HitPredict

Interactor 1: GATA2 (P23769)
Endothelial transcription factor GATA-2 (GATA-binding protein 2)
Gene: GATA2

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0010629 - negative regulation of gene expression
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 197
+	Hs
		620331 GATA2_HUMAN (1-480): 0: 529: 100.00		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		620329 GATA2_HUMAN (1-480): 0: 529: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		620330 GATA2_HUMAN (1-480): 0: 529: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		620481 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		620482 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		620487 GATA3_HUMAN (1-480): 3.1e-135: 399: 61.24		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		554431 GATA1_HUMAN (186-480): 8.32e-69: 227: 43.35		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		554432 GATA1_HUMAN (186-480): 8.32e-69: 227: 43.35		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980900 TRPS1_HUMAN (153-447): 1.96e-56: 204: 23.76		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		554438 GATA1_HUMAN (186-480): 8.32e-69: 227: 43.35		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00