Protein: CBLB
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)

Gene: CBLB
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q13191

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0002669 - positive regulation of T cell anergy
GO:0002870 - T cell anergy
GO:0005509 - calcium ion binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

507911

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

7

9

Small-scale

0.965

High

982176

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

11

Small-scale

0.870

High

1097932

CBLB
E3 ubiquitin-protein ligase CBL-B

2

14

Small-scale

0.778

High

987605

GRB2
Growth factor receptor-bound protein 2

18

20

Small-scale

0.767

High

1097952

SH3K1
SH3 domain-containing kinase-binding protein 1

13

20

Small-scale

0.764

High

363215

EGFR
Epidermal growth factor receptor

16

20

Small-scale

0.759

High

222074

NCK2
Cytoplasmic protein NCK2

8

20

High-throughput

0.755

High

651309

CBL
E3 ubiquitin-protein ligase CBL

2

12

Small-scale

0.754

High

1097937

NEDD8
Ubiquitin-like protein NEDD8

1

2

Small-scale

0.724

High

699731

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

5

8

Small-scale

0.706

High

855608

CRK
Adapter molecule crk

4

20

High-throughput

0.696

High

440531

FYN
Tyrosine-protein kinase Fyn

4

20

High-throughput

0.683

High

943760

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

3

20

Small-scale

0.672

High

855863

CRKL
Crk-like protein

3

20

Small-scale

0.660

High

1097956

GORS2
Golgi reassembly-stacking protein 2

5

2

High-throughput

0.659

High

1097965

CD2AP
CD2-associated protein

2

20

Small-scale

0.654

High

995952

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

14

High-throughput

0.647

High

584532

VAV
Proto-oncogene vav

2

20

Small-scale

0.639

High

1097949

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

4

20

Small-scale

0.637

High

849065

ZAP70
Tyrosine-protein kinase ZAP-70

3

20

Small-scale

0.631

High

1097941

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

High-throughput

0.621

High

241569

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.618

High

710217

EPHA2
Ephrin type-A receptor 2

1

19

High-throughput

0.618

High

1090619

TRAF2
TNF receptor-associated factor 2

1

12

Small-scale

0.618

High

320238

SRBS2
Sorbin and SH3 domain-containing protein 2

2

20

High-throughput

0.606

High

463078

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.606

High

1097933

PTK6
Protein-tyrosine kinase 6

2

20

High-throughput

0.606

High

1097960

VAV3
Guanine nucleotide exchange factor VAV3

2

20

High-throughput

0.606

High

1097940

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

6

High-throughput

0.602

High

1097939

DDR2
Discoidin domain-containing receptor 2

2

20

Small-scale

0.601

High

1097934

ARHG7
Rho guanine nucleotide exchange factor 7

2

20

Small-scale

0.596

High

849158

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.595

High

1097959

DP13A
DCC-interacting protein 13-alpha

2

6

High-throughput

0.594

High

772493

IRS1
Insulin receptor substrate 1

2

10

Small-scale

0.584

High

1050981

FAK1
Focal adhesion kinase 1

2

20

Small-scale

0.584

High

1053655

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

11

Small-scale

0.584

High

1097954

MYD88
Myeloid differentiation primary response protein MyD88

2

2

Small-scale

0.584

High

292832

GRAP2
GRB2-related adapter protein 2

2

20

High-throughput

0.576

High

300145

GLRX3
Glutaredoxin-3

1

2

High-throughput

0.573

High

861591

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

Small-scale

0.561

High

1097948

SP7
Transcription factor Sp7

1

10

Small-scale

0.561

High

593984

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.552

High

250243

VINEX
Vinexin

1

20

High-throughput

0.541

High

938095

ANM2
Protein arginine N-methyltransferase 2

1

2

High-throughput

0.541

High

920436

DAPK1
Death-associated protein kinase 1

1

2

High-throughput

0.536

High

1097963

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

7

High-throughput

0.536

High

189153

IPO8
Importin-8

1

2

High-throughput

0.536

High

1097955

CAR11
Caspase recruitment domain-containing protein 11

1

12

Small-scale

0.534

High

1097961

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

10

Small-scale

0.534

High

1097938

CRY1
Cryptochrome-1

1

0

High-throughput

0.518

High

193012

CFLAR
CASP8 and FADD-like apoptosis regulator

1

1

Small-scale

0.515

High

687233

HMGB2
High mobility group protein B2

1

13

High-throughput

0.515

High

1097958

ITSN2
Intersectin-2

1

20

High-throughput

0.515

High

767192

MERL
Merlin

1

8

High-throughput

0.515

High

775055

FUS
RNA-binding protein FUS

1

8

High-throughput

0.515

High

1025089

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.515

High

1031894

NC2B
Protein Dr1

1

1

High-throughput

0.515

High

1095976

TADBP
TAR DNA-binding protein 43

1

7

High-throughput

0.515

High

1097966

TF3C3
General transcription factor 3C polypeptide 3

1

4

High-throughput

0.515

High

1097962

RNF11
RING finger protein 11

1

1

High-throughput

0.508

High

227537

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.506

High

965652

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

5

Small-scale

0.501

High

1097947

ABI1
Abl interactor 1

1

20

Small-scale

0.501

High

274556

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.493

High

361239

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

212723

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

10

Small-scale

0.481

High

913646

VAV2
Guanine nucleotide exchange factor VAV2

1

20

Small-scale

0.481

High

1097944

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

High-throughput

0.481

High

1097951

OSTF1
Osteoclast-stimulating factor 1

1

20

High-throughput

0.481

High

129042

MEN1
Menin

1

4

High-throughput

0.479

High

136382

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

Small-scale

0.479

High

163293

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

9

Small-scale

0.479

High

207920

ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

1

8

Small-scale

0.479

High

221349

SPY1
Protein sprouty homolog 1

1

7

Small-scale

0.479

High

272133

OBSL1
Obscurin-like protein 1

1

5

High-throughput

0.479

High

275892

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

4

Small-scale

0.479

High

362274

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.479

High

411855

NTRK1
High affinity nerve growth factor receptor

1

19

High-throughput

0.479

High

413749

P53
Cellular tumor antigen p53

1

8

Small-scale

0.479

High

440057

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.479

High

484123

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.479

High

532076

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.479

High

557275

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.479

High

599286

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

2

Small-scale

0.479

High

628356

CD33
Myeloid cell surface antigen CD33

1

4

Small-scale

0.479

High

648499

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

711337

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.479

High

838357

STA5A
Signal transducer and activator of transcription 5A

1

3

Small-scale

0.479

High

842647

WASP
Actin nucleation-promoting factor WAS

1

7

Small-scale

0.479

High

879039

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

18

Small-scale

0.479

High

942595

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

High-throughput

0.479

High

948811

CD81
CD81 antigen

1

2

Small-scale

0.479

High

1054103

BTK
Tyrosine-protein kinase BTK

1

20

Small-scale

0.479

High

1094886

TRAF3
TNF receptor-associated factor 3

1

13

Small-scale

0.479

High

1097935

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.479

High

1097936

ITSN1
Intersectin-1

1

20

Small-scale

0.479

High

1097945

TCAM1
TIR domain-containing adapter molecule 1

1

1

Small-scale

0.479

High

1097946

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

7

Small-scale

0.479

High

1097953

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

2

Small-scale

0.479

High

1097957

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1097964

TRAF6
TNF receptor-associated factor 6

1

13

Small-scale

0.479

High

1097950

TANK
TRAF family member-associated NF-kappa-B activator

1

0

Small-scale

0.458

High

72385

A9UF07
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.445

High

193566

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

5

Small-scale

0.445

High

279153

ULK1
Serine/threonine-protein kinase ULK1

1

1

Small-scale

0.445

High

1097943

DBX2
Homeobox protein DBX2

1

8

High-throughput

0.437

High

171067

VP26C
Vacuolar protein sorting-associated protein 26C

2

0

High-throughput

0.316

High

1097942

Q6NUL7
Serine palmitoyltransferase 1

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025