HitPredict

Interactor 1: IRF8 (P23611)
Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP)
Gene: IRF8

Interactor 2: TLR11 (Q6R5P0)
Toll-like receptor 11 (Toll-like receptor 12)
Gene: TLR11

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	19801549
Identification Methods	electrophoretic mobility supershift assay, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009617 - response to bacterium
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 424 Mm			1 926
+	Mm
		618977 IRF8_MOUSE (1-424): 0: 586: 100.00		TLR13_MOUSE (46-926): 2.85e-109: 362: 22.47
+	Mm
		619087 IRF8_MOUSE (1-424): 0: 586: 100.00		TLR4_MOUSE (66-918): 2.43e-92: 312: 20.82
+	Mm
		1145136 IRF4_MOUSE (6-384): 2.1e-156: 451: 43.24		TLR4_MOUSE (66-918): 2.43e-92: 312: 20.82
+	Hs
		179932 IRF8_HUMAN (1-424): 0: 574: 89.67		TLR3_HUMAN (1-577): 9.12e-39: 158: 17.82
+	Hs
		120146 IRF8_HUMAN (1-424): 0: 574: 89.67		TLR4_HUMAN (49-562): 1.22e-32: 138: 16.30
+	Mm
		619075 IRF8_MOUSE (1-424): 0: 586: 100.00		TLR9_MOUSE (10-365): 2.14e-20: 99.4: 15.63
+	Hs
		120153 IRF4_HUMAN (6-384): 4.64e-155: 447: 42.27		TLR4_HUMAN (49-562): 1.22e-32: 138: 16.30
+	Hs
		237495 IRF3_HUMAN (9-388): 6.95e-146: 423: 28.72		TLR2_HUMAN (60-557): 3.55e-16: 85.2: 20.67
+	Hs
		179923 IRF1_HUMAN (9-266): 9.31e-86: 266: 27.27		TLR3_HUMAN (1-577): 9.12e-39: 158: 17.82
+	Mm
		547405 IRF1_MOUSE (9-263): 5.48e-75: 238: 25.57		TLR3_MOUSE (12-559): 7.57e-35: 145: 17.62
+	Hs
		179927 IRF2_HUMAN (9-167): 5.93e-59: 197: 37.50		TLR3_HUMAN (1-577): 9.12e-39: 158: 17.82
+	Mm
		621183 IRF2_MOUSE (9-167): 1.36e-58: 196: 36.25		TLR3_MOUSE (12-559): 7.57e-35: 145: 17.62
+	Mm
		547407 IRF1_MOUSE (9-263): 5.48e-75: 238: 25.57		TLR9_MOUSE (10-365): 2.14e-20: 99.4: 15.63
+	Mm
		621184 IRF2_MOUSE (9-167): 1.36e-58: 196: 36.25		TLR9_MOUSE (10-365): 2.14e-20: 99.4: 15.63