Protein: PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)

Gene: PLCB1
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q9NQ66

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000785 - chromatin
GO:0004435 - phosphatidylinositol-4,5-bisphosphate phospholipase C activity
GO:0004629 - phospholipase C activity
GO:0005096 - GTPase activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

375983

RASK
GTPase KRas

3

20

High-throughput

0.827

High

893527

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

2

3

Small-scale

0.825

High

845483

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

2

High-throughput

0.667

High

669146

ARBK1
Beta-adrenergic receptor kinase 1

1

2

Small-scale

0.647

High

1446801

PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

1

5

Small-scale

0.647

High

374216

RASN
GTPase NRas

1

20

High-throughput

0.618

High

374949

RASH
GTPase HRas

1

19

High-throughput

0.618

High

716056

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

3

Small-scale

0.618

High

956507

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.618

High

978328

RHOB
Rho-related GTP-binding protein RhoB

1

17

High-throughput

0.618

High

1145126

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.618

High

1270288

BT2A1
Butyrophilin subfamily 2 member A1

3

3

High-throughput

0.609

High

162861

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

2

4

Small-scale

0.584

High

540695

LAMP1
Lysosome-associated membrane glycoprotein 1

2

2

High-throughput

0.584

High

1252605

DEFI8
Differentially expressed in FDCP 8 homolog

2

2

High-throughput

0.574

High

941575

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.573

High

1103397

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.573

High

1086321

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.549

High

1347467

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.549

High

1028886

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.541

High

1432093

ADNP
Activity-dependent neuroprotector homeobox protein

1

1

High-throughput

0.536

High

1439219

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

3

High-throughput

0.536

High

1446804

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

106692

APRIO
Alternative prion protein

2

4

High-throughput

0.533

High

1401023

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

4

Small-scale

0.527

High

1037391

H11
Histone H1.1

1

0

High-throughput

0.493

High

1406052

PHB2
Prohibitin-2

1

0

High-throughput

0.493

High

139145

KRIT1
Krev interaction trapped protein 1

1

3

Small-scale

0.479

High

164451

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

404448

GCR
Glucocorticoid receptor

1

4

High-throughput

0.479

High

463785

LYN
Tyrosine-protein kinase Lyn

1

17

High-throughput

0.479

High

559008

LYL1
Protein lyl-1

1

2

High-throughput

0.479

High

562422

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

693104

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

791753

SYUA
Alpha-synuclein

1

2

Small-scale

0.479

High

887469

CEBPD
CCAAT/enhancer-binding protein delta

1

1

Small-scale

0.479

High

1124061

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.479

High

1255668

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1379912

KISSR
KiSS-1 receptor

1

5

Small-scale

0.479

High

1381977

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.479

High

1446803

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

402689

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.458

High

580706

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

593224

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

975265

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1286920

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.458

High

1431654

GAN
Gigaxonin

1

0

High-throughput

0.458

High

255226

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

530415

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

710512

EPHA2
Ephrin type-A receptor 2

1

16

High-throughput

0.437

High

845817

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.437

High

1446802

DYH9
Dynein axonemal heavy chain 9

1

1

High-throughput

0.437

High

404921

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1119321

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High


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Last updated: 11Aug2025