HitPredict

Interactor 1: COT2 (P24468)
COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2)
Gene: NR2F2

Interactor 2: AKT2 (P31751)
RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta)
Gene: AKT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 414 Hs			1 481
+	Hs
		622764 COT2_HUMAN (1-414): 8.99e-140: 407: 100.00		AKT1_HUMAN (1-478): 0: 564: 81.63
+	Hs
		369067 ESR1_HUMAN (1-400): 5.27e-102: 316: 23.01		AKT2_HUMAN (1-481): 0: 589: 100.00
+	Hs
		487911 RARA_HUMAN (1-408): 3.98e-106: 322: 26.93		AKT1_HUMAN (1-478): 0: 564: 81.63
+	Hs
		369066 ESR1_HUMAN (1-400): 5.27e-102: 316: 23.01		AKT1_HUMAN (1-478): 0: 564: 81.63
+	Hs
		611379 NR4A1_HUMAN (5-406): 6.17e-96: 300: 28.81		AKT1_HUMAN (1-478): 0: 564: 81.63
+	Hs
		568575 HNF4A_HUMAN (57-407): 8.83e-112: 337: 34.19		KAPCA_HUMAN (141-447): 2.12e-144: 419: 41.69
+	Hs
		368941 ESR1_HUMAN (1-400): 5.27e-102: 316: 23.01		KAPCA_HUMAN (141-447): 2.12e-144: 419: 41.69
+	Hs
		369662 ESR1_HUMAN (1-400): 5.27e-102: 316: 23.01		KS6A1_HUMAN (55-456): 2.33e-109: 342: 23.13
+	Hs
		369218 ESR1_HUMAN (1-400): 5.27e-102: 316: 23.01		KS6A3_HUMAN (55-452): 8.73e-107: 335: 23.36
+	Hs
		369461 ESR1_HUMAN (1-400): 5.27e-102: 316: 23.01		KPCZ_HUMAN (149-475): 9.44e-101: 315: 46.43
+	Hs
		566337 NR1H2_HUMAN (1-399): 1.25e-96: 298: 24.84		KPCA_HUMAN (146-475): 2.81e-103: 324: 47.43
+	Hs
		823917 NR2C2_HUMAN (68-196): 7.59e-34: 134: 50.00		KPCT_HUMAN (85-481): 9.91e-147: 437: 38.19
+	Hs
		408577 NR2C2_HUMAN (68-196): 7.59e-34: 134: 50.00		KPCB_HUMAN (72-478): 5.56e-147: 436: 40.63
+	Hs
		823729 NR2C2_HUMAN (68-196): 7.59e-34: 134: 50.00		KS6A3_HUMAN (55-452): 8.73e-107: 335: 23.36