - phospholipase C activity
GO:0005085 - guanyl-nucleotide exchange factor activity
and 27 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 1290
Hs

1 1290
+ Bt
+ Rn
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025